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Research groups

Gene regulation and morphogenesis

Dr Jose Luis Gómez-Skarmeta. CSIC
Functional genomics studies to unravel development, evolution and human genetic diseases
Dr Jose Luis Gómez-Skarmeta. CSIC
Principal Investigator

» Summary » Five relevant publications » Lab members & Collaborators » 1st International CABD Course on Developmental Biology and Functional Genomics » back to research groups


Five relevant publications

1. Bogdanovic O, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van  Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra JGC, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen, Gómez-Skarmeta JL, Lister R. Active DNA demethylation during the vertebrate phylotypic period.  Nature Genet.  48,417-26 (2016).

2. Acemel RD, Tena JJ, Irastorza I, Marlétaz F, Gómez-Marín C, de la Calle-Mustienes E, Bertrand S, Diaz S, Aldea D, Aury J-M, Mangenot S, Holland PWH, Devos DP, Maeso I, Escrivá H, Gómez-Skarmeta JL.  A single 3D chromatin compartment in amphioxus reveals stepwise evolution of vertebrate Hox bimodal regulation. Nature Genet. 48,336-41 (2016).

3. Gómez-Marín C, Tena JJ, Acemel RD, López-Mayorga M, Naranjo S, de la Calle-Mustienes E, Maeso I, Beccari L, Aneas I, Vielmas E, Bovolenta P, Nobrega MA, Carvajal J, Gómez-Skarmeta JL. Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proc. Natl. Acad. Sci. USA 112, 7542-7548 (2015).

4. Cebola I, Rodríguez-Seguí SA, Cho CH, Bessa J, Rovira M, Luengo M, Chhatriwala M, Berry A, Ponsa-Cobas J, Maestro MA, Jennings RE, Pasquali L, Morán I, Castro N, Hanley NA, Gomez-Skarmeta JL, Vallier L, Ferrer J. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat. Cell Biol. 7, 615-626 (2015).

5. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son  JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gómez-Skarmeta JL, Nóbrega MA. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371-5 (2014).