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    Regulación génica y morfogénesis

    Mecanismos moleculares y celulares que regulan la morphogenesis y homeostasis epitelial

    Dra Maria Dolores (Lola) Martín Bermudo
    Investigador/a Principal

    Resumen
    Ultimas cinco publicaciones relevantes
    Miembros del laboratorio y Colaboradores

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    Ultimas cinco publicaciones relevantes

    1. Santa-Cruz Mateos, C., Valencia-Expósito, A., Palacios, I.M. and Maria D. Martin-Bermudo (2020) Integrins regulate epithelia cell shape by controlling the architecture and mechanical properties of basal actomyosin networks. PLoS Genetics, 16 (6). https://doi.org/10.1371/journal.pgen.1008717.

    2. Soler Beatty, J., Molnar, C., Luque, C.M., de Celis J.F. and Martin-Bermudo, M.D.* (2021) EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis. PLoS Genetics. Aug. https://doi.org/10.1371/journal.pgen.1009738

    3. Hernández-del-Valle, M., Valencia-Expósito, A., López-Izquierdo, A., Casanova-Ferrer, P., Tarazona, P., Martín-Bermudo, M. D., and Míguez Gómez, D. (2022) A coarse-grained approach to model the dynamics of the actomyosin cortex. BMCB https://doi.org/10.1186/s12915-022-01279-2

    4. Klubmann-Fricke, B.J., Martín-Bermudo, M.D.* and Llimargas, M.*. (2022) The Basement Membrane controls size and integrity of the Drosophila tracheal tubes. Cell Reports, 39. https://doi.org/10.1016/j.celrep.2022.110734

    5. Valencia-Expósito, A., Gómez-Lamarca, M.J., Widmann, T. and Martín-Bermudo, M.D. (2022) Integrins cooperate with the EGFR/Ras pathway to promote epithelia survival and architecture in development and oncogenesis. Front. Cell Dev Biol., 13 June 2022. https://doi.org/10.3389/fcell.2022.892691

    6. Rincón-Ortega, L., Valencia-Expósito, A., Kabanova, A., González-Reyes, A. * and Martín-Bermudo, M.D.* (2023) Integrins control epithelial stem cell proliferation in the Drosophila ovary by modulating the Notch pathway. Front. Cell Dev Biol. https://doi.org/10.3389/fcell.2023.1114458

    7. Molina López, E., Kabanova, A., Winkel, A., Franze, K., Palacios I.M. and Martín-Bermudo, M.D. (2023) Constriction forces imposed by basement membranes regulate developmental cell migration. PLoS Biology. https://doi.org/10.1371/journal.pbio.3002172

    8. Martínez-Abarca Millán and Martín-Bermudo, M.D. (2023) Integrins act as suppressors of Ras-mediated oncogenesis in Drosophila models. Cancers, https://doi.org/10.3390/cancers15225432.

    9. Valencia-Expósito, A., Khalilgharibi, N., Martínez-Abarca Millán, A, Mao, Y. and Martín-Bermudo, M.D. (2025) Unravelling principles initiating epithelial basal folding: cell-ECM lessening followed by an increase in basolateral contractility. The EMBO J., https://doi.org/10.1038/s44318-025-00384-6.
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    Outreach:
    • Palacios, I., Vicente-Crespo, M. and Martin-Bermudo, M.D. (2020) The humble fruit fly is helping the African science community to thrive. Nature Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-020-00283-0.

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    CABD - Centro Andaluz de Biología del Desarrollo

    Universidad Pablo de Olavide
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