.

Placido Navas CV 2014


CURRICULUM VITAE

Plácido Navas
Professor of Cell Biology
Centro Andaluz de Biología del Desarrollo (CABD)
Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER)
Instituto de Salud Carlos III
Universidad Pablo de Olavide-CSIC
Sevilla, Spain
www.upo.es/CABD

EDUCATION

Graduated at the Sevilla University
PhD at the Sevilla University, 1978
Postoctoral in Purdue University, Indiana, USA 1984-86

Professional experience

Assistant Professor, Sevilla University, 1976-78
Associate Professor, Sevilla University, 1979-82
Associate Professor, Cordoba University, 1983
Postdoctoral Fullbright Fellowship, Purdue University, 1984-86
Associate Professor, Cordoba University, 1987
Professor, Cordoba University, 1988-1997
Professor, CABD, Universidad Pablo de Olavide November 1997-present
PhD Award, Sevilla University, 1979
Co-Organizer: NATO Advanced Research Workshop, Plasma Membrane Oxidoreductase in Control of Animal and Plant Growth, Córdoba, Spain, March 21-25, 1988
Co-Chairman: NATO/ASCB Joint Meeting, Molecular Mechanisms of Membrane Traffic, Airlie Conference Center, Virginia, USA, May 9-13, 1992
Co-Organizer: Advanced Research Workshop, Molecular Biology and Function of Plasma Membrane Redox, Córdoba March 22-25, 1994
Coordinator, Integrated Actions Spain-Germany between University of Hamburgo and Cordoba University, 1991-1995
President Organizer Committee of VII Congreso Nacional de la SEBC. Cordoba, 1997.
Member of the American Society of Biochemistry and Molecular Biology
Member of the International CoQ10 Association
Chairman of  Departamento de Biología Celular, Universidad de Córdoba, 1987-1990 y 1994-1997
Vicerrector of Research, Cordoba University, 1990-1994
Vicerrector de Investigación, Universidad Pablo de Olavide Sevilla, 1998-2001
Adjunct Professor, Department of Foods and Nutrition, Purdue University, Indiana, USA, 1995-2000
Member of the Advisory Committee no. 3 (Cellular and Molecular Biology)  of the National Committee of Scienctific Evaluation, 1997-1998
Miembro del Comité Ejecutivo de la International Coenzyme Q10 Association, 2002-2012
Chairman of the International Coenzyme Q10 Association, 2013-actual
Vicerrector of Academic Affairs and Posgrade, Universidad Internacional de Andalucía, 2007-2013
 PROTOPLASMA, Editor, 1994-2000
Journal of Gerontology, Biological Sciences, Co-Deputy Editor, 2008-actual
Invited Editor, volume 5, 2014 of Molecular Syndromology: Coenzyme Q10 Deficiency.


PUBLICATIONS

1 Zamorano, C., J.L. López-Campos, P. Navas, G.Sánchez and L. Díaz-Flores:"Epidermic xantophores in the Lacerta lepida". Morf. Norm. Patol. A1, 309-319 (1977).

2 López-Campos,J.L., J. Aznar, J. Piñero, J.M. López-Muñoz and P. Navas: "Influence of fasting and total water restriction on cortical of rat kidneand". Morf. Norm. Patol. A2, 497-512 (1978).

3 López-Campos, J.L., J. Aznar, J.M. López-Muñoz, J. del Prado, C. Zamorano, J.R. Alemany, P. Navas and J. Piñero: "Renal effects of prolonged management with bumetanide and furosemide in guinea pig". Morf. Norm. Patol. B2, 243-259 (1978).

4 Navas, P., L. Díaz-Flores, G. Sánchez, C. Zamorano and J.L. López-Campos: "Morphology and development of a type of mixtiform gland in the skin of Rana ridibunda". Morf. Norm. Patol. A2, 91-104 (1978).

5 Navas, P., J.L. López-Campos and L. Díaz-Flores: "Ultrastructure of the cell components in the mucous glands of Bufo calamita". Morf. Norm. Patol. A3, 41-49 (1979).

6 Navas, P., L. Díaz-Flores and J.L. López-Campos: "Ultrastructural modifications of secretory granules in serous glands from Bufo calamita". Morf. Norm. Patol. A3, 15-22 (1979).

7 Navas, P., J. Hidalgo, Ch. Bueno and J.L. López-Campos: "Histochemical analysis of the lingual glands in Columba columba". Arch. Biol. (Bruxelles) 90, 437-444 (1979)..

8 Navas, P., Ch. Bueno, J. Piñero, J. Aijon and J.L. López-Campos: "Histochemical analysis on salivary glands of Columba columba. Anterior mandibular gland". Morf. Norm. Patol. A4, 525-531 (1980).

