Cell biology and Biotechnology

CURRICULUM VITAE

Prof. Plácido Navas

Professor of Cell Biology

Centro Andaluz de Biología del Desarrollo
Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
Instituto de Salud Carlos III
Universidad Pablo de Olavide-CSIC
Sevilla, Spain
www.upo.es/CABD
 

EDUCATION

University of Sevilla        MS       1976     Biology

University of Sevilla       PhD       1978     Cell Biology

Purdue University         Postdoc           1984-86             Biochemistry
 

RESEARCH AND PROFESSIONAL EXPERIENCE

Faculty of Sciences, U. Sevilla, Asst. Professor,1976-78

Faculty of Biology, U. Sevilla, Assoc. Professor,1979-82

Dept. Cell Biology, U. Córdoba, Assoc. Professor, 1983

Purdue University, Cancer Center, Postdoctoral, 1984-86

Dept. Cell Biology, U. Córdoba, Assoc. Professor, 1987

Dept. Cell Biology, U. Córdoba, Professor, 1988- October 1997

CABD, U. Pablo de Olavide Sevilla. Professor, November 1997-present

PhD Award, University of Sevilla, 1979

Fullbright Fellowship, 1984-86

Co-Organizer: NATO Advanced Research Workshop, Plasma Membrane Oxidoreductase in Control of Animal and Plant Growth, Córdoba, Spain, March 21-25, 1988

Co-Director: NATO/ASCB Joint Meeting, Molecular Mechanisms of Membrane Traffic, Airlie Conference Center, Virginia, USA, May 9-13, 1992

Co-Organizer: Advanced Research Workshop, Molecular Biology and Function of Plasma Membrane Redox, Córdoba March 22-25, 1994

Director, Integrated Action Spain-Germany between Hamburg Univ. and Univ. Córdoba, 1991-1995

President Organizing Committee of the VII National Congress of the SEBC. Córdoba, september 1997.

Member of the American Society for Cell Biology

Member of the American Society of Biochemistry and Molecular Biology

Member of the International CoQ Association

Head, Dept. Cell Biology, U. Córdoba, 1987-1990

Vice-Chancellor for Research, U. Córdoba, 1990-1994

PROTOPLASMA, Editor, 1994-2000

Head, Dept. Cell Biology, U. Córdoba, 1994- October 1997

Vicepresident for Research, U. Pablo de Olavide Sevilla,November 1997-2001

Adjunct Professor, Department of Foods and Nutrition, Purdue University, Indiana, USA, 1995-2000

Member of the Advisorand Committee no. 3 (Cellular and Molecular Biology) of the National Commission for Research Evaluation, 1997-1998

Member of the Executive Committee of the International Coenzyme Q10 Association, 2002-2012

President of the International Coenzyme Q10 Association, 2013

Vice-Chancellor for Academic Organization, International University of Andalucía, 2007-present

Journal of Gerontology, Biological Sciences, Co-Deputy Editor, 2008-present

PhD Thesis directed: 21 (1987-2013)
 

PUBLICATIONS

1 Zamorano, C., J.L. López-Campos, P. Navas, G.Sánchez and L. Díaz-Flores:"Epidermic xantophores in the Lacerta lepida". Morf. Norm. Patol. A1, 309-319 (1977).

2 López-Campos,J.L., J. Aznar, J. Piñero, J.M. López-Muñoz and P. Navas: "Influence of fasting and total water restriction on cortical of rat kidneand". Morf. Norm. Patol. A2, 497-512 (1978).

3 López-Campos, J.L., J. Aznar, J.M. López-Muñoz, J. del Prado, C. Zamorano, J.R. Alemany, P. Navas and J. Piñero: "Renal effects of prolonged management with bumetanide and furosemide in guinea pig". Morf. Norm. Patol. B2, 243-259 (1978).

4 Navas, P., L. Díaz-Flores, G. Sánchez, C. Zamorano and J.L. López-Campos: "Morphology and development of a type of mixtiform gland in the skin of Rana ridibunda". Morf. Norm. Patol. A2, 91-104 (1978).

5 Navas, P., J.L. López-Campos and L. Díaz-Flores: "Ultrastructure of the cell components in the mucous glands of Bufo calamita". Morf. Norm. Patol. A3, 41-49 (1979).

6 Navas, P., L. Díaz-Flores and J.L. López-Campos: "Ultrastructural modifications of secretory granules in serous glands from Bufo calamita". Morf. Norm. Patol. A3, 15-22 (1979).

7 Navas, P., J. Hidalgo, Ch. Bueno and J.L. López-Campos: "Histochemical analysis of the lingual glands in Columba columba". Arch. Biol. (Bruxelles) 90, 437-444 (1979).

8 Navas, P., Ch. Bueno, J. Piñero, J. Aijon and J.L. López-Campos: "Histochemical analysis on salivary glands of Columba columba. Anterior mandibular gland". Morf. Norm. Patol. A4, 525-531 (1980).

9 Lara, J. T. Ortiz, P. Navas, J. Aijon and J.L. López-Campos: "The carp optic tectum. A Golgi-Colonnier study". Morf. Norm. Patol. A4, 213-223 (1980).

10 Sánchez, I., J. Piñero, J. Hidalgo, P. Navas, J. Aijon and J.L. López-Campos: "Ultraestructure of the kidney in Helix aspersa". Morf. Norm. Patol. A4, 243-255 (1980).

11 Navas, P., J.L. López-Campos and L. Díaz-Flores: "Epidermical differences on the granular stratum of Rana ridibunda and Bufo calamita". Morf. Norm. Patol. A4, 313-321 (1980).

12 Navas, P., J. Hidalgo, J. Aijon and J.L. López-Campos: "Histochemical study on the tongue of Rana ridibunda (Anuran,  Amphibian)". Folia. Histochem. Cytochem. 19, 39-46 (1981).

13 López-Muñoz, J.M., I. Martín, P. Navas, C. Zamorano and J.L. López-Campos: "Ultrastructural study of the optic nerve fibers of Sepia officinalis". Morf. Norm. Patol. A5, 139-148 (1981).

