Ofertas de empleo

Beca de tesis durante 3 años dentro del programa Marie Curie Training Network
Development and Computational Biology (DevCom)

This project aims at comparing the dynamics of cis-regulatory activity during early development of zebrafish and Xenopus and determining how evolutionary conserved regulatory elements are organized within regulatory landscapes acting on specific developmental genes. We will use available profiles of epigenetic modifications in both model systems to computationally identify an evolutionary conserved set of enhancers operating at different developmental stages. We will then identify potential chromatin loops by analysing the genome-wide distribution of CTCF binding sites at different developmental stages in zebrafish. Together, this information will help to define putative regulatory landscapes operating on different developmental genes. These landscapes, and their developmental dynamics, will be then evaluated using 4C-seq. These studies will be complemented with functional evaluation of some of the identified cis-regulatory elements using transgenic assays. More information about this and other positions vacant at DevCom and the eligibility criteria at: http://www.devcom-itn.eu/

Beca de tesis durante 3 años dentro del programa Marie Curie Training Network
Development and Computational Biology (DevCom)

This project aims to computationally extract evolutionary conserved GRNs operating at early embryogenesis. We will first generate DNAse I footprinting profiles at different zebrafish developmental stages. We will computationally compare our profiles with those generated in Xenopus embryos at the Veenstra laboratory and with the available data on the genome-wide distribution of chromatin modifications associated with promoters and enhancers in both species. These data, together with available transcriptome information and regulatory motif analysis at the regulatory sequences, will be used to extract evolutionary conserved and species‹specific subsets of regulatory networks operating at early embryogenesis. We will then use TALENs to disrupt in zebrafish some key cis-regulatory elements from these GRNs that are evolutionary conserved. In addition, we will make use of quantitative mass spectrometry to identify upstream regulators of some of the identified enhancers. Functional analysis of some of these upstream factors will be used to validate the predicted GRNs. More information about this and other positions vacant at DevCom and the eligibility criteria at: http://www.devcom-itn.eu/

4-year PhD fellowship in the CASARES laboratory at the CABD, Seville (SPAIN). Available as from Summer 2013.

We are looking for a highly motivated PhD student with an interest in organ patterning, gene regulatory networks and evolution. The research project will aim at deciphering the gene regulatory network that specifies and patterns the ocelli, simple eyes that are part of the fly’s visual system, used as a model of more complex eyes. The successful candidate will use a broad range of techniques, including genetics, genomics, quantitative imaging and modeling, and Drosophila melanogaster and other dipterans will be the experimental systems. She/he will work in close collaboration with experimentalists as well as mathematical modelers. The host laboratory has extensive experience using Drosophila as a model system and provides access to state-of-the-art scientific infrastructure. The successful candidate is expected to hold a degree in Biology, Biochemistry, Biotechnology, Physics or a related area and to be proficient in English. The fellowship runs for 4 years.

The CABD (Andalusian Center for Developmental Biology) is at the Pablo de Olavide University campus, in the city of Seville. The CABD is funded by the Spanish Research Council (CSIC), the Pablo de Olavide University and the Andalusian Regional Government, and has a vibrant, young and international scientific community. The working language at the CABD is English.

For informal enquiries, please send a copy of the CV, the academic record and the name of two referees to Dr. Fernando Casares (fcasfer(at)upo(dot)es). Further information can be found at the CABD’s webpage:
http://www.cabd.es/en-research_groups.html

A position is available for highly motivated scientists with a strong background in molecular biology and genetics. While previous experience in bioinformatics and data analysis is not necessary, this would certainly be a plus. A very good track record and at least one publication in a high profile journal are required. The position is financially supported by the European Research Council for a period of 2 years.

Research project:
Metabolic profiling of ageing: The project will imply the use of metabolomics in the model organism Caenorhabditis elegans to understand the ageing process. More details available upon request.


The laboratory is housed in the Andalusian Centre for Developmental Biology (http://www.cabd.es/en-home.html), within the University Pablo de Olavide in Seville, offering an excellent scientific environment.
Applicants should send their CV, a motivation letter and contact details for references to Marta Artal-Sanz.
Deadline for applications: August 25th, 2012

We are looking for highly motivated doctorate/master students interested in initiating a scientific career in our research group. The aim of the project is to follow an omic´s approach to characterize at the molecular and functional level foetal hemato-vascular progenitors with a specific interest in the analysis of endothelial cell function during neonatal organogenesis. The candidate would start a PhD.
WE OFFER: Position is immediately available. We offer an initial 6 months contract and the possibility of applying for fellowships. The candidate should have good grade scores.
Please send CV and letter of interest before July 31st.
Please contact and send document to:
Dra. María José Sánchez, Jefa de Grupo.
Tel.: 954348943

A PhD position is immediately available for highly motivated students with strong background in molecular biology and genetics. The position is supported by the European Research Council for a period of 4 years.

Research project: The project aims at understanding the communication between cellular signalling networks and mitochondrial function in the regulation of aging, using the nematode C. elegans.

The laboratory is housed in the Andalusian Centre for Developmental Biology (http://www.cabd.es/en-home.html), within the University Pablo de Olavide in Seville, offering an excellent scientific environment.

Applicants should send their CV and a motivation letter to Marta Artal-Sanz. Recommendation letters or contact details for references are not mandatory but will be an advantage.
Deadline for applications: May 15th, 2012

El objetivo de este proyecto es entender cómo los tejidos interpretan transcripcionalmente la tensión mecánica a la que se ven sometidos durante su morfogénesis, y qué papel tiene esta respuesta en el auto-ensamblaje de órganos. Como modelos genéticos se emplearan los peces medaka y zebrafish. Se pretende llevar a cabo una aproximación a escala genómica para identificar y estudiar funcionalmente, en el contexto de los tejidos, los genes y las regiones cis-reguladoras activadas por tensión.
Incorporación Marzo de 2012 (negociable). Se cuenta con financiación inicial del doctorando a través de una beca de iniciación a la investigación de tres meses.
Requisitos:
-Licenciados (o alumnos de último curso) en Biología, Biotecnología, Ciencias Ambientales, Química o carreras afines.
-Tener buen expediente académico (>2.3).
-Se valorará positivamente la motivación, la experiencia previa en investigación (laboratorio) y la acreditación en Masters y otros cursos de formación.
Interesados enviar CVs por este vínculo.

We are looking for independent group leaders with a strong record in developmental biology.

There is an open deadline. Candidates should submit an expression of interest letter. Selected candidates will be invited for an interview where they will present their past achievements and their future research program. Short listed candidates will be encouraged to officially apply for a permanent position funded by the National research council CSIC. Typically, there is one such position offered every year.

Contratos Ramón y Cajal: 5 year career development awards for senior postdocs.

Ramón y Cajal Fellows may be considered Principal Investigators if approved by our scientific advisory panel (For further information contact the CABD director or any PI you are interested collaborating with).

Contratos Juan de La cierva: Three year fellowships for junior postdocs working in the group of a CABD Principal Investigator (Contact specific PI you are interested collaborating with).