9 Lara, J. T. Ortiz, P. Navas, J. Aijon and J.L. López-Campos: "The carp optic tectum. A Golgi-Colonnier study". Morf. Norm. Patol. A4, 213-223 (1980).

10 Sánchez, I., J. Piñero, J. Hidalgo, P. Navas, J. Aijon and J.L. López-Campos: "Ultraestructure of the kidney in Helix aspersa". Morf. Norm. Patol. A4, 243-255 (1980).

11 Navas, P., J.L. López-Campos and L. Díaz-Flores: "Epidermical differences on the granular stratum of Rana ridibunda and Bufo calamita". Morf. Norm. Patol. A4, 313-321 (1980).

12 Navas, P., J. Hidalgo, J. Aijon and J.L. López-Campos: "Histochemical study on the tongue of Rana ridibunda (Anuran,  Amphibian)". Folia. Histochem. Cytochem. 19, 39-46 (1981).

13 López-Muñoz, J.M., I. Martín, P. Navas, C. Zamorano and J.L. López-Campos: "Ultrastructural study of the optic nerve fibers of Sepia officinalis". Morf. Norm. Patol. A5, 139-148 (1981).

14 Aguirre, J.A., P. Navas, J. Piñero, J. Aijon and J.L. López-Campos: "Myofilaments in muscle fibre of Allolobophora chlorotica sav. (Annelida, Oligochaeta)". Morf. Norm. Patol. A5, 231-242 (1981).

15 Domínguez, E., P. Navas, J. Hidalgo, J. Aijon and J.L. López-Campos: "Mucous glands of the skin of Rana ridibunda. A histochemical and ultrastructural study". Basic Appl. Histochem. 25, 15-22 (1981).

16 Bueno, Ch., P. Navas, J.A. Aguirre, J. Aijon and J.L. López-Campos: "Skin mucous glands of Pleurodeles waltlii mich. Histochemical and ultrastructural study". Arch. Biol. (Bruxelles) 92, 67-72 (1981).

17 Bueno, Ch., P. Navas, J. Aijon and J.L. López-Campos: "Glycoconjugates in the epidermis of Pleurodeles waltlii". J. Ultrastruct. Res. 77, 354-359 (1981).

18 Moreno, J., J. Piñero, J. Hidalgo, P. Navas, J. Aijon and J.L. López-Campos: "Histochemical and ultrastructural studies on the salivary glands of Helix aspersa (Mollusca)". J. Zool. 196, 343-354 (1982).

19 López-Campos, J.L., J. Piñero, J. Lasierra, P. Navas, J. Moreno and R. Cobo: "Modificaciones de los mucopolisacáridos and alteraciones ultraestructurales en la ateromatosis experimental". Rev. Clínica Española. 165, 15-21 (1982). España. A.

20 Velasco, A., P. Navas, Ch. Bueno and J.L. López-Campos:  "Carbohanddrate cytochemistry on hypodermic lymphatic endothelium of the green lizard, Lacerta hispanica". Histochem. J. 14, 943-947 (1982).

21 Moreno, F.J., J. Hidalgo, J. Piñero, P. Navas, J. Aijon and J.L. López-Campos: "Cellular types in the digestive gland of Helix aspersa (Gastropod, Pulmonate)". Morf. Norm. Patol. A6, 153-168 (1982).

22 Sánchez, I., J. Hidalgo, P. Navas, J. Aijon and J.L. López-Campos: "Histochemical study of the kidney sac in Helix aspersa". Morf. Norm. Patol. A6, 345-351 (1982).

23 Navas, P., Ch. Bueno, J. Hidalgo, J. Aijon and J.L. López-Campos: "Secretion and secretory cycle of tegumentary serous glands in Pleuredeles waltlii Mich". Basic Appl. Histochem. 26, 7-15 (1982).

24 Calvo, P., A. Torres, P. Navas and J. Pérez-Silva: "Complex carbohydrates in the cyst wall of Histriculus similis". J. Gen. Microbiol. 129, 829-832 (1983).

25 Espuelas, G.M., P. Navas, Ch. Bueno, J. Hidalgo and J.L. López-Campos: "Glycoconjugates cytochemistry in the epidemis of Candprinus carpio L.". Arch. Biol. (Bruxelles) 95, 139-152 (1984).

26 Amores, P., J. Hidalgo, P. Navas, I. Sánchez-Aguaando and J.L. López-Campos: "Cellular types in the gill arch of the teleost Candprinus carpio (Candprinidae, pisces). A. histochemical and ultrastructural study". Basic Appl. Histochem. 28, 291-307 (1984).