14 Aguirre, J.A., P. Navas, J. Piñero, J. Aijon and J.L. López-Campos: "Myofilaments in muscle fibre of Allolobophora chlorotica sav. (Annelida, Oligochaeta)". Morf. Norm. Patol. A5, 231-242 (1981).

15 Domínguez, E., P. Navas, J. Hidalgo, J. Aijon and J.L. López-Campos: "Mucous glands of the skin of Rana ridibunda. A histochemical and ultrastructural study". Basic Appl. Histochem. 25, 15-22 (1981).

16 Bueno, Ch., P. Navas, J.A. Aguirre, J. Aijon and J.L. López-Campos: "Skin mucous glands of Pleurodeles waltlii mich. Histochemical and ultrastructural study". Arch. Biol. (Bruxelles) 92, 67-72 (1981).

17 Bueno, Ch., P. Navas, J. Aijon and J.L. López-Campos: "Glycoconjugates in the epidermis of Pleurodeles waltlii". J. Ultrastruct. Res. 77, 354-359 (1981).

18 Moreno, J., J. Piñero, J. Hidalgo, P. Navas, J. Aijon and J.L. López-Campos: "Histochemical and ultrastructural studies on the salivary glands of Helix aspersa (Mollusca)". J. Zool. 196, 343-354 (1982).

19 López-Campos, J.L., J. Piñero, J. Lasierra, P. Navas, J. Moreno and R. Cobo: "Modificaciones de los mucopolisacáridos and alteraciones ultraestructurales en la ateromatosis experimental". Rev. Clínica Española. 165, 15-21 (1982). España. A.

20 Velasco, A., P. Navas, Ch. Bueno and J.L. López-Campos:  "Carbohanddrate cytochemistry on hypodermic lymphatic endothelium of the green lizard, Lacerta hispanica". Histochem. J. 14, 943-947 (1982).

21 Moreno, F.J., J. Hidalgo, J. Piñero, P. Navas, J. Aijon and J.L. López-Campos: "Cellular types in the digestive gland of Helix aspersa (Gastropod, Pulmonate)". Morf. Norm. Patol. A6, 153-168 (1982).

22 Sánchez, I., J. Hidalgo, P. Navas, J. Aijon and J.L. López-Campos: "Histochemical study of the kidney sac in Helix aspersa". Morf. Norm. Patol. A6, 345-351 (1982).

23 Navas, P., Ch. Bueno, J. Hidalgo, J. Aijon and J.L. López-Campos: "Secretion and secretory cycle of tegumentary serous glands in Pleuredeles waltlii Mich". Basic Appl. Histochem. 26, 7-15 (1982).

24 Calvo, P., A. Torres, P. Navas and J. Pérez-Silva: "Complex carbohydrates in the cyst wall of Histriculus similis". J. Gen. Microbiol. 129, 829-832 (1983).

25 Espuelas, G.M., P. Navas, Ch. Bueno, J. Hidalgo and J.L. López-Campos: "Glycoconjugates cytochemistry in the epidemis of Candprinus carpio L.". Arch. Biol. (Bruxelles) 95, 139-152 (1984).

26 Amores, P., J. Hidalgo, P. Navas, I. Sánchez-Aguaando and J.L. López-Campos: "Cellular types in the gill arch of the teleost Candprinus carpio (Candprinidae, pisces). A. histochemical and ultrastructural study". Basic Appl. Histochem. 28, 291-307 (1984).

27 Navas, P., J.M. Villalba and G. García-Herdugo: "Carbohydrate cytochemistry on the cell surface coat of amphibian keratinocytes during differentiation". Z. mikrosk.-anat. Forsch. 99, 447-454 (1985).

28 Navas, P., I.L. Sun, D.J. Morré and F.L. Crane: "Decrease of NADH in HeLa cells in the presence of transferrin or ferricyanide". Biochem. Biophys. Res. Commun. 135, 110-115 (1986).

29 Navas, P., N. Minnifield, I.L. Sun and D.J. Morré: "NADP phosphatase as a marker in free-flow electrophoretic separations for cisternae of the Golgi apparatus midregion". Biochim. Biophys. Acta 881, 1-9 (1986).

30 Sun, I.L., P. Navas, F.L. Crane, J.AND. Chou and H. Löw: "Transplasmalemma electron transport is changed in simian virus 40 transformed liver cells". J. Bioenerg. Biomembr. 18, 471-485 (1986).

31 Navas, P., A. Hidalgo and G. García-Herdugo: "Cytokinesis in onion roots: inhibition by vanadate and caffeine". Experientia 42, 437-439 (1986).

32 González-Reyes, J.A., P. Navas and G. García-Herdugo: "An Ultrastructural study of cell plate modifications induced by 2,6-Dichlorobenzonitrile in onion root meristems". Protoplasma 132, 172-178 (1986).

33 Minnifield, N., K.E. Creek, P. Navas and D.J. Morré: "Involvement of cis and trans Golgi apparatus elements in the intracellular sorting and targeting of acid hydrolases to lysosomes". Eur. J. Cell Biol. 42, 92-100 (1986).

34 Löw, H., I.L. Sun, P. Navas, C. Grebing, F.L. Crane and D.J  Morré: "Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system". Biochem. Biophys. Res. Commun. 139, 1117-1123 (1986).

35 Morré, D.J., P. Navas, C. Penel and F. Castillo: "Auxin - stimulated NADH oxidase (semidehydroascorbate reductase ) of soybean plasma membrane: role in acidification of cytoplasm?". Protoplasma 133, 195-197 (1986).

36 Villalba, J.M., P. Navas and G. García-Herdugo: "Lectin binding patterns in amphibian epidermis". Acta histochem. 81, 51-57 (1987).

37 Moya, L., F. Guerrero, P. Navas and G. García-Herdugo: "GNRH induces activation of Leydig-like cells in Pleurodeles waltlii. A morphometric study". Histol. Histopath. 2, 193-198 (1987).

38 Burón, M.I., G. García-Herdugo and P. Navas: "Sodium pump as defined by K+-stimulated p-nitrophenyl phosphatase shows a gradient from inner to outer surface in frog epidermis". Ephitelia 1, 75-83 (1987).

