Regulación génica y morfogénesis

Desarrollo y evolución de vertebrados

Publicaciones recientes más relevantes

  • Letelier J#, Naranjo S#, Sospedra-Arrufat I, Martínez-Morales JR,  Lopez-Rios J*, Shubin N*, Gómez-Skarmeta JL* (2021). The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits. Proc Natl Acad Sci USA 118(46): e2100575118  Featured in El País (Nov 8, 2021)  > ver articulo 
     
  • Tissières V, Geier F, Kessler B, Wolf E, Zeller R, Lopez-Rios J. (2020). Gene regulatory and expression differences between mouse and pig limb buds provide insights into the evolutionary emergence of artiodactyl traits. Cell Rep 31 (1): 107490.
     
  • Osterwalder M, Barozzi I, Tissières V, Fukuda-Yuzawa Y, Mannion BJ, Afzal SY, Lee EA, Zhu Y, Plajzer-Frick I, Pickle CS, Kato M, Garvin TH, Pham QT, Harrington AN, Akiyama JA, Afzal V, Lopez-Rios J, Dickel DE, Visel A, Pennacchio LA. (2018). Enhancer redundancy provides phenotypic robustness in mammalian development. Nature, 554(7691):239-243.
     
  • Lopez-Rios J. (2016). The many lives of SHH in limb development and evolution. Semin Cell Dev Biol, 49:116-124.
     
  • Lopez-Rios J#, Duchesne A#, Speziale D, Andrey G, Peterson KA, German P, Ünal E, Liu J, Floriot S, Barbey S, Gallard Y, Müller-Gerbl M, Courtney AD, Klopp C, Rodriguez S, Ivanek R, Beisel C, Wicking C, Iber D, Robert B, McMahon AP, Duboule D and Zeller R. (2014) Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Nature, 511(7507):46-51.
     
  • Osterwalder M, Speziale S, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J* and Zeller R*. (2014). HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme. Dev Cell, 31:345 - 357.
     
  • Lopez-Rios J, Speziale D, Robay D, Scotti M, Osterwalder M, Nusspaumer G, Galli A, Holländer GA, Kmita M, Zeller R. (2012). GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis. Dev Cell, 22:837–848.
     
  • Osterwalder M, Galli A, Rosen B, Skarnes WC, Zeller R*, Lopez-Rios J*. (2010). Dual RMCE for efficient re-engineering of mouse mutant alleles. Nat Methods, 7: 893-895.

#equal contribution authors; *co-corresponding authors