Gene regulation and morphogenesis

Evolution of organogenetic gene networks

Full publication list

Research papers
Molina-Gil S., Sotillos S., Espinosa-Vázquez J.M., Almudí I. and C.-G. Hombría J. (2023). Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty. Nature Communications 14:5730.

Von der Decken I., Domenech Mercadé I., Srinivasan S., Sirokha D., Livshits L., Vanni S., Nef S.,  Biasson-Lauber A., Rodríguez Gutiérrez D. and Hombría C-G J. (2022). A conserved function of Human DLC3 and Drosophila Cv-c in testis development. eLife 11:e82343.

García-Ferrés M. and Sánchez-Higueras C., Espinosa Vázquez J.M. and Hombría C-G J. (2022). Specification of the endocrine primordia controlling insect moulting and metamorphosis by the JAK/STAT signalling pathway. PLoS genetics 18: e1010427.

Sánchez-Higueras C., Rastogi C., Voutev R., Bussemaker H.J., Mann R.S. and C.-G. Hombría J. (2019). In vivo Hox binding specificity revealed by systematic changes to a single cis regulatory module. Nature Communications 10:1-13.

Sotillos S., Aguilar M. and Castelli-Gair Hombría J. (2018). Functional analysis of the Drosophila RhoGAP Cv-c protein and its equivalence to the human DLC3 and DLC1 proteins. Scientific Reports 8:4601 (11pages).

Uliana J.V.C., Brancini G.T.P., Castelli-Gair Hombría J., Digiampietri L. A., Andrioli L.P. and Monesi N. (2018). Characterizing the embryonic development of B. hygida (Diptera: Sciaridae) following enzymatic treatment to permeabilize the serosal cuticle. Mechanisms of Development (2018) 154: 270-276.

Sánchez-Higueras, C. and Castelli-Gair Hombría J. (2016). Precise long-range migration results from short-range stepwise migration during ring gland organogenesis. Developmental Biology 414:45-57.

Pinto, P., Espinosa-Vazquez J.M., Rivas M.L. and Castelli-Gair Hombría J. (2015). JAK/STAT and Hox dynamic interactions in an organogenetic gene cascade. PLoSgenetics. 11:e1005412.

Sánchez-Higueras, C., Sotillos S. and Castelli-Gair Hombría J. (2014). Common origin of insect trachea and endocrine organs from a segmentally repeated precursor. Current Biology. 24 , 76-81.

Sotillos S.,  Aguilar M. and Castelli-Gair Hombría J. (2013). Forces shaping a Hox morphogenetic gene-network. Proc. Natl. Acad. Sci. USA. 110, 4303-4308.

Sotillos S.,  Krahn M., Espinosa-Vazquez J.M. and Castelli-Gair Hombría J. (2013). Src kinases mediate apical determinant Bazooka/PAR3 interaction with STAT92E and increasesignalling efficiency in Drosophila ectodermal cells. Development. 140, 1507-1516.

Rivas M.L., Espinosa-Vazquez J.M., Sambrani N., Greig S., Merabet S., Graba Y. and Castelli-Gair Hombría J. (2013). Antagonism versus cooperativity with TALE cofactors at the base of the functional diversification of Hox protein function. PLoS genetics. 9: e1003252.

Sotillos S.,  Espinosa-Vazquez J.M., Foglia F., Hu N. and Castelli-Gair Hombría J. (2010). An efficient approach to isolate STAT regulated enhancers uncovers  STAT92E fundamental role in Drosophila tracheal development. Developmental Biology. 340, 571-592.

Rivas M.L., Cobreros L., Zeidler M. P. and Castelli-Gair Hombría J. (2008). Plasticity of Drosophila STAT DNA binding shows an evolutionary basis for STAT transcription factor preferences. EMBOreports 9, 1114-1120.

Sotillos S., Díaz-Meco, M.T., Moscat, J. and Castelli-Gair Hombría J. (2008). Polarized subcellular localization of JAK/STAT components is required for efficient signalling. Current Biology. 18, 624-629

Lovegrove B., Simões S., Rivas M.L., Sotillos S., Johnson K., Knust E., Jacinto A. and Castelli-Gair Hombría J. (2006) Co-ordinated control of cell adhesion, cell polarity and cytoskeleton underlies Hox induced organogenesis in Drosophila. Current Biology 16, 2206-2216.