39 Navas, P., J.M. Villalba, M.I. Burón and G. García-Herdugo: "Lectins as markers for plasma membrane differentiation of amphibian keratinocytes". Biol. Cell 60, 225-234 (1987).

40 Sun, I.L., P. Navas, F.L. Crane, D.J. Morré and H. Löw: "Diferric transferrin reductase in the plasma membrane is inhibited by adriamycin". Biochem. Inter. 14, 119-127 (1987).

41 Sun, I.L., P. Navas, F.L. Crane, D.J. Morré and H. Löw: " NADH diferric transferrin reductase in liver plasma membrane". J. Biol. Chem. 262, 15915-15921 (1987).

42 Burón, M.I., P. Navas, G. García-Herdugo and D.J. Morré: "Isolation of plasma membrane from amphibian epidermis: evidence for a basal-to-apical charge and activity gradient". Eur. J. Cell Biol. 44, 176-186 (1987).

43 Burón, M.I., G. García-Herdugo and P. Navas: "Lectin inhibition and kinetics of microsomal K+-dependent p-nitrophenyl phosphatase of frog epidermis". Comp. Biochem. Physiol. 86, 241-244 (1987).

44 Morré, D.J., F.L. Crane, I.L. Sun and P. Navas: "The role of ascorbate in biomembrane energetics". Ann. N.Y. Acad. Sci. 498, 153-171. (1987).

45 Crane, F.L., H. Löw, I.L. Sun, P. Navas and D.J. Morré: "Redox control of cell growth". En: Redox functions of the eukariotic plasma membrane". Ed. J.M. Ramirez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 3-17 (1987).

46 Morré, D.J., P. Navas and F.L. Crane: "Isolation, purification, evaluation and quantitation of plasma membranes from tissues and cultured cells: methods and applications to cell-free sYstems for analysis of growth processes". En: Redox fuctions of the eukaryotic plasma membrane. Ed. J.M. Ramírez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 93-115 (1987).

47 Navas, P., I. L. Sun, F.L. Crane and D.J. Morré: "Changes in the pyridine nucleotide pools of HeLa cells in response to growth promoting agents". En: Redox functions of the eukayotic plasma membrane. Ed. J.M. Ramírez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 51-64 (1987).

48 Sun, I.L. and P. Navas: "Transplasma membrane diferric transferrin reductase: control band antitumor drugs". En: Redox functions of the eukaryotic plasma membrane. Ed. J.M. Ramírez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 67-89 (1987).

49 Sun, I.L., P. Navas, D.J. Morré and F.L. Crane: "Modification of pyridine nucleotide pools in HeLa cells grown under growth promoting factors". Ind. Acad. Sci. 96, 377-384 (1987).

50 Navas, P., D. Nowack and D.J. Morré: "Insolation of highly purified plasma membrane from hepatomas and cultured cells by two-phase partition". In: Cell-free analysis of membrane traffic. Eds. D.J. Morré, K.E. Howell, G.M.W. Cook and W.H. Evans. Alan R. Liss, New York. pp. 237-241 (1988).

51 Burón, M.I., P. Navas, G. García-Herdugo and D.J. Morré: "Plasma membranes from amphibian epidermis: subfractionation by preparative free-flow electrophoresis". In: Cell-free analysis of membrane traffic. Eds. D.J. Moré, K.E. Howell, G.M.W. Cook and W.H. Evans. Alan R. Liss, New York. pp. 69-73 (1988).

52 Hidalgo A., P. Navas and G. García-Herdugo: "Growth inhibition induced by vanadate in onion roots". Env. Exp. Bot. 28, 131-136 (1988).

53 Gacía-Herdugo, G., J.A. González-Reyes, F. Gracia-Navarro and P. Navas: "Growth kinetics of the Golgi apparatus during the cell cycle in onion root meristems". Planta 175, 305-312 (1988).

54 Navas, P., A. Estévez, M.I. Burón, J.M. Villalba and F.L. Crane: "Cell surface glycoconjugates control the activity of the NADH-ascorbate free radical reductase of rat liver  plasma membrane". Biochem. Biophys. Res. Commun. 154, 1029-1033 (1988).

55 Burón, M.I. and P. Navas: "Thyroxin specifically stimulates anuran larvae epidermal sodium pump during metamorphosis". Comp. Biochem. Physiol. 91A, 693-695 (1988).

56 Morré, D.J., D. Nowack. G. Matyas, D.A. Werderitsh and P. Navas: "The Golgi apparatus and neoplasia". En: "Biomembranes. Basic and Medical Research". Eds. Gh. Benga and J.M. Tager. Springer, New York, pp. 130-152(1988).

57 González-Reyes, J.A., F. Gracia-Navarro, G. García-Herdugo and P. Navas: "Changes of dictyosome ultrastructure during the cell cycle in onion root meristematic cells. A morphometric and stereological study". Protoplasma 146, 35-40 (1988).

58 Navas, P., I.L. Sun, D.J. Morré and F.L. Crane: "Relationship between NAD+/NADH levels and animal cell growth". En : Plasma membrane oxidoreductase in control of animal and plant growth. Eds. F.L. Crane et al. Plenum Press, New York, pp. 339-347 (1988).

59 Navas, P., A. Estévez, J.M. Villalba and M.I. Burón: "Role of cell surface on NADH-MDHA-oxidoreductase: lectin inhibition". En : Plasma membrane oxidoreductase in control of animal and plant growth. Eds. F.L. Crane et al. Plenum Press, New York, pp. 42 (1988).

60 Hidalgo, A. and P. Navas: "Ascorbate free radical involvement in elongation-related growth processes in onion roots". En : Plasma membrane oxidoreductase in control of animal and plant growth. Eds. F.L. Crane et al. Plenum Press, New York, pp. 428 (1988).

61 González-Reyes, J.A., F. Gracia-Navarro, G. García-Herdugo, A. Hidalgo and P. Navas: "Differential morphometric values induced in Golgi apparatus of higher plant cells band aldehyde and permanganate fixation". J. Elect. Microsc. Tech. 11, 1-8 (1989).

62 Villalba, J.M. and P. Navas: "Polarization of plasma membrane glycoconjugates in amphibian epidermis during metamorphosis". Hitochemistry 90, 453-458 (1989).

