Research Groups

Gene regulation and morphogenesis

Prof Juan Pablo Couso. CSIC
Genetics and functional genomics of genes with small open reading frames
Prof Juan Pablo Couso. CSIC
Principal Investigator

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Five relevant publications

  • Magny, E.G.,  Platero, A.I., Bishop, S.A., Pueyo, J.I., Aguilar-Hidalgo, D. and Couso J.P. (2021) Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless. Nature Communications, 12, Article number: 5660.
  • Patraquim, P., Mumtaz, M.A.S., Pueyo, J.I., Aspden J.L and Couso J.P. (2020). Developmental regulation of canonical and small ORF translation from mRNAs. Genome Biology 21, Article number: 128.
  • Pueyo J.I., Magny E., Sampson C., Amin U., Evans I.R., Bishop S.A., and Couso J.P. (2016). Hemotin, a regulator of endocytic trafficking and phagocytosis encoded by a small ORF and conserved across metazoans, Public Library of Science, Biology, 14: e1002395.
  • Couso J.P. and Patraquim P.  (2016) “Classification and Function of small Open Reading Frames”. Analysis article in Nature Reviews Molecular and Cell Biology, 18: 575-589.
  • Aspden J.L., Chen Eyre-Walker Y., Philips R., Amin U., Mumtaz M.A., Brocard M., Couso J.P. (2014). Extensive translation of small ORFs revealed by Poly-Ribo-Seq. eLife 3: e03528.
  • Magny E., Pueyo J.I., Pearl F., Cespedes M.A., Niven J.E., Bishop S.A. and Couso J.P. (2013). Conserved regulation of calcium uptake in the heart by peptides encoded by small Open Reading Frames. Science 341:1116-1120.
  • Galindo M.I., Pueyo J.I., Fouix S., Bishop S.A. and Couso J.P. (2007) Peptides Encoded by Short ORFs Control Development and Define a New Eukaryotic Gene Family. Public Library of Science, Biology, 5: e106.