Simões S., Denholm B., Azevedo D., Sotillos S., Martin P., Castelli-Gair Hombría J. and Jacinto A. (2006) Compartimentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Development 133, 4257-4267.

Brown S., Zeidler M. P. and Castelli-Gair Hombría J. (2006). JAK/STAT signalling in Drosophila controls cell motility during germ cell migration. Developmental Dynamics. 235, 958-966.

Castelli-Gair Hombría J., Brown S., Häder S. and Zeidler M. P. (2005). Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand. Developmental Biology. Developmental Biology 288, 420-433.

Merabet S. Castelli-Gair Hombría J., Hu N., Pradel J. and Graba Y. (2005) Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development 132, 3093-3102.

Denholm B., Brown S., Ray R.P., Ruiz-Gómez M., Skaer H. and Castelli-Gair Hombría J. (2005). crossveinless-c is a RhoGAP required for cytoskeletal reorganisation during Drosophila embryonic morphogenesis. Development. 132, 2389-2400.

Mukherjee T., Castelli-Gair Hombría J. and Zeidler M. P. (2005) Opposing roles for Drosophila JAK/STAT signalling during cellular proliferation. Oncogene. 24, 2503-2511.

Brown S., Hu, N and Castelli-Gair Hombría J. (2003). Novel level of signalling control revealed by in situ visualisation of protein-protein interaction during development. Development 130, 3077-3084.

Brown S., Hu, N and Castelli-Gair Hombría J. (2001). Identification of the first invertebrate Interleukin JAK/STAT receptor, the Drosophila gene domeless. Current Biology. 11, 1700-1705.

Brown S. and Castelli-Gair Hombría J. (2000). Drosophila grain encodes a GATA transcription factor required for cell rearrangement during morphogenesis. Development. 127, 4867-4876.

Hu N. and Castelli-Gair J.E. (1999). Study of the posterior spiracles of Drosophila as a model to understand the genetic and cellular mechanisms controlling morphogenesis. Developmental Biology. 214, 197-210.

Castelli-Gair J.E. (1998). Implications of the spatial and temporal regulation of Hox genes on development and evolution. Int. J. Dev. Biol. 42, 437-444.

Castelli-Gair J. (1998). The lines gene of Drosophila is required for specific functions of the Abdominal-B HOX protein. Development 125, 1269-1274.

Castelli-Gair J.E. and Akam M.E. (1995). How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres. Development 121, 2973-2982.

Castelli-Gair J.E., Greig S., Micklem G. and Akam M.E. (1994). Dissecting the temporal requirements for homeotic gene function. Development 120,1983-1995.

Camprodón F. J. and Castelli-Gair J.E. (1994). Ultrabithorax protein expression in breakpoint mutants: localization of single, co-operative and redundant cis regulatory elements. Wilhelm Roux's Arch. Dev. Biol. 203, 411-421.

Castelli-Gair J.E., Capdevila M.P., Micol J.L. and García-Bellido, A. (1992). Positive and negative cis-regulatory elements in the bithoraxoid region of the Drosophila Ultrabithorax gene. Mol Gen Genet 234, 177-184.

Castelli-Gair J.E., Müller J. and Bienz M. (1992). Function of an Ultrabithorax minigene in imaginal cells. Development 114, 877-886.

Castelli-Gair J.E., Micol J.L. and García-Bellido, A. (1990). Transvection in the Drosophila Ultrabithorax gene: a Cbx1 mutant allele induces ectopic expression of a normal allele in trans. Genetics 126, 177-184.

Micol J.L., Castelli-Gair J.E. and García-Bellido, A. (1990). Genetic analysis of transvection effects involving cis-regulatory elements of the Drosophila Ultrabithorax gene. Genetics 126, 365-373.

