Gene regulation and morphogenesis

Cell fate determination in early mammalian development

Five relevant publications

See ORCID / Google Scholar for a complete record

* - equal contribution; † - corresponding author

  1. Pernaute B*, Sanchez-Nieto JM*, Pérez-Montero S*, di Gregorio A, Lima A,…, and Rodríguez TA† (2022). DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism. Dev Cell. un 6;57(11):1316-1330.e7
  2. Wyatt CDR*, Pernaute B*†, Gohr A, Miret-Cuesta M,…, and Irimia M† (2022). A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation. Sci Adv Apr 15;8(15):eabn4935
  3. Spruce T†, Plass M, Gohr A,…, Pernaute B† and Irimia M† (2022). The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians. Plos Biol Apr 27;20(4):e3001615
  4. Pernaute B, Spruce T, Smith KM,..., and Rodriguez TA† (2014). MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM. Genes & Dev. Sep 1;28(17):1873-8.
  5. Spruce T*, Pernaute B*, Di-Gregorio A, Cobb B, Merkenschlager M, Manzanares M†, Rodríguez TA† (2010). An early developmental role for miRNAs in the maintenance of extra-embryonic stem cells in the mouse embryo. Dev Cell. 19(2):207-19

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