Research groups

Cell biology and Biotechnology

Regulation of hematopoietic stem cell differentiation during development

Dr María José Sánchez Sanz. CSIC
Principal Investigator

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Five relevant publications

Sanchez M.J., Holmes A., Miles C. and Dzierzak E. (1996). Characterization of the first definitive hematopoietic stem cells in the AGM and the liver of the mouse embryo. Immunity 5, 513-525.
Sanchez M.J, Gottgens B, Sinclair A.M, Stanley M., Begley C.G., Hunter S., Green A.R.(1999). An SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors. Development 126, 3891-904.
Sánchez M.J., Bockamp E., Miller J., Gambardella L. and Green A.R. (2001). Selective rescue of early haematopoietic progenitors in SCL-/-mice by expressing SCL under the control of a stem cell enhancer. Development, 128, 4815-4827.
de Bruijn M., Ma X., Robin C., Ottersbach K., Sanchez M.J. and Dzierzak E. (2002). Hematopoietic stem cells localize within the endothelial cell layer in the Midgestation mouse aorta. Immunity, 16, 673-683.
Gottgens B, Broccardo C, Sanchez MJ, Deveaux S, Murphy G, Gothert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, BartonLM, Knezevic K, Erber WN, Begley CG, Frampton J, Green AR. 1. (2004). The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol. 24, 1870-83.
Silberstein L, Sanchez MJ, Socolovsky M, Liu Y, Hoffman G, Kinston S, Piltz S, Bowen M, Gambardella L, Green AR, Gottgens B. (2005). Transgenic Analysis of the SCL +19 Stem Cell Enhancer in Adult and Embryonic Haematopoietic and Endothelial Cells. Stem Cells 23, 378-88.