How do organs control their size?
In the lab we investigate the mechanisms that regulate organ size by studying the eyes of flies. Eyes, because they are specialized sensory structures of great biological relevance; and specifically of flies because eyes have undergone an extraordinary morphological and functional diversification within this huge insect group –the diptera. Our workhorse is the fruitfly Drosophila melanogaster, one of the most powerful model organisms, and use it as paradigm from which to explore the eyes of close and far relatives. Exploring the mechanisms of organ growth control is interesting beyond the realm of developmental and evolutionary biology, as they are relevant for understanding the causes of congenital diseases and cancer, as well as for organ engineering.
Our research uses a variety of approaches, including developmental genetics, genomics, genome editing, quantitative imaging, and mathematical modeling.
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If you are interested in joining the Casares lab, please contact Fer Casares: fcasfer@upo.es