27 Navas, P., J.M. Villalba and G. García-Herdugo: "Carbohydrate cytochemistry on the cell surface coat of amphibian keratinocytes during differentiation". Z. mikrosk.-anat. Forsch. 99, 447-454 (1985).

28 Navas, P., I.L. Sun, D.J. Morré and F.L. Crane: "Decrease of NADH in HeLa cells in the presence of transferrin or ferricyanide". Biochem. Biophys. Res. Commun. 135, 110-115 (1986).

29 Navas, P., N. Minnifield, I.L. Sun and D.J. Morré: "NADP phosphatase as a marker in free-flow electrophoretic separations for cisternae of the Golgi apparatus midregion". Biochim. Biophys. Acta 881, 1-9 (1986).

30 Sun, I.L., P. Navas, F.L. Crane, J.AND. Chou and H. Löw: "Transplasmalemma electron transport is changed in simian virus 40 transformed liver cells". J. Bioenerg. Biomembr. 18, 471-485 (1986).

31 Navas, P., A. Hidalgo and G. García-Herdugo: "Cytokinesis in onion roots: inhibition by vanadate and caffeine". Experientia 42, 437-439 (1986).

32 González-Reyes, J.A., P. Navas and G. García-Herdugo: "An Ultrastructural study of cell plate modifications induced by 2,6-Dichlorobenzonitrile in onion root meristems". Protoplasma 132, 172-178 (1986).

33 Minnifield, N., K.E. Creek, P. Navas and D.J. Morré: "Involvement of cis and trans Golgi apparatus elements in the intracellular sorting and targeting of acid hydrolases to lysosomes". Eur. J. Cell Biol. 42, 92-100 (1986).

34 Löw, H., I.L. Sun, P. Navas, C. Grebing, F.L. Crane and D.J  Morré: "Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system". Biochem. Biophys. Res. Commun. 139, 1117-1123 (1986).

35 Morré, D.J., P. Navas, C. Penel and F. Castillo: "Auxin - stimulated NADH oxidase (semidehydroascorbate reductase ) of soybean plasma membrane: role in acidification of cytoplasm?". Protoplasma 133, 195-197 (1986).

36 Villalba, J.M., P. Navas and G. García-Herdugo: "Lectin binding patterns in amphibian epidermis". Acta histochem. 81, 51-57 (1987).

37 Moya, L., F. Guerrero, P. Navas and G. García-Herdugo: "GNRH induces activation of Leydig-like cells in Pleurodeles waltlii. A morphometric study". Histol. Histopath. 2, 193-198 (1987).

38 Burón, M.I., G. García-Herdugo and P. Navas: "Sodium pump as defined by K+-stimulated p-nitrophenyl phosphatase shows a gradient from inner to outer surface in frog epidermis". Ephitelia 1, 75-83 (1987).

39 Navas, P., J.M. Villalba, M.I. Burón and G. García-Herdugo: "Lectins as markers for plasma membrane differentiation of amphibian keratinocytes". Biol. Cell 60, 225-234 (1987).

40 Sun, I.L., P. Navas, F.L. Crane, D.J. Morré and H. Löw: "Diferric transferrin reductase in the plasma membrane is inhibited by adriamycin". Biochem. Inter. 14, 119-127 (1987).

41 Sun, I.L., P. Navas, F.L. Crane, D.J. Morré and H. Löw: " NADH diferric transferrin reductase in liver plasma membrane". J. Biol. Chem. 262, 15915-15921 (1987).

42 Burón, M.I., P. Navas, G. García-Herdugo and D.J. Morré: "Isolation of plasma membrane from amphibian epidermis: evidence for a basal-to-apical charge and activity gradient". Eur. J. Cell Biol. 44, 176-186 (1987).

43 Burón, M.I., G. García-Herdugo and P. Navas: "Lectin inhibition and kinetics of microsomal K+-dependent p-nitrophenyl phosphatase of frog epidermis". Comp. Biochem. Physiol. 86, 241-244 (1987).

44 Morré, D.J., F.L. Crane, I.L. Sun and P. Navas: "The role of ascorbate in biomembrane energetics". Ann. N.Y. Acad. Sci. 498, 153-171. (1987).

45 Crane, F.L., H. Löw, I.L. Sun, P. Navas and D.J. Morré: "Redox control of cell growth". En: Redox functions of the eukariotic plasma membrane". Ed. J.M. Ramirez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 3-17 (1987).

46 Morré, D.J., P. Navas and F.L. Crane: "Isolation, purification, evaluation and quantitation of plasma membranes from tissues and cultured cells: methods and applications to cell-free sYstems for analysis of growth processes". En: Redox fuctions of the eukaryotic plasma membrane. Ed. J.M. Ramírez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 93-115 (1987).