63 Navas, P, D.D. Nowack, and D.J. Morré : "Isolation of purified plasma membranes from cultured cells and hepatomas band two-phase partition and preparative free-flow electrophoresis". Cancer Res. 49, 2147-2156 (1989).

64 Velasco, A., J. Hidalgo, J. Pérez-Vilar, G. García-Herdugo and P. Navas: "Detection of glycosaminoglycans in the Golgi complex of chondrocytes". Eur. J. Cell Biol. 47, 241-250 (1989).

65 Burón, M.I., J.M. Villalba and P. Navas: "NADH-ascorbate free radical reductase of rat liver plasma membrane: kinetics and lectin inhibition. Epithelia 1, 295-306 (1989).

66 Hidalgo, A., J.A. González-Reyes, P. Navas and G. García-Herdugo: "Abnormal mitosis and growth inhibition in Allium cepa roots induced by propham and chloropropham". Cytobios 57, 7-14 (1989).

67 Hidalgo, A., J.A. González-Reyes and P. Navas: "Ascorbate free radical enhaces vacuolization in onion root meristems". Plant Cell Environ. 12, 455-460 (1989). Gran

68 Navas, P. and M.I. Burón: "Roles of pyridine nucleotides in the control of cell growth". In: Oxidoreduction at the Cell Membranes : Relation to growth and transport. Vol. I: Animals. Eds. F.L. Crane, D.J. Morré, H. Löw. CRC Press, Boca Raton, pp. 225-236 (1990).

69 Navas, P.: "Ascorbate free radical (semidehydro-) reductase of plant plasma membranes". In: Oxidoreduction at the cell membranes: Relation to growth and transport. Vol. II Plants. Eds. F.L. Crane, D.J. Morré, H. Löw. CRC Press, Boca Ratón, pp. 111-120 (1991).

70 Hidalgo, A., José A. González-Reyes and P. Navas.: "Protective effects of ascorbate free radical against caffeine and dichlobenil action in onion roots". Cell Biol. Int. Rep. 14, 133-141 (1990).

71 Alcaín, F.J., M.I. Burón, J.C. Rodríguez-Aguilera,J.M. Villalba and P. Navas: Ascorbate free radical stimulates the growth of a human promyelocandtic leukemia cell line". Cancer Res. 50, 5887-5891 (1990).

72 Hidalgo, A., García-Herdugo, G., González-Reyes, J. A., Morré, D.J. and Navas P.: "Ascorbate free radical stimulates onion root growth by increasing cell elongation". Bot. Gaz. 152, 282-288 (1991).

73 Alcaín F. J., Burón M. I., Villalba J. M. and Navas P.: "Ascorbate is regenerated by HL-60 cells through the transplasmalemma redox systen". Biochim. Biophys. Acta 1073, 380-385 (1991).

74 González- Quevedo, M., Alcaín F.J., González-Reyes, J.A., Burón, M.I. and Navas P.: "Growth patterns of the HL-60 human promyelocandtic cell line stimulated by ascorbate free radical". Cancer J. 4, 262-266 (1991).

75 González-Reyes, J.A., O Döring, P. Navas, G. Obst and M Böttger: "The effect of ascorbate free radical on the energy state of the plasma membrane of onion root cells: alteration of k+ efflux by ascorbate." Biochim. Biophys. Acta 1098, 177-183 (1992).

76 Brightman, A.O., Navas P., Minnifield, N. M. and Morré, D.J.: "Pyrophosphate-induced acidification of transcisternal elements of rat liver Golgi apparatus". Biochim. Biophys. Acta 1104, 188-194 (1992)..

77 Navas P., Alcaín F. J., Burón M.I., Rodríguez-Aguilera, J.C., Villalba J.M., Morré D.M. and Morré D.J.: "Growth factor-stimulated transplasma membrane electron transport in HL-60 cells". FEBS Lett. 299, 223-226 (1992).

78 Alcaín F.J., Villalba, J. M., Löw H., Crane F.L. and Navas P.: "Ceruloplasmin stimulates NADH oxidation of pig liver plasma membrane". Biochem. Biophys. Res. Commun. 186, 951-955 (1992).

79 Navarro, F., Rodríguez-Aguilera J.C., Alcaín F.J., Burón M.I., and Navas P.: "Ascorbate potentiates serum-induced S phase entry of quiescent 3T3 cells. Protoplasma 169, 85-87 (1992).

80 Navas P., Villalba J.M., Rodríguez-Aguilera, J.C., Canalejo A. and Burón M.I.: " Clathrin interaction with NADH dehydrogenases of rat liver plasma membrane". En: "Molecular mechanisms of membrane traffic". Eds. D.J. Morré, K.E. Howell, and J.J.M. Bergeron. Springer Verlag, Heidelberg, pp. 329-330 (1993).

81 Villalba J.M., Burón M.I., Roldán J.M. and Navas P.: "Plasma membrane glycoproteins during amphibian epidermal development". Protoplasma 172, 136-144 (1993).

82 Villalba J.M., Roldán J.M. and Navas P.: "Flask cells and flask-shaped glandular cells of amphibian skin specifically produce fucose-rich glycoproteins". Histochemistry 99, 363-367 (1993).

83 Villalba J. M., Canalejo A., Rodríguez-Aguilera J.C., Burón M.I., Morré D.J. and Navas P.: "NADH-AFR and ferricandanide reductase activities represent different levels of plasma membrane electron transport". J. Bioenerg. Biomembr. 25, 411-417 (1993).

84 De Cabo, R.C., J.A. González-Reyes, and Navas P.: "The onset of cell proliferation is stimulated by ascorbate free radical in onion root primordia". Biol. Cell 77, 231-233 (1993).

85 Burón; M.I., Rodríguez-Aguilera, J.C., Alcaín, F.J. and Navas P.: "Transplasma membrane redox sandstem in HL-60 cells is modulated during TPA-induced differentation". Biochem. Biophys. Res. Commun. 192, 439-445 (1993).

86 Villalba, J.M., Canalejo, A., Burón, M.I., Córdoba, F., Navas, P.: "Thiol groups are involved in NADH-ascorbate free radical reductase activity of rat liver plasma membrane". Biochem. Biophys. Res. Commun. 192, 707-713 (1993).

