Cell biology and Biotechnology

CRISPR-Cas in vivo optimizations to understand early vertebrate development and human diseases

Dr. Miguel Angel Moreno Mateos

Principal Investigator

Summary
Five relevant publications
Lab members & Collaborators

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Five relevant publications

J. Vicencio*, C. Sánchez-Bolaños* , I. Moreno-Sánchez, D. Brena , C.E. Vejnar, D. Kukhtar, M. Ruiz-López, M. Cots-Ponjoan, A. Rubio, N.R. Melero, J. Crespo-Cuadrado, C. Carolis, A.J. Pérez-Pulido , A.J. Giráldez, B.P. Kleinstiver, J. Cerón+, M. A. Moreno-Mateos+. Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes. Nature Communications 2022, May 12;13(1):2601. *Equal contribution +Corresponding Authors
L. Hernandez-Huertas, G. Kushawah, A. Diaz-Moscoso, L. Tomas-Gallardo, I. Moreno-Sanchez , G. Da Silva Pescador, A.A. Bazzini+, M. A. Moreno-Mateos+. Star Protocols, 2021 Dec 23;3(1):101058 Optimized CRISPR-RfxCas13d system for RNA targeting in zebrafish embryos. +Corresponding Authors
G. Kushawah, L. Hernandez-Huertas, J. Abugattas-Nuñez del Prado, J.R. Martinez-Morales, M.L. DeVore, H. Hassan, I. Moreno-Sanchez, L. Tomas-Gallardo, A. Diaz-Moscoso, D.E. Monges, J.R. Guelfo, W.C. Theune, E.O. Brannan , W. Wang , T.J. Corbin , A.M. Moran, A. Sánchez Alvarado, E. Málaga-Trillo, C.M. Takacs, A.A. Bazzini+, M. A. Moreno-Mateos+. CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos. Developmental Cell 2020, Aug 1:S1534-5807(20)30587-6. +Corresponding Authors.
S. H. Chan, Y. Tang, L. Miao, H. Darwich-Codore, C.E. Vejnar, J. D. Beaudoin, D. Musaev, J. P. Fernandez, María D.J. Benítez, Ariel A. Bazzini, M. A. Moreno-Mateos+, A. J. Giraldez+. Brd4 and P300 regulate zygotic genome activation through histone acetylation. Developmental Cell 2019, Jun 17;49(6):867-881.e8. +Corresponding Authors.
M. A. Moreno-Mateos+, J. P. Fernandez, R. Rouet, C. E. Vejnar; M. A. Lane, E. Mis, M. K. Khokha, J. A. Doudna, A. J. Giraldez+. CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing. Nature Communications 2017, 8 (1) 2024. +Corresponding Authors
M.A. Moreno-Mateos*, C. E. Vejnar *, J-D. Beaudoin, J. P. Fernandez, E. K. Mis, M. Khokha and A. J. Giraldez. CRISPRscan: designing highly efficient sgRNAs for CRISPR/Cas9 targeting in vivo. Nature Methods 2015, 12 (10): 982-88. *Equal contribution

All publications:
https://pubmed.ncbi.nlm.nih.gov/?term=moreno-mateos+m&sort=date&size=20

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