Research Groups

Cell biology and Biotechnology

Daniel José Moreno Fernández-Ayala
Gene expression and development in Coenzyme Q deficiency: a model to establish the origin of this mitochondrial disease
Daniel José Moreno Fernández-Ayala
Researcher associated to Dr Plácido Navas Lloret. UPO

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Relevant publications

  • Lara-Padilla, E., Campos-Rodríguez, R., Miliar, A., Reyna Garfias, H., Rivera-Aguilar, V., Jarillo-Luna, R.A., Berral de la Rosa, F.J., Navas, P., López-Lluch, G. (2011) Caloric restriction reduces the levels of IgA and modified the expression of cytokines in the small intestine of mice. J. Nutr. Biochem. 22: 560-566.
  • Parrado, C., López-Lluch, G., Rodriguez-Bies, E., Santa Cruz-Calvo, S., Navas, P., Ramsey, J.J., and Villalba, J.M. (2011) Calorie restriction modifies ubiquinone and CoQ transcript levels in mouse tissues. Free Rad. Biol. Med. 50: 1728-1736.

  • López-Lluch, G., Santa Cruz-Calvo, S., and Navas, P. (2012) Resveratrol in cancer: cellular and mitochondrial consequences of proton transport inhibition. Curr. Pharm. Des. 18: 1338-1344.

  • Chen, Y., Hagopian, K., McDonald, R.B., Bilbus, D., López-Lluch, G., Villalba, J.M., Navas, P., and Ramsey J.J. (2012) The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction. J. Gerontol A: Biol Sci. 67:1121-1131.

  • Chen, Y., Hagopian, K., Bilbus, D., Villalba, J.M., López-Lluch, G., Navas, P., Kim, K., McDonald, R.B., and Ramsey, J.J. (2013) The influence of dietary lipid composition on liver mitochodria from mice following 1 month of calorie restriction. Biosci. Rep. 33: 83-95.

  • López-Domínguez, J.A., Khraiwesh, H., González-Reyes, J.A., López-Lluch, G., Navas, P., Ramsey, J.J., De Cabo, R., Burón, M.I., and Villalba, J.M. (2013) Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie restricted mice. AGE. 35(6):2027-44.

  • Khraiwesh, H., López-Domínguez, J.A., López-Lluch, G., Navas, P., De Cabo, R., Ramsey, J.J., Villalba, J.M., and González-Reyes, J.A. (2013) Ultrastructural and dymanics changes of hepatocytes mitochondria from mice following calorie restriction with different dietary fat. J. Gerontol A: Biol. Sci. 68(9):1023-34.
  • Serrano-Bueno G, Hernández A, López-Lluch G, Pérez-Castiñeira JR, Navas P,
    Serrano A. Inorganic pyrophosphatase defects lead to cell cycle arrest and
    autophagic cell death through NAD+ depletion in fermenting yeast. (2013) J Biol Chem.
  • Khraiwesh H, López-Domínguez JA, Fernández del Río L, Gutierrez-Casado E,
    López-Lluch G, Navas P, de Cabo R, Ramsey JJ, Burón MI, Villalba JM,
    González-Reyes JA. (2014) Mitochondrial ultrastructure and markers of dynamics in
    hepatocytes from aged, calorie restricted mice fed with different dietary fats.
    Exp Gerontol. 56:77-88.

  • Tung BT, Rodríguez-Bies E, Ballesteros-Simarro M, Motilva V, Navas P,
    López-Lluch G. (2014) Modulation of endogenous antioxidant activity by resveratrol and
    exercise in mouse liver is age dependent. J Gerontol A Biol Sci Med Sci. 69(4):398-409.

  • Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K,
    Ramsey JJ. (2014) The influence of dietary lipid composition on skeletal muscle
    mitochondria from mice following eight months of calorie restriction. Physiol
    Res. 63(1):57-71.
  • Del Pozo-Cruz J, Rodríguez-Bies E, Ballesteros-Simarro M, Navas-Enamorado I,
    Tung BT, Navas P, López-Lluch G. (2014) Physical activity affects plasma coenzyme Q10
    levels differently in young and old humans. Biogerontology. 15(2):199-211.
  • Siendones E, SantaCruz-Calvo S, Martín-Montalvo A, Cascajo MV, Ariza J,
    López-Lluch G, Villalba JM, Acquaviva-Bourdain C, Roze E, Bernier M, de Cabo R,
    Navas P. (2014) Membrane-bound CYB5R3 is a common effector of nutritional and oxidative
    stress response through FOXO3a and Nrf2. Antioxid Redox Signal. 21(12):1708-25.
  • Del Pozo-Cruz J, Rodríguez-Bies E, Navas-Enamorado I, Del Pozo-Cruz B, Navas
    P, López-Lluch G. (2014) Relationship between functional capacity and body mass index
    with plasma coenzyme Q10 and oxidative damage in community-dwelling
    elderly-people. Exp Gerontol. 52:46-54.

  • Rodríguez-Bies E, Navas P, López-Lluch G. Age-dependent effect of
    every-other-day feeding and aerobic exercise in ubiquinone levels and related
    antioxidant activities in mice muscle. (2015) J Gerontol A Biol Sci Med Sci. 70(1):33-43.
  • López-Domínguez JA, Khraiwesh H, González-Reyes JA, López-Lluch G, Navas P,
    Ramsey JJ, de Cabo R, Burón MI, Villalba JM. (2015) Dietary fat and aging modulate
    apoptotic signaling in liver of calorie-restricted mice. J Gerontol A Biol Sci
    Med Sci. 70(4):399-409.

  • López-Domínguez JA, Ramsey JJ, Tran D, Imai DM, Koehne A, Laing ST, Griffey
    SM, Kim K, Taylor SL, Hagopian K, Villalba JM, López-Lluch G, Navas P, McDonald
    RB. (2014) The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice.
    J Gerontol A Biol Sci Med Sci. 2014 (in press).
  • Tung BT, Rodríguez-Bies E, Talero E, Gamero-Estévez E, Motilva V, Navas P,
    López-Lluch G. (2015) Anti-inflammatory effect of resveratrol in old mice liver. Exp
    Gerontol. 64:1-7.

  • Villalba JM, López-Domínguez JA, Chen Y, Khraiwesh H, González-Reyes JA, Del  Río LF, Gutiérrez-Casado E, Del Río M, Calvo-Rubio M, Ariza J, de Cabo R, López-Lluch G, Navas P, Hagopian K, Burón MI, Ramsey JJ. (2015) The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespa  changes in calorie-restricted mice. Biogerontology. 2015 (in press).