87 Burón M.I., Rodríguez-Aguilera, J.C., González-Reyes, J.A., Villalba J.M., Alcaín, F.J., and Navas P.: "A quantitative ultrastructural and cytochemical study of TPA-.induced diffetentiation in HL-60 cells". Leuk. Res. 17, 863-872 (1993).

88 Navas, P. "Tráfico and bioenergética de membranas. Introducción". En: "Progresos en Biología Celular". Eds. Becerra,J., Perez-Fígares,J.M. and Fernandez-Llebrez, P. Universidad de Málaga, pp. 169-170 (1993).

89 Navas, P. "Bioenergética del aparato de Golgi del hepatocito de rata". En: "Progresos en Biología Celular". Eds. Becerra,J., Perez-Fígares,J.M. and Fernandez-Llebrez, P. Universidad de Málaga, pp. 183-186 (1993).

90 Rodríguez-Aguilera, J. C., Navarrro, F., Arroyo, A., Villalba,J.M. and Navas,P. "Transplasma membrane redox system of HL-60 cells is controlled by cAMP". J. Biol. Chem. 268, 26346-26349 (1993).

91 González-Reyes, J.A., A. Hidalgo, J.A. Caler, R. Palos and Navas P.: "Nutrient uptake changes in ascorbate free radical-stimulated onion roots". Plant Physiol. 104, 271-276 (1994).

92 Navas, P., Villalba, J.M. and Córdoba, F. "Ascorbate functions at the plasma membrane". Biochim. Biophys. Acta 1197, 1-13 (1994).

93 Villalba, J.M., Navarro, F., Roldán, J.M., González-Reyes, J.A. and Navas, P.: "Expression of carbohydrate residues in plasma membrane glycoproteins during the differentiation of amphibian epidermal cells". Protoplasma 178, 87-96 (1994).

94 Serrano, A., Villalba, J.M., González-Reyes, J.A., Navas, P. and Córdoba, F.: "Two distinct NAD(P)H-dependent redox enzymes isolated from onion root plasma membranes". Biochem. Mol. Biol. Int. 32, 841-849 (1994).

95 Serrano, A., Córdoba, F., González-Reyes, J.A., Navas, P. and Villalba, J.M. : "Purification and characterization of two distinct NAD(P)H-dehydrogenases from onion (Allium cepa L.) root plasma membrane". Plant Physiol. 106, 87-96 (1994).

96 González-Reyes, J.A., Alcaín, F.J., Caler, J.A., Serrano, A., Córdoba, F. and Navas, P.: "Relationship between apoplastic ascorbate regeneration and the stimulation of root growth in Allium cepa L." Plant Sci. 100, 23-29 (1994).

97 Crane, F.L. and Navas, P.: "Minireviews on ascorbate in membranes. Introduction". J. Bioenerg. Biomembr. 26, 347 (1994).

98 Rodriguez-Aguilera, J.C. and Navas, P.: "Extracellular ascorbate stabilization: enzymatic or chemical process?". J. Bioenerg. Biomembr. 26, 379-384 (1994).

99 López-Lluch, G., Burón, M.I., Alcaín, F.J., Borrego, F., Quesada, J.M. and Navas, P.: "Effect of ascorbate and calcitriol on HL-60 promyelocandtic cell line proliferation and differentiation". En: Vitamin D: A pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications. Eds. Norman, A.W., Bouillon, R. and Thomasset, M. Walter de Gruandter, Berlin, pp. 455-456 (1994).

100 Lüthje, S., González-Reyes, J.A., Navas, P., Döring, O. and Böttger, M.: "Inhibition of maize (Zea maands L.) root plasma membrane-bound redox activities by coumarins". Z. Naturforsch. 49c, 447-452 (1994).

101 Morré, D.J., Navas P., Rodríguez-Aguilera, J.C., Morré D.M:, Villalba J.M. De Cabo, R. de and Lawrence, J.: "Cyclic AMP- plus ATP-dependent modulation of the NADH oxidase of porcine liver plasma membranes". Biochim. Biophys. Acta. 1224, 566-574 (1994).

102 Alcaín, F.J., Löw, H., Crane, F.L. and Navas, P.: "Iron chelators hydroxyurea and bathophenanthroline disulfonate inhibit DNA synthesis by different pathways". Biochem. Mol. Biol. Int. 34, 273-279 (1994).

103 López-Lluch, G., Burón, M.I., Alcaín, F.J., Rodríguez-Aguilera, J.C. and Navas, P.: "Plasma membrane redox system during HL-60 induced differentiation". Protoplasma 184, 163-167 (1995).

104 Navas, P. and Gómez-Díaz, C. :"Ascorbate free radical and its role in growth control". Protoplasma 184, 8-13 (1995).

105 Serrano, A., Córdoba, F., González-Reyes, J.A., Santos, C., Navas, P. and Villalba, J.M.: "NADH-specific dehydrogenase from onion root plasma membrane: purification and characterization". Protoplasma 184, 133-139 (1995).

106 Rodríguez-Aguilera, J.C., Navarro, F., Arroyo, A., Alcaín, F.J., Villalba, J.M. and Navas, P.: "Vitamin C stabilization as a consequence of the plasma membrane redox system". Protoplasma 184, 229-232 (1995).

107 González-Reyes, J.A., Alcaín, F.J., Caler, J.A., Serrano, A., Córdoba, F. and Navas, P.: "Stimulation of onion root elongation by ascorbate and ascorbate free radical in Allium cepa L." Protoplasma 184, 31-35 (1995).  

108 Villalba J.M., Navarro, F., Córdoba, F., Serrano, A., Arroyo, A., Crane, F.L. and Navas, P.: "Coenzyme Q reductase from liver plasma membrane: purification and role in transplasma membrane electron transport". Proc. Natl. Acad. Sci. USA 92, 4887-4891 (1995).

109 Morré, D.J., Brightman, A.O., Hidalgo, A., and Navas, P.: "Selective inhibition of auxin-stimulated NADH oxidase activity and elongation growth of soybean hypocotyls by thiol reagents". Plant Physiol. 107, 1285-1291 (1995).