47 Navas, P., I. L. Sun, F.L. Crane and D.J. Morré: "Changes in the pyridine nucleotide pools of HeLa cells in response to growth promoting agents". En: Redox functions of the eukayotic plasma membrane. Ed. J.M. Ramírez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 51-64 (1987).

48 Sun, I.L. and P. Navas: "Transplasma membrane diferric transferrin reductase: control band antitumor drugs". En: Redox functions of the eukaryotic plasma membrane. Ed. J.M. Ramírez, Consejo Superior de Investigaciones Científicas, Madrid. pp. 67-89 (1987).

49 Sun, I.L., P. Navas, D.J. Morré and F.L. Crane: "Modification of pyridine nucleotide pools in HeLa cells grown under growth promoting factors". Ind. Acad. Sci. 96, 377-384 (1987).

50 Navas, P., D. Nowack and D.J. Morré: "Insolation of highly purified plasma membrane from hepatomas and cultured cells by two-phase partition". In: Cell-free analysis of membrane traffic. Eds. D.J. Morré, K.E. Howell, G.M.W. Cook and W.H. Evans. Alan R. Liss, New York. pp. 237-241 (1988).

51 Burón, M.I., P. Navas, G. García-Herdugo and D.J. Morré: "Plasma membranes from amphibian epidermis: subfractionation by preparative free-flow electrophoresis". In: Cell-free analysis of membrane traffic. Eds. D.J. Moré, K.E. Howell, G.M.W. Cook and W.H. Evans. Alan R. Liss, New York. pp. 69-73 (1988).

52 Hidalgo A., P. Navas and G. García-Herdugo: "Growth inhibition induced by vanadate in onion roots". Env. Exp. Bot. 28, 131-136 (1988).

53 Gacía-Herdugo, G., J.A. González-Reyes, F. Gracia-Navarro and P. Navas: "Growth kinetics of the Golgi apparatus during the cell cycle in onion root meristems". Planta 175, 305-312 (1988).

54 Navas, P., A. Estévez, M.I. Burón, J.M. Villalba and F.L. Crane: "Cell surface glycoconjugates control the activity of the NADH-ascorbate free radical reductase of rat liver  plasma membrane". Biochem. Biophys. Res. Commun. 154, 1029-1033 (1988).

55 Burón, M.I. and P. Navas: "Thyroxin specifically stimulates anuran larvae epidermal sodium pump during metamorphosis". Comp. Biochem. Physiol. 91A, 693-695 (1988).

56 Morré, D.J., D. Nowack. G. Matyas, D.A. Werderitsh and P. Navas: "The Golgi apparatus and neoplasia". En: "Biomembranes. Basic and Medical Research". Eds. Gh. Benga and J.M. Tager. Springer, New York, pp. 130-152(1988).


57 González-Reyes, J.A., F. Gracia-Navarro, G. García-Herdugo and P. Navas: "Changes of dictyosome ultrastructure during the cell cycle in onion root meristematic cells. A morphometric and stereological study". Protoplasma 146, 35-40 (1988).

58 Navas, P., I.L. Sun, D.J. Morré and F.L. Crane: "Relationship between NAD+/NADH levels and animal cell growth". En : Plasma membrane oxidoreductase in control of animal and plant growth. Eds. F.L. Crane et al. Plenum Press, New York, pp. 339-347 (1988).

59 Navas, P., A. Estévez, J.M. Villalba and M.I. Burón: “Role of cell surface on NADH-MDHA-oxidoreductase: lectin inhibition”. En : Plasma membrane oxidoreductase in control of animal and plant growth. Eds. F.L. Crane et al. Plenum Press, New York, pp. 42 (1988).

60 Hidalgo, A. and P. Navas: “Ascorbate free radical involvement in elongation-related growth processes in onion roots”. En : Plasma membrane oxidoreductase in control of animal and plant growth. Eds. F.L. Crane et al. Plenum Press, New York, pp. 428 (1988).

61 González-Reyes, J.A., F. Gracia-Navarro, G. García-Herdugo, A. Hidalgo and P. Navas: "Differential morphometric values induced in Golgi apparatus of higher plant cells band aldehyde and permanganate fixation". J. Elect. Microsc. Tech. 11, 1-8 (1989).

62 Villalba, J.M. and P. Navas: "Polarization of plasma membrane glycoconjugates in amphibian epidermis during metamorphosis". Hitochemistry 90, 453-458 (1989).

63 Navas, P, D.D. Nowack, and D.J. Morré : "Isolation of purified plasma membranes from cultured cells and hepatomas band two-phase partition and preparative free-flow electrophoresis". Cancer Res. 49, 2147-2156 (1989).

