Gene regulation and morphogenesis

Establishment of cell polarity and its relationship to signaling.

Five relevant publications

  • 1. Sol Sotillos*; Isabel von der Decken; Ivan Domenech Mercadé;…; James C-G Hombría. A conserved function of Human DLC3 and Drosophila Cv-c in testis development. eLife (2022); 11:e82343. https://doi.org/10.7554/eLife.82343.

    2. Sotillos S*, Aguilar-Aragon M, Hombría JC*. Functional analysis of the Drosophila RhoGAP Cv-c protein and its equivalence to the human DLC3 and DLC1 proteins. Sci Rep. (2018) Mar 15;8(1):4601. doi: 10.1038/s41598-018-22794-9.

    3. Calero-Cuenca FJ, Espinosa-Vázquez JM, Reina-Campos M,…, Sotillos S.* Nuclear fallout provides a new link between aPKC and polarized cell trafficking. BMC Biol. (2016) Apr 18;14:32. doi: 10.1186/s12915-016-0253-6.

    4. Sotillos S*, Krahn M, Espinosa-Vázquez JM, Hombría JC. Src kinases mediate the interaction of the apical determinant bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. Development. (2013) 140(7):1507-16.
    doi:10.1242/dev.092320

    5. Sotillos S*, Díaz-Meco MT, Moscat J, Castelli-Gair Hombría J. Polarized Subcellular Localization of JAK/STAT Components Is Required for Efficient Signaling. Current Biology. (2008). 18, pp.624-629. doi: 10.1016/j.cub.2008.03.055.

    *Corresponding author

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