110 Santos-Ocaña, C., Navas, P., Crane, F.L. and Córdoba, F.: "Extracellular ascorbate stabilization by the yeast Saccharomyces cerevisiae". J. Bioenerg. Biomembr. 27, 597-603 (1995).

111 Navarro, F., Villalba, J.M., Crane, F.L., MacKellar, W.C. and Navas, P.: "A phospholipid-dependent NADH-Coenzyme Q reductase from liver plasma membrane". Biochem. Biophys. Res. Commun. 212, 138-143 (1995).  

112 Córdoba, M.C., Serrano, A., Córdoba, F., González-Reyes, J.A., Navas, P., and Villalba, J.M.: "Topography of the 27 and 31 kDa electron transport proteins in the onion root plasma membrane". Biochem. Biophys. Res. Commun. 216, 1054-1059 (1995).

113 Cabo, R.C. de, González-Reyes, J.A., Córdoba, F.and Navas, P.: "Rooting hastened in onions by ascorbate and ascorbate free radical". J. Plant Growth Reg. 15, 53-56 (1996).

114 Villalba, J.M., Córdoba, F. and Navas, P.: "Ascorbate and the plasma membrane: A new view of cell growth control". En: Subcellular Biochemistry. Ascorbic acid: Biochemistry and Biomedical Cell Biology, Harris,J.R. Ed. Plenum Press, New York, vol. 25, pp. 57-81 (1996).

115 Quesada, J.M., López-Lluch, G., Burón, M.I., Alcaín, F.J., Borrego, F., Velde, J.P., Blanco, I., Bouillon, R., and Navas, P.: "Ascorbate increases the 1,25 dihydroxyvitamin D3-induced monocytic differentiation of HL-60 cells". Calcified Tissue Int. 59, 277-282 (1996)

116 Córdoba-Pedregosa, M.C., González-Reyes, J.A., Cañadillas, M.S., Navas, P. and Córdoba, F.: "Role of apoplastic and cell-wall peroxidases on the stimulation of root elongation by ascorbate". Plant Physiol. 112, 1119-1125 (1996).

117 Córdoba, F., Navas, P. and González-Reyes, J.A.: "El ácido ascórbico en las plantas: regulación del crecimiento and protección contra contaminantes ambientales". Bol. Educ. Bioq. (México) 15, 182-168 (1996).

118 Villalba, J.M., Gómez-Díaz, C., Navarro, F. and Navas, P.: "Role of transplasma membrane redox system in cell protection against oxidative stress". Trends Comp. Biochem. Physiol. 2, 65-71 (1996).

119 Morré, D.J., Rodríguez-Aguilera, J.C., Navas, P. and Morré, D.M.: "Redox modulation of the response of NADH oxidase activity of rat liver plasma membrane to cyclic AMP plus ATP ". Mol. Cell. Biochem. 173, 71-77 (1997).

120 Crane, F.L. and Navas, P.: "The diversity of coenzyme Q function". Molec. Aspects Med. 18, S1-S6 (1997).

121 Villalba, J.M., Navarro, F., Gómez-Díaz, C., Arroyo, A., Bello, R.I. and Navas, P.: "Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane". Molec. Aspects Med. 18, S7-S13 (1997).

122 Gómez-Díaz, C., Rodríguez-Aguilera, J.C., Barroso, M.P., Villalba, J.M., Navarro, F., Crane, F.L. and Navas, P.: "Antioxidant ascorbate is stabilized by NADH-coenzyme Q10 reductase in plasma membrane". J. Bioenerg. Biomembr. 269, 253-259 (1997).

123 Muñoz, E., Blázquez, M.V., Ortiz, C., Gómez-Díaz, C. and Navas, P.: "Role of ascorbate in the activation of NF-kB by tumor necrosis factor ( in T cells". Biochem. J. 325, 23-28 (1997).

124 Gómez-Díaz, C., Villalba, J.M., Pérez-Vicente, R., Crane, F.L. and Navas, P.: "Ascorbate stabilization is stimulated in ((HL-60 cells by CoQ10 increase at the plasma membrane". Biochem. Biophys. Res. Commun. 234, 78-81 (1997).

125 Barroso, M.P., Gómez-Díaz, C., Villalba, J.M., Burón, M.I., López-Lluch, G. and Navas, P.: "Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal". J. Bioenerg. Biomembr. 29, 261-269 (1997).

126 Barroso, M.P., Gómez-Díaz, C., López-Lluch, G., Malagón, M.M., Crane, F.L. and Navas, P.: "Ascorbate and (-tocopherol prevent apoptosis induced by serum removal independent of Bcl-2". Arch. Biochem. Biophys. 343, 243-248 (1997).

127 López-Lluch, G., Burón, M.I., Alcaín, F.J., Quesada, J.M. and Navas, P.: "Ascorbate increases the effect of calcitriol on leukemic cells differentiation through the cAMP pathway". En: Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone. Eds. Norman, A.W., Bouillon, R. and Thomasset, M. Walter de Gruandter, Berlin, pp. 425-427  (1997).

128 López-Lluch, G., Quesada, J.M. and Navas, P.:"Papel del sistema endocrino de la vitamina D en los procesos de diferenciación". En: 25 Hidroxivitamina D and Osteoporosis". Ed. Quesada, J.M. Edika Med, SL, Barcelona, pp. 168-178  (1998).

129 Macho, A., Blázquez, M.-Valle, Navas, P. and Muñoz, E.: "Induction of apoptosis band vanilloid compounds is independent of JUN kinase and AP-1". Cell Growth Diff. 9, 277-286 (1998)

130 López-Lluch, G., Burón, M.I., Alcaín, F.J., Quesada, J.M. and Navas, P.:"Redox regulation of 1(,25-dihidroxyvitamin D3-induced differentiation of HL-60 cells by ascorbate".Biochem. J. 331, 21-27 (1998).