64 Velasco, A., J. Hidalgo, J. Pérez-Vilar, G. García-Herdugo and P. Navas: "Detection of glycosaminoglycans in the Golgi complex of chondrocytes". Eur. J. Cell Biol. 47, 241-250 (1989).

65 Burón, M.I., J.M. Villalba and P. Navas: "NADH-ascorbate free radical reductase of rat liver plasma membrane: kinetics and lectin inhibition. Epithelia 1, 295-306 (1989).

66 Hidalgo, A., J.A. González-Reyes, P. Navas and G. García-Herdugo: "Abnormal mitosis and growth inhibition in Allium cepa roots induced by propham and chloropropham". Cytobios 57, 7-14 (1989).

67 Hidalgo, A., J.A. González-Reyes and P. Navas: "Ascorbate free radical enhaces vacuolization in onion root meristems". Plant Cell Environ. 12, 455-460 (1989).

68 Navas, P. and M.I. Burón: "Roles of pyridine nucleotides in the control of cell growth". In: Oxidoreduction at the Cell Membranes : Relation to growth and transport. Vol. I: Animals. Eds. F.L. Crane, D.J. Morré, H. Löw. CRC Press, Boca Raton, pp. 225-236 (1990).

69 Navas, P.: "Ascorbate free radical (semidehydro-) reductase of plant plasma membranes". In: Oxidoreduction at the cell membranes: Relation to growth and transport. Vol. II Plants. Eds. F.L. Crane, D.J. Morré, H. Löw. CRC Press, Boca Ratón, pp. 111-120 (1991).

70 Hidalgo, A., José A. González-Reyes and P. Navas.: "Protective effects of ascorbate free radical against caffeine and dichlobenil action in onion roots". Cell Biol. Int. Rep. 14, 133-141 (1990).

71 Alcaín, F.J., M.I. Burón, J.C. Rodríguez-Aguilera,J.M. Villalba and P. Navas: Ascorbate free radical stimulates the growth of a human promyelocandtic leukemia cell line". Cancer Res. 50, 5887-5891 (1990).

72 Hidalgo, A., García-Herdugo, G., González-Reyes, J. A., Morré, D.J. and Navas P.: "Ascorbate free radical stimulates onion root growth by increasing cell elongation". Bot. Gaz. 152, 282-288 (1991).

73 Alcaín F. J., Burón M. I., Villalba J. M. and Navas P.: "Ascorbate is regenerated by HL-60 cells through the transplasmalemma redox systen". Biochim. Biophys. Acta 1073, 380-385 (1991).

74 González- Quevedo, M., Alcaín F.J., González-Reyes, J.A., Burón, M.I. and Navas P.: "Growth patterns of the HL-60 human promyelocandtic cell line stimulated by ascorbate free radical". Cancer J. 4, 262-266 (1991).

75 González-Reyes, J.A., O Döring, P. Navas, G. Obst and M Böttger: "The effect of ascorbate free radical on the energy state of the plasma membrane of onion root cells: alteration of k+ efflux by ascorbate." Biochim. Biophys. Acta 1098, 177-183 (1992).

76 Brightman, A.O., Navas P., Minnifield, N. M. and Morré, D.J.: "Pyrophosphate-induced acidification of transcisternal elements of rat liver Golgi apparatus". Biochim. Biophys. Acta 1104, 188-194 (1992)..

77 Navas P., Alcaín F. J., Burón M.I., Rodríguez-Aguilera, J.C., Villalba J.M., Morré D.M. and Morré D.J.: "Growth factor-stimulated transplasma membrane electron transport in HL-60 cells". FEBS Lett. 299, 223-226 (1992).

78 Alcaín F.J., Villalba, J. M., Löw H., Crane F.L. and Navas P.: "Ceruloplasmin stimulates NADH oxidation of pig liver plasma membrane". Biochem. Biophys. Res. Commun. 186, 951-955 (1992).

79 Navarro, F., Rodríguez-Aguilera J.C., Alcaín F.J., Burón M.I., and Navas P.: "Ascorbate potentiates serum-induced S phase entry of quiescent 3T3 cells. Protoplasma 169, 85-87 (1992).

80 Navas P., Villalba J.M., Rodríguez-Aguilera, J.C., Canalejo A. and Burón M.I.: " Clathrin interaction with NADH dehydrogenases of rat liver plasma membrane". En: "Molecular mechanisms of membrane traffic". Eds. D.J. Morré, K.E. Howell, and J.J.M. Bergeron. Springer Verlag, Heidelberg, pp. 329-330 (1993).

81 Villalba J.M., Burón M.I., Roldán J.M. and Navas P.: "Plasma membrane glycoproteins during amphibian epidermal development". Protoplasma 172, 136-144 (1993).

