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A European project coordinated by Ozren Bogdanovic at the CABD obtains more than 4 million euros to advance vertebrate tissue regeneration
published on 22/11/2024


The DANIO-ReCODE project will work on the discovery of new molecular mechanisms for tissue regeneration.
   
This initiative, coordinated from Andalusia, involves six countries: Spain, Germany, Austria, Slovenia, Croatia and the United Kingdom.

 Seville, November 22, 2024. A group of fifteen European laboratories, led by the researcher from the Andalusian Center for Developmental Biology (CABD), Ozren Bogdanovic, have obtained funding for the DANIO -ReCODE project, with a total of 4.1 million euros, of which 2.9 million come from the European contribution. The project, awarded within the HORIZON-MSCA-2023-DN-01 call, involves Germany, Austria, Slovenia, Croatia, United Kingdom and Spain, where the laboratory of María Almuedo Castillo (CABD) and Isabel Fariñas (University of Valencia) also participates.



Ozren Bogdanovic del CABD is the coordinator of the 'Danio Re-Code' project (Mar Sánchez/CSIC Andalucía)

The main objective of the DANIO-ReCODE project is to provide world-class doctoral training to a new generation of early career researchers interested in understanding the process of tissue regeneration in vertebrates. DANIO-ReCODE will combine the multidisciplinary expertise of fifteen EU and UK research laboratories to exploit the regenerative capacity of zebrafish and unravel the molecular mechanisms of heart, brain and eye regeneration. The project will also engage in the analysis of the regulation of regeneration in zebrafish relative to that of other vertebrates, including mammals.

 
A model of excellence in vertebrates for studying regeneration

Within the group of vertebrates there is variability in their regenerative capacity: while mammals have this capacity more limited, focused on some tissues or organs and to a period just after birth, other vertebrates have a high regenerative capacity, as is the case of the zebrafish. The zebrafish is able to completely regenerate several tissues and organs, such as the spinal cord, brain, cerebellum, retina, heart, kidneys and liver. Moreover, it is one of the most accessible vertebrate models for the study of regeneration, especially because of its wide variety of genetic and genomic tools, in addition to allowing screens with considerable potential for in vivo image analysis. In addition to these reasons, the research community that uses zebrafish as a study model centralizes the data obtained in platforms that allow the sharing of knowledge and resources, allowing faster progress.



Adult zebrafish (CABD)

By integrating advanced mass sequencing technologies such as genome editing, computational genomics and artificial intelligence, this project will generate genomic regulatory resources that will improve the understanding of regenerative processes in vertebrates and offer new ways to repair or replace damaged or diseased cells, organs or tissues. “This network can provide a wealth of information to advance our understanding of regeneration in vertebrates, while also advancing research into regeneration in humans,” concludes the CABD researcher coordinating the network, Ozren Bogdanovic.

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