131 Santos-Ocaña, C., Córdoba, F., Crane, F.L., Clarke, C.F. and Navas, P.: "Role of coenzyme Q6 in the extracellular ascorbate stabilization at the plasma membrane of Saccharomyces cerevisiae". J. Biol. Chem. 273, 8099-8105 (1998)

132 Kagan, V.E., Arroyo, A., Tyurin, V.A., Tyurina, Y.Y., Villalba, J.M. and Navas, P.: "Plasma membrane NADH-coenzyme Qo reductase generates semiquinone radicals and recycles vitamin E homologue in a superoxide-dependent reaction". FEBS Lett. 428, 43-46 (1998).

133 Villalba, J.M., Navas, P. and Crane, F.L.: "Antioxidative role of ubiquinone in animal plasma membranes". In: Plasma membrane redox systems and their role in biological stress and disease. Eds. Asard, H., Berczi, A., Caubergs, R. Kluwer, Berlin. pp. 247-265 (1998).

134 González-Reyes, J.A. and Navas, P.: "Involvement of plasma membrane redox systems in growth control of animal and plant cells". En: Plasma membrane redox systems and their role in biological stress and disease. Eds. Asard, H., Berczi, A., Caubergs, R. Kluwer, Berlin. pp. 193-213 (1998).

135 Navarro, F., Navas, P., Burgess, J.R., Bello, R.I., Cabo, R. de, and Villalba, J.M. : "Vitamin E and selenium deficiency induces the expression of plasma membrane antioxidants". FASEB J. 12, 1665-1673 (1998)

136 Santos-Ocaña, C., Villalba, J.M., Córdoba, F., Padilla, S., Crane, F.L., Clarke, C.F. and Navas, P.: "Genetic evidence for coenzyme Q requirement in plasma membrane electron transport". J. Bioenerg. Biomembr. 30, 465-475 (1998)

137 Córdoba-Pedregosa, M.C., González-Reyes, J.A., Serrano, A., Villalba, J.M., Navas, P. and Córdoba, F.: "Plasmalemma-associated malate dehydrogenase activity in onion root cells". Protoplasma 205, 29-36 (1998).  

138 Arroyo, A., Navarro, F., Navas, P. and Villalba, J.M.: "Ubiquinol regeneration by plasma membrane ubiquinone reductase". Protoplasma 205, 107-113. (1998).

139 Macho, A., Calzado, M.A., Gómez-Diaz, C., Gajate, C., Mollinedo, F., Navas, P. and Muñoz, E.: "Selective induction  of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium". Cell Death Diff. 6, 155-165 (1999)

140 López-Lluch, G., Barroso, M.P., Martín, S., Fernández-Aandala, D.M., Gómez-Díaz, C., Villalba, J.M. and Navas, P.: "Role of plasma membrane coenzyme Q on the regulation of apoptosis". BioFactors 9, 171-177 (1999)

141 Navarro, F., Arroyo, A., Martín, S.F., Bello, R.I., Cabo, R. De, Burgess, J.R., Navas, P. and Villalba, J.M.:"Protective role of ubiquinone against oxidative stress caused by vitamin E and selenium deficiency". BioFactors 9, 163-170 (1999).

142 Siendones, E., González-Reyes, J.A., Santos-Ocaña, C., Navas, P. and Córdoba, F.: Biosynthesis of ascorbic acid in kidney bean. L-Galactono-(-lactone dehydrogenase is an intrinsic protein located at the mitochondrial inner membrane". Plant Physiol. 120, 907-912 (1999).  

143 Rodríguez-Aguilera, J.C., López-Lluch, G., Santos-Ocaña, C., Villalba, J.M., Gómez-Díaz, C. and Navas, P.: "Plasma membrane redox system protect cells against oxidative stress". Redox Report 5, 2-4 (2000).

144. Villalba, J.M., López-Lluch, G., Santos-Ocaña, C., Rodríguez-Aguilera, J.C., and Navas, P.: "Extramitochondrial functions of coenzyme Q". En: Coenzyme Q: Molecular Mechanisms in Health and Disease. V.E. Kagan and P.J. Quinn Eds. Pp. 83-98. CRC Press, Boca Ratón (2000).

145. Villalba, J.M. and Navas, P. "Plasma membrane redox system in the control of stress-induced apoptosis". Antiox. Redox Signal. 2, 213-230 (2000).

146. Arroyo, A., Kagan, V.E., Tyurin, V.A., Burgess, J.R., Cabo, R, de, Navas, P. and Villalba, J.M.: "NADH and NADPH-dependent reduction of coenzyme Q at the plasma membrane". Antiox. Redox Signal. 2, 251-262 (2000).  

147. Fernández-Ayala, D.J.M., Martín, S.F., Barroso, M.P., Gómez-Díaz, C., Villalba, J.M., Rodríguez-Aguilera, J.C., López-Lluch, G., and Navas, P.:"Coenzyme Q protects cells against serum withdrawal-induced apoptosis by inhibition of ceramide release and caspase-3 activation". Antiox. Redox Signal. 2, 263-275 (2000).

148. Arroyo, A., Navarro, F., Gómez-Díaz, C., Crane, F.L., Alcaín, F.J., Navas, P., and Villalba, J.M.: "Interactions between ascorbyl free radical and coenzyme Q at the plasma membrane". J. Bioenerg. Biomembr. 30, 465-475 (2000).

149. Gómez-Díaz, C., Barroso, M.P. and Navas, P.: "Plasma membrane CoQ and growth control". Protoplasma 214, 19-23 (2000).

150. Villalba J.M., Arroyo A., Navarro F., Rodríguez-Aguilera, J.C. and Navas, P. (2001) Insights in cellular protection against oxidative stress: The necessity for extramitochondrial coenzyme Q. In Mitochondrial Ubiquinone (Coenzyme Q10): Biochemical, Functional, Medical, and Therapeutic Aspects in Human Health and Diseases. Vol 2. M. Ebadi, J. Marwah, J. and R.K. Chopra, eds. (Prominent Press, Scottsdale, AZ) pp. 89-120.

151. López-Lluch, G., Blazquez, M-V., Pérez-Vicente, R., Macho, A., Burón, M.I. Alcaín, F.J. Muñoz, E. and Navas, P.: "Cellular redox state and AP-1 are involved in ascorbate effect on calcitriol-induced differentiation". Protoplasma 217, 129-136 (2001).