82 Villalba J.M., Roldán J.M. and Navas P.: "Flask cells and flask-shaped glandular cells of amphibian skin specifically produce fucose-rich glycoproteins". Histochemistry 99, 363-367 (1993).

83 Villalba J. M., Canalejo A., Rodríguez-Aguilera J.C., Burón M.I., Morré D.J. and Navas P.: "NADH-AFR and ferricandanide reductase activities represent different levels of plasma membrane electron transport". J. Bioenerg. Biomembr. 25, 411-417 (1993).

84 De Cabo, R.C., J.A. González-Reyes, and Navas P.: "The onset of cell proliferation is stimulated by ascorbate free radical in onion root primordia". Biol. Cell 77, 231-233 (1993).

85 Burón; M.I., Rodríguez-Aguilera, J.C., Alcaín, F.J. and Navas P.: "Transplasma membrane redox sandstem in HL-60 cells is modulated during TPA-induced differentation". Biochem. Biophys. Res. Commun. 192, 439-445 (1993).

86 Villalba, J.M., Canalejo, A., Burón, M.I., Córdoba, F., Navas, P.: "Thiol groups are involved in NADH-ascorbate free radical reductase activity of rat liver plasma membrane". Biochem. Biophys. Res. Commun. 192, 707-713 (1993).

87 Burón M.I., Rodríguez-Aguilera, J.C., González-Reyes, J.A., Villalba J.M., Alcaín, F.J., and Navas P.: "A quantitative ultrastructural and cytochemical study of TPA-.induced diffetentiation in HL-60 cells". Leuk. Res. 17, 863-872 (1993).

88 Navas, P. "Tráfico and bioenergética de membranas. Introducción". En: "Progresos en Biología Celular". Eds. Becerra,J., Perez-Fígares,J.M. and Fernandez-Llebrez, P. Universidad de Málaga, pp. 169-170 (1993).

89 Navas, P. "Bioenergética del aparato de Golgi del hepatocito de rata". En: "Progresos en Biología Celular". Eds. Becerra,J., Perez-Fígares,J.M. and Fernandez-Llebrez, P. Universidad de Málaga, pp. 183-186 (1993).

90 Rodríguez-Aguilera, J. C., Navarrro, F., Arroyo, A., Villalba,J.M. and Navas,P. "Transplasma membrane redox system of HL-60 cells is controlled by cAMP". J. Biol. Chem. 268, 26346-26349 (1993).

91 González-Reyes, J.A., A. Hidalgo, J.A. Caler, R. Palos and Navas P.: "Nutrient uptake changes in ascorbate free radical-stimulated onion roots". Plant Physiol. 104, 271-276 (1994).

92 Navas, P., Villalba, J.M. and Córdoba, F. "Ascorbate functions at the plasma membrane". Biochim. Biophys. Acta 1197, 1-13 (1994).

93 Villalba, J.M., Navarro, F., Roldán, J.M., González-Reyes, J.A. and Navas, P.: "Expression of carbohydrate residues in plasma membrane glycoproteins during the differentiation of amphibian epidermal cells". Protoplasma 178, 87-96 (1994).

94 Serrano, A., Villalba, J.M., González-Reyes, J.A., Navas, P. and Córdoba, F.: "Two distinct NAD(P)H-dependent redox enzymes isolated from onion root plasma membranes". Biochem. Mol. Biol. Int. 32, 841-849 (1994).

95 Serrano, A., Córdoba, F., González-Reyes, J.A., Navas, P. and Villalba, J.M. : "Purification and characterization of two distinct NAD(P)H-dehydrogenases from onion (Allium cepa L.) root plasma membrane". Plant Physiol. 106, 87-96 (1994).

96 González-Reyes, J.A., Alcaín, F.J., Caler, J.A., Serrano, A., Córdoba, F. and Navas, P.: "Relationship between apoplastic ascorbate regeneration and the stimulation of root growth in Allium cepa L." Plant Sci. 100, 23-29 (1994)

97 Crane, F.L. and Navas, P.: “Minireviews on ascorbate in membranes. Introduction”. J. Bioenerg. Biomembr. 26, 347 (1994).

98 Rodriguez-Aguilera, J.C. and Navas, P.: "Extracellular ascorbate stabilization: enzymatic or chemical process?". J. Bioenerg. Biomembr. 26, 379-384 (1994).

99 López-Lluch, G., Burón, M.I., Alcaín, F.J., Borrego, F., Quesada, J.M. and Navas, P.: "Effect of ascorbate and calcitriol on HL-60 promyelocandtic cell line proliferation and differentiation". En: Vitamin D: A pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications. Eds. Norman, A.W., Bouillon, R. and Thomasset, M. Walter de Gruandter, Berlin, pp. 455-456 (1994).