Castelli-Gair J.E. and García-Bellido, A. (1990). Interactions of Polycomb and trithorax with cis regulatory regions of Ultrabithorax during the development of Drosophila melanogaster. EMBO J. 9, 4267-4275.
Hombría C-G J., García-Ferrés M. and Sánchez-Higueras C. (2021). Anterior Hox genes and the process of cephalization. Frontiers in Cell and Developmental Biology 9, 718175.

Hombría C-G J. and Sotillos, S. (2020). Evo-Devo: When four became two plus two. Current Biology. 30; R655-R657.

Castelli-Gair Hombría J. and González-Reyes, A. (2016). Cell signalling: combining pathways for diversification and reproducibility. Current Biology. 26; R1153-R1155.

Castelli-Gair Hombría J. and Sotillos, S. (2013). JAK-STAT pathway in Drosophila morphogenesis.  From organ selector to cell behavior regulator. JAK-STAT. 2; 3, e26089.

Castelli-Gair Hombría J. and Serras, F. (2013). Why should we care about fly tumors? The case of JAK-STAT and EGFR cooperation in oncogenesis. JAK-STAT. 2; 2, e23203.

Castelli-Gair Hombría J. (2011). Butterfly eyespot serial homology: enter the Hox genes. BMC Biol. 9,26.

Castelli-Gair Hombría J., Rivas M.L. and Sotillos, S. (2009). Genetic control of morphogenesis- Hox induced organogenesis of the posterior spiracles. Int. J. Dev. Biol. 53, 1349-1358.

Castelli-Gair Hombría J. and Sotillos, S. (2008). Disclosing JAK/STAT links to cell adhesion and cell polarity. Seminars in Cell and Developmental Biology 19, 370-378.

Castelli-Gair Hombría J. and Sotillos, S. (2006). JAK/STAT signalling: STAT cannot play with Ken and Barbie. Current Biology 16, R98-R100.

Castelli-Gair Hombría J. and Lovegrove, B. (2003). Beyond homeosis-HOX function in morphogenesis and organogenes. Differentiation 71, 461-468.

Castelli-Gair Hombría J. and Brown, S. (2002). The fertile field of Drosophila JAK/STAT signalling. Current Biology 12, R569-R575.

Akam M., Averof M., Castelli-Gair J., Dawes R., Falciani F. and Ferrier D. (1994). The evolving role of Hox genes in arthropods. Development 120 Supplement, 209-215.
Book chapters
Castelli-Gair Hombría J., Sánchez-Higueras C., Sánchez-Herrero E. (2016). Control of organogenesis by Hox genes. In : "Organogenetic gene networks" Castelli-Gair Hombría, J. and P. Bovolenta (eds.) (ISBN: 978-3-319-42765-2). Springer. Cham, Switzerland.

Castelli-Gair Hombría J., and P. Bovolenta (2016). Models for studying organogenetic gene networks in the 21st century. In : "Organogenetic gene networks" Castelli-Gair Hombría, J. and P. Bovolenta (eds.) (ISBN: 978-3-319-42765-2). Springer. Cham, Switzerland.

Castelli-Gair J.E. (1999). Homeotic genes. Vol. 2: 1161-1163. In: Encyclopedia of molecular biology. (T. E. Creighton, ed.), John Wyley and Sons, Inc. New York.

Castelli-Gair J.E. (1999). Homeotic genes. Vol. 2: 1161-1163. In: Encyclopedia of molecular biology. (T. E. Creighton, ed.), John Wyley and Sons, Inc. New York.

Castelli-Gair J.E. (1999). Ultrabithorax genes. Vol. 4: 2717-2719. In: Encyclopedia of molecular biology. (T. E. Creighton, ed.), John Wyley and Sons, Inc. New York.

Castelli-Gair J.E., Elvira R., Sánchez M.J. and Ramos, A. (1983). Zonas Verdes de Carabanchel. In: Carabanchel Puertas Abiertas. Ed. Junta Municipal de Carabanchel. Madrid, (Spain).
Edited books
Castelli-Gair Hombría J. and P. Bovolenta (eds.). Organogenetic gene networks. Genetic control of organ formation  (ISBN: 978-3-319-42765-2). Springer. Cham, Switzerland.(2016).

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