Research Groups

Cell biology and Biotechnology

Dr Carlos Santos Ocaña. UPO
Coenzyme Q synthesis in Saccharomyces cerevisae and its implication in the mitochondrial health. lifespan and ageing
Dr Carlos Santos Ocaña. UPO
Researcher associated to Dr Plácido Navas Lloret. UPO

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Most relevant publications

  1. Doimo, M., Trevisson, E., Airik, R., Bergdoll, M., Santos-Ocaña, C., Hildebrandt, F., Navas, P., Pierrel, F., and Salviati, L. (2014). Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Biochim. Biophys. Acta 1842, 1–6.
  2. González-Mariscal, I., García-Testón, E., Padilla, S., Martín-Montalvo, A., Pomares-Viciana, T., Vazquez-Fonseca, L., Gandolfo-Domínguez, P., and Santos-Ocaña, C. (2014). Regulation of coenzyme Q biosynthesis in yeast: A new complex in the block. IUBMB Life n/a–n/a.
  3. Heeringa, S.F., Chernin, G., Chaki, M., Zhou, W., Sloan, A.J., Ji, Z., Xie, L.X., Salviati, L., Hurd, T.W., Santos Ocaña, C., Vega-Warner, V., et al. (2011). COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121, 2013–2024.
  4. Jimenez-Hidalgo, M., Santos-Ocaña, C., Padilla, S., Villalba, J.M., López-Lluch, G., Martín-Montalvo, A., Minor, R.K., Sinclair, D.A., de Cabo, R., Navas, P., et al. (2009). NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8, 140–151.
  5. Martin-Montalvo, A., Gonzalez-Mariscal, I., Padilla, S., Ballesteros, M., Brautigan, D.L., Navas, P.P., and Santos-Ocana, C. (2011). Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem. J. 114, 107–114.
  6. Martin-Montalvo, A., Gonzalez-Mariscal, I., Pomares-Viciana, T., Padilla-Lopez, S., Ballesteros, M., Vazquez-Fonseca, L., Gandolfo, P., Brautigan, D.L., Navas, P., Santos-Ocana, C.  (2013). The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast. J. Biol. Chem. 288, 28126–28137.
  7. Padilla, S., Tran, U.C., Jiménez-Hidalgo, M., López-Martín, J.M., Martín-Montalvo, a, Clarke, C.F., Navas, P., and Santos-Ocaña, C. (2009). Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cell. Mol. Life Sci. 66, 173–186.
  8. Padilla-López, S., Jiménez-Hidalgo, M., Martín-Montalvo, A., Clarke, C.F., Navas, P., andSantos-Ocaña, C.,  (2009). Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1788, 1238–1248.
  9. Salviati, L., Trevisson, E., Rodriguez Hernandez, M.A., Casarin, A., Pertegato, V., Doimo, M., Cassina, M., Agosto, C., Desbats, M.A., Sartori, G., Santos-Ocaña, C., et al. (2012). Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. J. Med. Genet. 49, 187–191.