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Using the fission yeast Schizosaccharomyces pombe as our model organism our group (started very recently) tries to reveal the role that Hsp90 plays in cell cycle regulation and ageing. Using Genetics, Biochemistry and Cellular Biology techniques we analyze the effect of mutations in Hsp90 in the commitment to mitosis and cytokinesis, alone or in combination with other cell cycle mutations. We have identified physical interactions between Hsp90 and cell cycle proteins, probably reflecting the existence of Hsp90 complexes and we are now trying to purify such complexes. Finally, we are checking whether the ageing retardation effect described in C.elegans for Hsp90 mutants is a universal phenomenon also present in S.pombe. |