100 Lüthje, S., González-Reyes, J.A., Navas, P., Döring, O. and Böttger, M.: "Inhibition of maize (Zea maands L.) root plasma membrane-bound redox activities by coumarins". Z. Naturforsch. 49c, 447-452 (1994).

101 Morré, D.J., Navas P., Rodríguez-Aguilera, J.C., Morré D.M:, Villalba J.M. De Cabo, R. de and Lawrence, J.: "Cyclic AMP- plus ATP-dependent modulation of the NADH oxidase of porcine liver plasma membranes". Biochim. Biophys. Acta. 1224, 566-574 (1994).

102 Alcaín, F.J., Löw, H., Crane, F.L. and Navas, P.: "Iron chelators hydroxyurea and bathophenanthroline disulfonate inhibit DNA synthesis by different pathways". Biochem. Mol. Biol. Int. 34, 273-279 (1994).

103 López-Lluch, G., Burón, M.I., Alcaín, F.J., Rodríguez-Aguilera, J.C. and Navas, P.: "Plasma membrane redox system during HL-60 induced differentiation". Protoplasma 184, 163-167 (1995).

104 Navas, P. and Gómez-Díaz, C. :"Ascorbate free radical and its role in growth control". Protoplasma 184, 8-13 (1995).

105 Serrano, A., Córdoba, F., González-Reyes, J.A., Santos, C., Navas, P. and Villalba, J.M.: "NADH-specific dehydrogenase from onion root plasma membrane: purification and characterization". Protoplasma 184, 133-139 (1995).

106 Rodríguez-Aguilera, J.C., Navarro, F., Arroyo, A., Alcaín, F.J., Villalba, J.M. and Navas, P.: "Vitamin C stabilization as a consequence of the plasma membrane redox system". Protoplasma 184, 229-232 (1995).

107 González-Reyes, J.A., Alcaín, F.J., Caler, J.A., Serrano, A., Córdoba, F. and Navas, P.: "Stimulation of onion root elongation by ascorbate and ascorbate free radical in Allium cepa L." Protoplasma 184, 31-35 (1995).

108 Villalba J.M., Navarro, F., Córdoba, F., Serrano, A., Arroyo, A., Crane, F.L. and Navas, P.: "Coenzyme Q reductase from liver plasma membrane: purification and role in transplasma membrane electron transport". Proc. Natl. Acad. Sci. USA 92, 4887-4891 (1995).

109 Morré, D.J., Brightman, A.O., Hidalgo, A., and Navas, P.: "Selective inhibition of auxin-stimulated NADH oxidase activity and elongation growth of soybean hypocotyls by thiol reagents". Plant Physiol. 107, 1285-1291 (1995).

110 Santos-Ocaña, C., Navas, P., Crane, F.L. and Córdoba, F.: "Extracellular ascorbate stabilization by the yeast Saccharomyces cerevisiae". J. Bioenerg. Biomembr. 27, 597-603 (1995).

111 Navarro, F., Villalba, J.M., Crane, F.L., MacKellar, W.C. and Navas, P.: "A phospholipid-dependent NADH-Coenzyme Q reductase from liver plasma membrane". Biochem. Biophys. Res. Commun. 212, 138-143 (1995).

112 Córdoba, M.C., Serrano, A., Córdoba, F., González-Reyes, J.A., Navas, P., and Villalba, J.M.: "Topography of the 27 and 31 kDa electron transport proteins in the onion root plasma membrane". Biochem. Biophys. Res. Commun. 216, 1054-1059 (1995).

113 Cabo, R.C. de, González-Reyes, J.A., Córdoba, F.and Navas, P.: "Rooting hastened in onions by ascorbate and ascorbate free radical". J. Plant Growth Reg. 15, 53-56 (1996).

114 Villalba, J.M., Córdoba, F. and Navas, P.: "Ascorbate and the plasma membrane: A new view of cell growth control". En: Subcellular Biochemistry. Ascorbic acid: Biochemistry and Biomedical Cell Biology, Harris,J.R. Ed. Plenum Press, New York, vol. 25, pp. 57-81 (1996).

115 Quesada, J.M., López-Lluch, G., Burón, M.I., Alcaín, F.J., Borrego, F., Velde, J.P., Blanco, I., Bouillon, R., and Navas, P.: "Ascorbate increases the 1,25 dihydroxyvitamin D3-induced monocytic differentiation of HL-60 cells". Calcified Tissue Int. 59, 277-282 (1996)

116 Córdoba-Pedregosa, M.C., González-Reyes, J.A., Cañadillas, M.S., Navas, P. and Córdoba, F.: “Role of apoplastic and cell-wall peroxidases on the stimulation of root elongation by ascorbate”. Plant Physiol. 112, 1119-1125 (1996).

