Research groups

Gene regulation and morphogenesis

Dr Juan Ramón Martínez Morales. CSIC
Control of epithelial morphogenesis in vertebrates
Dr Juan Ramón Martínez Morales. CSIC
Principal Investigator

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Relevant publications

Relevant publications

• Letelier J#, de la Calle-Mustienes E#, Pieretti J, Naranjo S, Maeso I, Nakamura T, Pascual-Anaya J, Shubin NH*, Schneider I*, Martinez-Morales JR*, Gómez-Skarmeta JL*. (2018)  A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins. Nature Genetics 50(4):504-509 doi: 10.1038/s41588-018-0080-5.

• Letelier J#, Terriente J#, Belzunce I, Voltes A, Undurraga CA, Polvillo R, Devos L, Tena JJ, Maeso I, Retaux S, Gomez-Skarmeta JL, Martínez-Morales JR*, Pujades C* (2018) Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. PNAS 115(16):E3731-E3740. doi: 10.1073/pnas.1719885115.

• Nicolás-Pérez M, Kuchling F, Letelier J, Polvillo R, Wittbrodt J, Martínez-Morales JR.(2016) Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis. eLife. 2016 Oct 31;5. pii: e15797. doi: 10.7554/eLife.1

• Gago-Rodrigues I, Fernández-Miñán A, Letelier J, Naranjo S, Tena JJ, Gómez-Skarmeta JL, Martinez-Morales JR (2015) Analysis of opo cis-regulatory landscape uncovers Vsx2 requirement in early eye morphogenesis. Nat Comm  6:7054. doi: 10.1038/ncomms8054.

• Tena JJ#, González-Aguilera C#, Fernández-Miñán A, Vázquez-Marín J, Parra-Acero H, Cross JW, Rigby PW, Carvajal JJ, Wittbrodt J, Gómez-Skarmeta JL*, Martínez-Morales JR* (2014) Comparative epigenomics in distantly related teleost species identifies conserved cis-regulatory nodes active during the vertebrate phylotypic period. Genome Research. 24(7): 1075-85

• Muller C#, Maeso I#, Wittbrodt J*, Martínez-Morales JR* (2013) The medaka mutation tintachina sheds light on the evolution of V-Atpase B subunits in vertebrates. Scientific Reports 3. 3217

• Bogdanovic O#, Delfino-Machín M#, Nicolás-Pérez M, Gavilán MP, Gago-Rodrigues I, Fernández-Miñán A, Lillo C, Ríos RM, Wittbrodt J, Martínez-Morales JR# (2012) Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis. Developmental Cell. 23 (4)

• Souren M#, Martinez-Morales JR*#, Makri P, Wittbrodt B, Wittbrodt J* (2009) A global survey identifies novel upstream components of the Ath5 neurogenic network. Genome Biology 10(9): R92.

• Martinez-Morales JR*, Rembold M, Greger K, Simpson JC, Brown KE, R Quiring R, Martin-Bermudo MD, Himmelbauer H, Pepperkok R, Wittbrodt J* (2009) Ojoplano-mediated basal constriction is essential for optic cup morphogenesis. Development 136(13): 2165-75.


*Co-corresponding authors. #equal contribution.

Full list of publications.