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Universidad Pablo de Olavide Junta de Andalucía Consejo Superior de Investigaciones Científicas

Research groups

Cell biology and Biotechnology

Dr Guillermo López Lluch. UPO
Caloric restriction: bioenergetics, oxidative damage and aging
Dr Guillermo López Lluch. UPO
Researcher associated to Dr Plácido Navas Lloret. UPO

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Relevant publications

  • De Cabo, R., Cabello, R., Rios, M., López-Lluch, G., Ingram, D.K., Lane, M.A., and P. Navas (2004) The plasma membrane antioxidant system of liver is increased in aging rats by calorie restriction. Exp Gerontol. 39: 297-304.
  • Fernández-Ayala, D.J.M., López-Lluch, G., García-Valdés, M., Arroyo, A., and Navas, P. (2005) Specificity of coenzyme Q10 for a balanced function of respiratory chain and endogenous ubiquinone biosynthesis in human cells. Biochem. Biophys. Acta: Bioenergetics. 1706: 174-183.
  • Fernández-Ayala, D.J.M., Brea-Calvo, G., López-Lluch, G. and Navas, P. (2005) Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system. Biochem. Biophys. Acta: Biomembranes. 1713: 129-137.
  • López-Lluch, G., Ríos, M., Lane, M.A., Navas, P., and De Cabo, R. (2005) Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction. AGE 27, 153-160.
  • López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S,. Cascajo, M.V., Allard, J., Ingram, D.K., Navas P., and De Cabo, R. (2006) Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. USA 103:1768-1773.
  • Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Pranbhu, V.V., Allard, J.S., López-Lluch, G., Lewis, K., Pistell, P., Poosala, S., Puigserver, P., Ingram, D.K., De Cabo, R., and Sinclair, D.A. (2006) Resveratrol mimics a low calorie diet and extends lifespan in mice. Nature 444: 337-342.
  • Fontán-Lozano, A., Sáiz-Cassanelli, J., Inda, N.C., De los Santos-Arteaga, M., Sierra-Domínguez, S., López-Lluch G., Delgado, J.M. and Carrión, A. (2007) Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunit of the NMDA receptor. J. Neurosci. 27: 10195-10195.
  • López, S., Bermúdez, B., Pacheco, Y.M., López-Lluch, G., Moreda, W., Villar, J., Abia, J., and Muriana, F.J.G. (2007) Dietary oleic and palmitic acids modulate the ratio of triacylglycerols to cholesterol in postprandial triacylglycerol-rich lipiproteins in men and cell viability and cycling in human monocytes. J. Nutr. 137: 1999-2005.
  • Hernández, A., López-Lluch, G., Bernal, J.A., Navas, P. and Pintor-Toro, J.A. (2008) Dicoumarol downregulates human PTTG/Securin mRNA expression through inhibition of Hsp90. Mol. Cancer Ther. 7: 474-482.
  • López-Lluch G., Irusta, P.M., Navas, P., and De Cabo, R. (2008) Mitochondrial biogenesis and healthy aging. Exp. Gerontol. 47: 813-819.
  • Fontán-Lozano, A. López-Lluch, G., Delgado-García, J.M., Navas, P., and Carrión, A.M. (2008) Molecular bases of caloric restriction regulation of neuronal synaptic plasticity. Mol. Neurobiol. 38: 167-177.
  • Ortiz, T., Burguillos, M.A., López-Lluch, G., Navas, P., Herrador, M., González, I., and Piñero, J. (2008) Enhanced induction of apoptosis in radio-resistant bladder tumour cell line by combined treatments with X-rays and worthmannin. Rad. Environ. Biophys. 47: 445-452.
  • Hernández, A., López-Lluch, G., Navas, P., and Pintor-Toro, J.A. HDAC and Hsp90 inhibitors down-regulate PTTG1/Securin but do not induce aneuploidy. (2009) Genes, Chromosomes and Cancer. 48: 194-201.
  • Paclet, M.H., Davidson-Moncada, J.D., López-Lluch, G., Shao, D., and Dekker, L.V. (2009) Protein kinase C as an effector of lipid derived second messengers. In: Lipid signalling protocols (Larijani, N., Woscholski, R., and Roser, C.A. eds). pp253-263. Humana Press (Springer). Estados Unidos.
  • Rodríguez-Bies, E., Santa-Cruz Calvo, S., Navas, P., and López-Lluch, G. (2009) Resveratrol: an ergogenic compound. Rev. Andal. Med. Deporte 2: 12-18.
  • Jiménez-Hidalgo, MK., Sántos-Ocaña, C., Padilla, S., Villalba, J.M., López-Lluch, G., Martín-Montalvo, A., Sinclair, D.A., De Cabo, R., and Navas, P. (2009) NQR1 controls lifespan by reguylating the promotion of respiratory metabolism in yeast. Aging Cell 8: 140-151.
  • González, R., Ferrín, G., Hidalgo, A.B., Ranchal, I., López-Cillero, P., Sántos-González, M., López-Lluch, G., Briceño, J., Gómez, M.A., Poyato, A., Villalba, J.M., Navas, P., De la Mata, M., and Muntané, J. (2009) N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by D-galactosamine in primary culture of human hepatocytes. Chem-Biol. Interact. 181: 95-106.