Cell biology and Biotechnology

Metabolism, antioxidant systems and aging

Dr Guillermo López Lluch
Researcher associated to Dr Carlos Santos Ocaña

Relevant publications
Lab members & Collaborators

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Relevant publications

1: Sumbalová Z, Kucharská J, Rausová Z, Palacka P, Kovalčíková E, Takácsová T, Mojto V, Navas P, Lopéz-Lluch G, Gvozdjáková A. Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy. Front Mol Biosci. 2022 Oct 21;9:1016352.

2: Gvozdjáková A, Sumbalová Z, Kucharská J, Rausová Z, Kovalčíková E, Takácsová T, Navas P, López-Lluch G, Mojto V, Palacka P. Mountain spa rehabilitation improved health of patients with post-COVID-19 syndrome: pilot study. Environ Sci Pollut Res Int. 2022 Sep 23:1–12.

3: Hernández-Camacho JD, Fernández-Ayala DJM, Vicente-García C, Navas-Enamorado I, López-Lluch G, Oliva C, Artuch R, Garcia-Villoria J, Ribes A, de Cabo R, Carvajal JJ, Navas P. Calorie Restriction Rescues Mitochondrial Dysfunction in Adck2-Deficient Skeletal Muscle. Front Physiol. 2022 Jul 14;13:898792.

4: Fernández-Portero C, Amián JG, de la Bella R, López-Lluch G, Alarcón D. Coenzyme Q10 levels associated to cognitive functioning and executive function in older adults. J Gerontol A Biol Sci Med Sci. 2022 Jul 31:glac152.

5: de la Bella-Garzón R, Fernández-Portero C, Alarcón D, Amián JG, López-Lluch G. Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly. Antioxidants (Basel). 2022 Jan 29;11(2):279.

6: Hernández-Camacho JD, García-Corzo L, Fernández-Ayala DJM, Navas P, López-Lluch G. Coenzyme Q at the Hinge of Health and Metabolic Diseases. Antioxidants (Basel). 2021 Nov 8;10(11):1785.

7: Beà A, Valero JG, Irazoki A, Lana C, López-Lluch G, Portero-Otín M, Pérez-Galán P, Inserte J, Ruiz-Meana M, Zorzano A, Llovera M, Sanchis D. Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway. FEBS J. 2022 May;289(9):2540-2561.

8: Santos-Ocaña C, Cascajo MV, Alcázar-Fabra M, Staiano C, López-Lluch G, Brea-Calvo G, Navas P. Cellular Models for Primary CoQ Deficiency Pathogenesis Study. Int J Mol Sci. 2021 Sep 22;22(19):10211.

9: Navas P, Cascajo MV, Alcázar-Fabra M, Hernández-Camacho JD, Sánchez-Cuesta A, Rodríguez ABC, Ballesteros-Simarro M, Arroyo-Luque A, Rodríguez-Aguilera JC, Fernández-Ayala DJM, Brea-Calvo G, López-Lluch G, Santos-Ocaña C. Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging. Biofactors. 2021 Jul;47(4):551-569.

10: López-Lluch G. Coenzyme Q homeostasis in aging: Response to non-genetic interventions. Free Radic Biol Med. 2021 Feb 20;164:285-302.

11: Carneros D, López-Lluch G, Bustos M. Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients. 2020 Nov 12;12(11):3472.

12: Moreno Fernández-Ayala DJ, Navas P, López-Lluch G. Age-related mitochondrial dysfunction as a key factor in COVID-19 disease. Exp Gerontol. 2020 Dec;142:111147.

13: Blasco N, Beà A, Barés G, Girón C, Navaridas R, Irazoki A, López-Lluch G, Zorzano A, Dolcet X, Llovera M, Sanchis D. Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species. Redox Biol. 2020 Oct;37:101736.

14: Sánchez-Cuesta A, Cortés-Rodríguez AB, Navas-Enamorado I, Lekue JA, Viar T, Axpe M, Navas P, López-Lluch G. High coenzyme Q10 plasma levels improve stress and damage markers in professional soccer players during competition. Int J Vitam Nutr Res. 2022 Jul;92(3-4):192-203.

15: Meza-Torres C, Hernández-Camacho JD, Cortés-Rodríguez AB, Fang L, Bui Thanh T, Rodríguez-Bies E, Navas P, López-Lluch G. Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet. Antioxidants (Basel). 2020 May 15;9(5):431.

16: López-Lluch G. The Important Role of CoQ10 in Aging. Antioxidants (Basel). 2019 Nov 20;8(12):570.

17: Vázquez-Fonseca L, Schaefer J, Navas-Enamorado I, Santos-Ocaña C, Hernández-Camacho JD, Guerra I, Cascajo MV, Sánchez-Cuesta A, Horvath Z, Siendones E, Jou C, Casado M, Gutiérrez P, Brea-Calvo G, López-Lluch G, Fernández-Ayala DJM, Cortés-Rodríguez AB, Rodríguez-Aguilera JC, Matté C, Ribes A, Prieto-Soler SY, Dominguez-Del-Toro E, Francesco AD, Aon MA, Bernier M, Salviati L, Artuch R, Cabo R, Jackson S, Navas P. <i>ADCK2</i> Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency. J Clin Med. 2019 Sep 2;8(9):1374.

18: Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B. PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):277-286.

19: Sañudo B, Muñoz T, Davison GW, Lopez-Lluch G, Del Pozo-Cruz J. High-Intensity Interval Training Combined With Vibration and Dietary Restriction Improves Body Composition and Blood Lipids in Obese Adults: A Randomized Trial. Dose Response. 2018 Sep 5;16(3):1559325818797015.

20: López-Lluch G, Del Pozo-Cruz J, Sánchez-Cuesta A, Cortés-Rodríguez AB, Navas P. Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition. 2019 Jan;57:133-140.

21: López-Lluch G, Hernández-Camacho JD, Fernández-Ayala DJM, Navas P. Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes? Biogerontology. 2018 Dec;19(6):461-480.

22: Gutiérrez-Casado E, Khraiwesh H, López-Domínguez JA, Montero-Guisado J, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, González-Reyes JA, Villalba JM. The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle. J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):760-769.

23: Carrasco-Garcia E, Moreno-Cugnon L, Garcia I, Borras C, Revuelta M, Izeta A, Lopez-Lluch G, de Pancorbo MM, Vergara I, Vina J, Matheu A. SOX2 expression diminishes with ageing in several tissues in mice and humans. Mech Ageing Dev. 2019 Jan;177:30-36.

24: Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P. Coenzyme Q10 Supplementation in Aging and Disease. Front Physiol. 2018 Feb 5;9:44.

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