Gene regulation and morphogenesis

Cell Potency Transitions

Relevant literature

Spruce T, Plass M, Gohr A, ….., Pernaute B†, Irimia M†. (2022). The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians. PLoS Biol. 20(4): e3001615. doi: 10.1371/journal.pbio.3001615. 

Gentsch GE†, Spruce T, Owens NDL, Smith JC†. (2019). Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals. Nat Commun. 19;10(1):4269. doi: 10.1038/s41467-019-12263-w.

Gentsch GE*, Spruce T, Monteiro RS*, Owens NDL, Martin SR, Smith JC†. (2018). Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus. Dev Cell. 12;44(5):597-610. doi: 10.1016/j.devcel.2018.01.022.

Pernaute B, Spruce T, Smith KM, Sánchez-Nieto JM, Manzanares M, Cobb B, Rodríguez TA†. (2014). MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM. Genes Dev. 1;28(17):1873-8. doi: 10.1101/gad.245621.114.

Spruce T, Pernaute B*, Di-Gregorio A, Cobb B, Merkenschlager M, Manzanares M†, Rodríguez TA† (2010). An early developmental role for miRNAs in the maintenance of extra-embryonic stem cells in the mouse embryo. Dev Cell19(2):207-219. doi: 10.1016/j.devcel.2010.07.014.

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