Research groups

Gene regulation and morphogenesis

Molecular embryology: Functional genomics, mouse transgenesis and the formation of skeletal muscle

Dr Jaime Carvajal. CSIC
Principal Investigator

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Relevant publications

Soleimani, V. D., Punch, V. G., Kawabe, Y., Jones, A. E., Carvajal, J. J., Palidwor, G., Porter, C. J., Kockx, C. E. M., van IJcken, W. F. J., Perkins, T. J., Rigby, P. W. J., Grosveld, F., and Rudnicki, M. A. (2012) Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs. Developmental Cell (in press).
Moncaut, N., Cross, J. W., Siligan, C., Keith, A., Taylor, K., Rigby, P. W. J., Carvajal, J. J. (2012) Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development. Development, 139, 958-67.
Ribas R., Siligan C., Taylor K., Rigby P.W.J., and Carvajal J.J. (2011). Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. Developmental Biology. 355, 372-380.
Villarejo-Balcells B., Rigby P.W.J. and Carvajal J.J. (2011). Expression pattern of the FoxO1 gene during embryonic development. Gene Expression Patterns. 11, 299-30.
Carvajal J.J. and Rigby P.W.J. (2010). Transcriptional control of myogenesis. Experimental Cell Research. 316, 3014-3018.
Carvajal J.J., Keith A. and Rigby P.W.J. (2008). Global transcriptional regulation of the locus encoding the skeletal muscle determination genes Mrf4 and Myf5. Genes and Development. 22, 265-276.
Carvajal J.J. Cox D., Summerbel D., and Rigby P.W.J. (2001). A BAC transgenic analysis of the Mrf4 /Myf5 locus reveals interdigitated elements which control activation and maintenance of gene expression during muscle development. Development. 128, 1857-1868.