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Grupos de investigación

Biología celular y Biotecnología

Gloria Brea Calvo
Fisiopatología de las deficiencias de CoQ causadas por mutaciones en COQ4
Gloria Brea Calvo
Researcher associated to Dr Plácido Navas Lloret. UPO

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Publicaciones Relevantes

  • Dogan SA, Cerutti R, Beninca C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, and Viscomi C (2018). Perturbed redox signalling exacerbates a mitochondrial myopathy. Cell Metabolism. DOI:https://doi.org/10.1016/j.cmet.2018.07.012
  • Alcázar-Fabra M, Trevisson E, Brea-Calvo G. (2018) Clinical syndromes associated with Coenzyme Q10 deficiency. Essays in Biochemistry., 62(3):377-398.
  • Yubero, D., Montero, R., Martín, M.A., Montoya, J., Ribes, A., Grazina, M., Trevisson, E., Rodriguez-Aguilera, J.C., Hargreaves, I.P., Salviati, L., Navas, P., Artuch, R.; CoQ deficiency study group (including Brea-Calvo, G). (2016) Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders. Mitochondrion, 30: 51-58.
  •  Alcázar-Fabra M, Navas P, Brea-Calvo G. (2016) Coenzyme Q biosynthesis and its role in the respiratory chain structure. Biochimica et Biophysica Acta, 1857(8): 1073-1078.
  • Cascajo MV, Abdelmohsen K, Noh JH, Fernández-Ayala DJ, Willers IM, Brea G, López-Lluch G, Valenzuela-Villatoro M, Cuezva JM, Gorospe M, Siendones E, Navas P. (2016) RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation of COQ7. RNA Biology, 13(7): 622-34.
  • Brea-Calvo G, Haack TB, Karall D, Ohtake A, Invernizzi F, Carrozzo R, Kremer L, Dusi S, Fauth C, Scholl-Bürgi S, Graf E, Ahting U, Resta N, Laforgia N, Verrigni D, Okazaki Y, Kohda M, Martinelli D, Freisinger P, Strom TM, Meitinger T, Lamperti C, Lacson A, Navas P, Mayr JA, Bertini E, Murayama K, Zeviani M, Prokisch H, Ghezzi D (2015) COQ4 Mutations Cause a Broad Spectrum of Mitochondrial Disorders Associated with CoQ10 Deficiency. American Journal of Human Genetics, 96(2): 309-317.
  • Brea-Calvo G, Siendones E, Sánchez-Alcázar JA & Navas P (2009). Cell survival from Chemotherapy depends on NF-kappaB transcriptional upregulation of Coenzyme Q biosynthesis. PLoSOne, 4(4): e5301.       
  • Artuch R, Brea-Calvo G, Briones P, Aracil A, Galvan M, Espinos C, Corral J, Volpini V, Ribes A, Andreu AL, Palau F, Sánchez-Alcázar JA, Navas P & Pineda M (2006). Cerebellar ataxia with coenzyme Q10 deficency: diagnosis and follow-up after coenzyme Q10 supplementation. J Neurol Sci, 246: 153-158.·          
  • Brea-Calvo G, Rodriguez-Hernandez A, Fernandez-Ayala DJM, Navas P & Sánchez-Alcázar JA (2006). Chemotherapy induces an increase in coenzyme Q10 levels in cancer cells lines. Free Radical Biology and Medicine, 40: 1293-1302.
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