.

Grupos de investigación

Biología celular y Biotecnología

Dr Carlos Santos Ocaña. UPO
Regulación de la síntesis de coenzima Q y sus implicaciones en la salud mitocondrial.
Dr Carlos Santos Ocaña. UPO
Researcher associated to Dr Plácido Navas Lloret. UPO

» Resumen » Las publicaciones relevantes » Miembros del laboratorio y Colaboradores » back to research groups


Las publicaciones relevantes

  1. Doimo, M., Trevisson, E., Airik, R., Bergdoll, M., Santos-Ocaña, C., Hildebrandt, F., Navas, P., Pierrel, F., and Salviati, L. (2014). Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Biochim. Biophys. Acta 1842, 1–6.
  2. González-Mariscal, I., García-Testón, E., Padilla, S., Martín-Montalvo, A., Pomares-Viciana, T., Vazquez-Fonseca, L., Gandolfo-Domínguez, P., and Santos-Ocaña, C. (2014). Regulation of coenzyme Q biosynthesis in yeast: A new complex in the block. IUBMB Life n/a–n/a.
  3. Heeringa, S.F., Chernin, G., Chaki, M., Zhou, W., Sloan, A.J., Ji, Z., Xie, L.X., Salviati, L., Hurd, T.W., Santos Ocaña, C., Vega-Warner, V., et al. (2011). COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121, 2013–2024.
  4. Jimenez-Hidalgo, M., Santos-Ocaña, C., Padilla, S., Villalba, J.M., López-Lluch, G., Martín-Montalvo, A., Minor, R.K., Sinclair, D.A., de Cabo, R., Navas, P., et al. (2009). NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8, 140–151.
  5. Martin-Montalvo, A., Gonzalez-Mariscal, I., Padilla, S., Ballesteros, M., Brautigan, D.L., Navas, P.P., and Santos-Ocana, C. (2011). Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem. J. 114, 107–114.
  6. Martin-Montalvo, A., Gonzalez-Mariscal, I., Pomares-Viciana, T., Padilla-Lopez, S., Ballesteros, M., Vazquez-Fonseca, L., Gandolfo, P., Brautigan, D.L., Navas, P., Santos-Ocana, C.  (2013). The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast. J. Biol. Chem. 288, 28126–28137.
  7. Padilla, S., Tran, U.C., Jiménez-Hidalgo, M., López-Martín, J.M., Martín-Montalvo, a, Clarke, C.F., Navas, P., and Santos-Ocaña, C. (2009). Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cell. Mol. Life Sci. 66, 173–186.
  8. Padilla-López, S., Jiménez-Hidalgo, M., Martín-Montalvo, A., Clarke, C.F., Navas, P., and Santos-Ocaña, C.,  (2009). Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1788, 1238–1248.
  9. Salviati, L., Trevisson, E., Rodriguez Hernandez, M.A., Casarin, A., Pertegato, V., Doimo, M., Cassina, M., Agosto, C., Desbats, M.A., Sartori, G., Santos-Ocaña, C., et al. (2012). Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. J. Med. Genet. 49, 187–191.