Gene regulation and morphogenesis

Establishment of cell polarity and its relationship to signaling.

Full publication list

Research papers
(1) Nueda, A., Lopez-Rodriguez, C., Rubio, M.A., Sotillos, M.S., Postigo, A., del Pozo, M.A., Vega, M.A., and Corbi, A.L. (1995). Hematopoietic cell-type-dependent regulation of leukocyte integrin functional activity: CD11b and CD11c expression inhibits LFA-1-dependent aggregation of differentiated U937 cells. Cellular immunology 164, 163-169.

(2) Rubio, M.A., Sotillos, M.S., Jochems, G., Alvarez, V., and Corbi, A.L. (1995). Monocyte activation: rapid induction of alpha 1/beta 1 (VLA-1) integrin expression by lipopolysaccharide and interferon-gamma. European journal of immunology 25, 2701-2705.

(3) Sotillos, S., Roch, F., and Campuzano, S. (1997). The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development (Cambridge, England) 124, 4769-4779.

(4) Sotillos, S., and Campuzano, S. (2000). DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc. Development (Cambridge, England) 127, 5427-5438.

(5) Sotillos, S., Diaz-Meco, M.T., Caminero, E., Moscat, J., and Campuzano, S. (2004). DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. The Journal of cell biology 166, 549-557.

(6) Sotillos, S., and De Celis, J.F. (2005). Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development. Dev Dyn 232, 738-752.

(7) Sotillos, S., and de Celis, J.F. (2006). Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mechanisms of development 123, 241-251.

(8) Simões S., Denholm, B, Azevedo D., Sotillos S., Martin P., Skaer H., Castelli-Gair Hombría J., Jacinto A. (2006) Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Development 133, 4257-4267.

(9) Lovegrove B., Simões S., Rivas M.L., Sotillos S., Johnson K., E. Knust E., Jacinto A. and Castelli-Gair Hombría J. (2006) Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila. Current Biology 16, 2206-2216. 

(10) Sotillos, S*., Díaz-Meco, M.T., Moscat, J. and Castelli-Gair Hombría J. (2008). Polarized subcellular localization of JAK/STAT components is required for efficient signalling. Current Biology 18, 624-629.

(11) Sotillos, S., Jose Manuel Espinosa-Vázquez, Filippo Foglia, Nan Hu and Castelli-Gair Hombría J. (2010). An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. Developmental Biology. 340, 571-592.

(12) Letizia, A., Sotillos, S., Campuzano, S., and Llimargas, M. (2011). Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. Journal of cell science 124, 240-251.

(13) Sotillos, S., Aguilar M., and Castelli-Gair Hombría J. (2013). Forces shaping a Hox morphogenetic gene network. PNAS 110, 4303-4308.

(14) Sol Sotillos*, Michael Krahn, Jose Manuel Espinosa and James Castelli-Gair Hombría. (2013). Src kinases mediate apical determinant Bazooka/PAR3 interaction with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. Development 140, 1507-1516.

(15) Sánchez-Higueras, C., Sotillos, S.,  and Castelli-Gair Hombría J. (2014). Common Origin of Insect Trachea and Endocrine Organs from a Segmentally Repeated Precursor. Current Biology 1, 76-81

(16) Calero-Cuenca FJ, Espinosa-Vázquez JM, Reina-Campos M, Díaz-Meco MT, Moscat J, Sotillos S.* Nuclear fallout provides a new link between aPKC and polarized cell trafficking. BMC Biol. (2016) Apr 18;14:32. doi: 10.1186/s12915-016-0253-6.

(17) FJ Calero-Cuenca, Sotillos, S.*, Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development
Small GTPases 9 (4), 352-359.

(18) Sotillos S*, Aguilar-Aragon M, Hombría JC*. Functional analysis of the Drosophila RhoGAP Cv-c protein and its equivalence to the human DLC3 and DLC1 proteins. Sci Rep. (2018) Mar 15;8(1):4601. doi: 10.1038/s41598-018-22794-9.

(19) Gómez-Gálvez P, Vicente-Munuera P, Tagua A, Forja C, Castro AM, Letrán M, Valencia-Expósito A, Grima C, Bermúdez-Gallardo M, Serrano-Pérez-Higueras Ó, Cavodeassi F, Sotillos S, Martín-Bermudo MD, Márquez A, Buceta J, Escudero LM*.  Scutoids are a geometrical solution to three-dimensional packing of epithelia. Nat Commun. (2018) Jul 27;9(1):2960. doi: 10.1038/s41467-018-05376-1.
(R1) Castelli-Gair Hombría J. and Sotillos, S. (2006). JAK/STAT signalling: STAT cannot play with Ken and Barbie. Current Biology 16, R98-R100.

(R2) Castelli-Gair Hombría J. and Sotillos, S. (2008). Disclosing JAK/STAT links to cell adhesion and cell polarity. Seminars in Cell and Developmental Biology. 19, 370-378.

(R3) Castelli-Gair Hombría J., Rivas M.L. and Sotillos, S. (2009). Genetic control of morphogenesis-Hox induced organogenesis of the posterior spiracles. Int. J. Dev. Biol. 53, 1349-1358.

(R4) Hombría JC. and Sotillos, S. (2013). JAK/STAT pathway in Drosophila morphogenesis: From organ selector to cell behavior regulator. JAK-STAT 1, e(3): e26089.

(R5) Castelli-Gair Hombría J. and Sotillos, S. (2020). Evo–Devo: When Four Became Two Plus Two. Current Biology 30, R655-R657.
Book chapters

(C1) S. Sotillos y S. Campuzano. Role of achaete-scute complex genes in the development of the adult peripherial nervous system of Drosophila melanogaster In : "Key Experiments in Practical Developmental Biology" Marí-Beffa, M. and J. Knight (eds.) pp:255-268. (ISBN: 0521833159). Cambridge University Press. New York.

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