Biología celular y Biotecnología

Regulación de la síntesis de coenzima Q y sus implicaciones en la salud mitocondrial.

Las publicaciones relevantes

  • Doimo, M., Trevisson, E., Airik, R., Bergdoll, M., Santos-Ocaña, C., Hildebrandt, F., Navas, P., Pierrel, F., and Salviati, L. (2014). Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Biochim. Biophys. Acta 1842, 1–6.
  • González-Mariscal, I., García-Testón, E., Padilla, S., Martín-Montalvo, A., Pomares-Viciana, T., Vazquez-Fonseca, L., Gandolfo-Domínguez, P., and Santos-Ocaña, C. (2014). Regulation of coenzyme Q biosynthesis in yeast: A new complex in the block. IUBMB Life n/a–n/a.
  • Heeringa, S.F., Chernin, G., Chaki, M., Zhou, W., Sloan, A.J., Ji, Z., Xie, L.X., Salviati, L., Hurd, T.W., Santos Ocaña, C., Vega-Warner, V., et al. (2011). COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121, 2013–2024.
  • Jimenez-Hidalgo, M., Santos-Ocaña, C., Padilla, S., Villalba, J.M., López-Lluch, G., Martín-Montalvo, A., Minor, R.K., Sinclair, D.A., de Cabo, R., Navas, P., et al. (2009). NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8, 140–151.
  • Martin-Montalvo, A., Gonzalez-Mariscal, I., Padilla, S., Ballesteros, M., Brautigan, D.L., Navas, P.P., and Santos-Ocana, C. (2011). Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem. J. 114, 107–114.
  • Martin-Montalvo, A., Gonzalez-Mariscal, I., Pomares-Viciana, T., Padilla-Lopez, S., Ballesteros, M., Vazquez-Fonseca, L., Gandolfo, P., Brautigan, D.L., Navas, P., Santos-Ocana, C.  (2013). The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast. J. Biol. Chem. 288, 28126–28137.
  • Padilla, S., Tran, U.C., Jiménez-Hidalgo, M., López-Martín, J.M., Martín-Montalvo, a, Clarke, C.F., Navas, P., and Santos-Ocaña, C. (2009). Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cell. Mol. Life Sci. 66, 173–186.
  • Padilla-López, S., Jiménez-Hidalgo, M., Martín-Montalvo, A., Clarke, C.F., Navas, P., and Santos-Ocaña, C.,  (2009). Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1788, 1238–1248.
  • Salviati, L., Trevisson, E., Rodriguez Hernandez, M.A., Casarin, A., Pertegato, V., Doimo, M., Cassina, M., Agosto, C., Desbats, M.A., Sartori, G., Santos-Ocaña, C., et al. (2012). Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. J. Med. Genet. 49, 187–191.