152. Martín, S.F., Navarro, F., Forthoffer, N., Navas, P. and Villalba, J.M.:"Neutral Magnesium-dependent sphingomyelinase from liver plasma membrane: Purificación and inhibition by ubiquinol". J. Bioenerg. Biomembr. 33, 143-153 (2001).

153. Navas, P., Fernández-Ayala. D.M., Martín, S.F., López-Lluch, G., de Cabo, R., Rodríguez-Aguilera, J.C. and Villalba, J.M.: "Biochemical Mechanisms of Plasma Membrane Coenzyme Q-dependent Cell Survival". Free Rad. Res. 36, 369-374 (2002).

154. Santos Ocaña, C., Do, T.Q., Padilla, S., Navas, P. and Clarke, C.F.: "Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants". J. Biol. Chem. 277, 10973-10981 (2002).

155. Forthoffer, N., Gómez-Díaz, C., Bello, R.I., Burón, M.I., Martín, S.F., Rodríguez-Aguilera, J.C., Navas, P. and Villalba, J.M.: "A novel plasma membrane quinone reductase and NAD(P)H:quinone oxidoreductase 1 are upregulated by serum withdrawal in human promyelocytic HL-60 cells". J. Bioenerg. Biomembr. 34, 209-219 (2002).

156. Martín, S.F., Gómez-Díaz, C., Navas, P. and Villalba, J.M.: "Ubiquinol inhibition of neutral sphingomyelinase in liver plasma membrane: specific inhibition of the Mg2+-dependent enzyme and role of isoprenoid chain". Bioichem. Biophys. Res. Commun. 297, 581-586 (2002).

157. Martín, S.F., Gómez-Díaz, C., Bello, R.I., Navas, P. and Villalba, J.M.: "Inhibition of Mg2+-dependent sphingomyelinase by ubiquinol-mediated plasma membrane electrón transport". Protoplasma 221, 109-116 (2003).

158. Gómez-Díaz, C., Burón, M.I., Alcaín, F.J., González-Ojeda, R., González-Reyes, J.A., Bello, R.I., Herman, M.D., Navas, P. and Villalba, J.M.:" Effect of dietary coenzyme Q and fatty acids on the antioxidant status of rat tisúes". Protoplasma 221, 11-17 (2003).

159. Asencio, C., Rodríguez-Aguilera, J.C., Ruiz-Ferrer, M., Vela, J. and Navas, P.:"Silencing of ubiquinone genes extends life span in Caenorhabditis elegans". FASEB J. 17, 1135-1137 (10.1096/fj.02-1022fje) (2003).

160. Bello, R.I., Alcaín, F.J., Gómez-Díaz, C., López-Lluch, G., Navas, P. and Villalba, J.M. "Hydrogen peroxide and cell density-regulated expresión of cytochrome b5 reductase in HeLa cells". J. Bioenerg. Biomembr. 35, 169-179 (2003).

161. Sánchez-Alcázar, J.A., Schneider, E., Hernández, I., Siles-Rivas, E., De la Torre, P., Borstein, B., Brea, G., Arenas, J., Garesse, R., Solís-Herruza, J.A., Knox, A. and Navas, P.: "Reactive oxigen species mediate the down-regulation of ATPase subunit a by Tumor Necrosis Factor-( in L929 cells". Biochem. J. 370, 609-619 (2003).

162. Navas, P. and Villalba, J. M.:" Regulation of ceramide signaling by plasma membrane Coenzyme Q reductases". Meth. Enzymol. 378, 200-206 (2003)

163. Arroyo, A., Rodríguez-Aguilera, J.C., Santos Ocaña, C., Villalba, J. M. and Navas, P.: "Stabilization of extracellular ascorbate mediated by coenzyme Q transmembrane electrón transport". Meth. Enzymol. 378, 207-217 (2003) USA. R.

164. Bello, R.I., Gómez-Díaz, C., Navas, P. and Villalba, J.M. "NAD(P)H:quinone oxidoreductase 1 expression, hydrogen peroxide levels and growth phase in HeLa cells". Meth. Enzymol. 382, 234-243 (2003).

165. Sánchez-Alcázar, J.A., Bradbury, D.A., Brea, G., Navas, P. and Knox, A.:"Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression". Apoptosis 8, 639-647 (2003).

166. Rodríguez-Aguilera, J.C., Asencio, C., Ruiz-Ferrer, M., Vela, J. and Navas, P.:" Caenorhabditis elegans ubiquinone biosynthesis genes". Biofactors 18, 237-244 (2003).

167. Gómez-Díaz, C., Bello, R.I., López-Lluch, G., Forthoffer, N., Navas, P.  and Villalba, J.M. "Antioxidant response induced by serum withdrawal protects HL-60 cells against inhibition of NAD(P)H:quinone oxidoreductase 1". Biofactors 18, 219-228 (2003).

168. Bello, R.I., Gómez-Díaz, Navas, P. and Villalba, J.M. NAD(P)H:quinone oxidoreductase 1 expression, hydrogen peroxide levels and growth phase in HeLa cells Meth. Enzymol.  382, 234     243 (2004).

169. Navas, P. and Villalba, J.M. Regulación of ceramide signaling by plasma membrane Coenzyme Q reductases. Meth. Enzymol.  378, 200- 206 (2004).

170. Arroyo, A., Rodríguez-Aguilera, J.C., Santos Ocaña, C., Villalba, J. M. and Navas, P. Stabilization of extracellular ascorbate mediated by coenzyme Q transmembrane electrón transport. Meth. Enzymol. 378, 207-217 (2004).

171. Cabo, R. de, Cabello, R., Rios, M., López-Lluch, G., Ingram, DK., Lane, MA. and Navas, P. The plasma membrane antioxidant system of liver is increased in aging rats by calorie restriction. Exp. Gerontol. 39, 297- 304 (2004).

172. Padilla, S., Jonassen, T., Jimenez-Hidalgo, M., Moreno, D.J., Lopez-Lluch, G., Navas, P., Clarke, C.F. and Santos-Ocaña, C. Demethoxy-Q, an Intermediate of Coenzyme Q Biosynthesis, Fails to Support Respiration in Saccharomyces cerevisiae and Lacks Antioxidant Activity. J. Biol. Chem. 279, 25995 - 26004.