117 Córdoba, F., Navas, P. and González-Reyes, J.A.: “El ácido ascórbico en las plantas: regulación del crecimiento and protección contra contaminantes ambientales”. Bol. Educ. Bioq. (México) 15, 182-168 (1996).

118 Villalba, J.M., Gómez-Díaz, C., Navarro, F. and Navas, P.: “Role of transplasma membrane redox system in cell protection against oxidative stress”. Trends Comp. Biochem. Physiol. 2, 65-71 (1996).

119 Morré, D.J., Rodríguez-Aguilera, J.C., Navas, P. and Morré, D.M.: "Redox modulation of the response of NADH oxidase activity of rat liver plasma membrane to cyclic AMP plus ATP ". Mol. Cell. Biochem. 173, 71-77 (1997).

120 Crane, F.L. and Navas, P.: “The diversity of coenzyme Q function”. Molec. Aspects Med. 18, S1-S6 (1997).

121 Villalba, J.M., Navarro, F., Gómez-Díaz, C., Arroyo, A., Bello, R.I. and Navas, P.: “Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane”. Molec. Aspects Med. 18, S7-S13 (1997).

122 Gómez-Díaz, C., Rodríguez-Aguilera, J.C., Barroso, M.P., Villalba, J.M., Navarro, F., Crane, F.L. and Navas, P.: "Antioxidant ascorbate is stabilized by NADH-coenzyme Q10 reductase in plasma membrane". J. Bioenerg. Biomembr. 269, 253-259 (1997).

123 Muñoz, E., Blázquez, M.V., Ortiz, C., Gómez-Díaz, C. and Navas, P.: “Role of ascorbate in the activation of NF-kB by tumor necrosis factor ? in T cells”. Biochem. J. 325, 23-28 (1997).

124 Gómez-Díaz, C., Villalba, J.M., Pérez-Vicente, R., Crane, F.L. and Navas, P.: “Ascorbate stabilization is stimulated in ??HL-60 cells by CoQ10 increase at the plasma membrane”. Biochem. Biophys. Res. Commun. 234, 78-81 (1997).

125 Barroso, M.P., Gómez-Díaz, C., Villalba, J.M., Burón, M.I., López-Lluch, G. and Navas, P.: “Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal”. J. Bioenerg. Biomembr. 29, 261-269 (1997).

126 Barroso, M.P., Gómez-Díaz, C., López-Lluch, G., Malagón, M.M., Crane, F.L. and Navas, P.: “Ascorbate and ?-tocopherol prevent apoptosis induced by serum removal independent of Bcl-2”. Arch. Biochem. Biophys. 343, 243-248 (1997).

127 López-Lluch, G., Burón, M.I., Alcaín, F.J., Quesada, J.M. and Navas, P.: "Ascorbate increases the effect of calcitriol on leukemic cells differentiation through the cAMP pathway". En: Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone. Eds. Norman, A.W., Bouillon, R. and Thomasset, M. Walter de Gruandter, Berlin, pp. 425-427  (1997).

128 López-Lluch, G., Quesada, J.M. and Navas, P.:”Papel del sistema endocrino de la vitamina D en los procesos de diferenciación”. En: 25 Hidroxivitamina D and Osteoporosis”. Ed. Quesada, J.M. Edika Med, SL, Barcelona, pp. 168-178  (1998).


129 Macho, A., Blázquez, M.-Valle, Navas, P. and Muñoz, E.: “Induction of apoptosis band vanilloid compounds is independent of JUN kinase and AP-1”. Cell Growth Diff. 9, 277-286 (1998)

130 López-Lluch, G., Burón, M.I., Alcaín, F.J., Quesada, J.M. and Navas, P.:”Redox regulation of 1?,25-dihidroxyvitamin D3-induced differentiation of HL-60 cells by ascorbate”.Biochem. J. 331, 21-27 (1998).

131 Santos-Ocaña, C., Córdoba, F., Crane, F.L., Clarke, C.F. and Navas, P.: “Role of coenzyme Q6 in the extracellular ascorbate stabilization at the plasma membrane of Saccharomyces cerevisiae”. J. Biol. Chem. 273, 8099-8105 (1998)

132 Kagan, V.E., Arroyo, A., Tyurin, V.A., Tyurina, Y.Y., Villalba, J.M. and Navas, P.: “Plasma membrane NADH-coenzyme Qo reductase generates semiquinone radicals and recycles vitamin E homologue in a superoxide-dependent reaction”. FEBS Lett. 428, 43-46 (1998).

133 Villalba, J.M., Navas, P. and Crane, F.L.: “Antioxidative role of ubiquinone in animal plasma membranes”. In: Plasma membrane redox systems and their role in biological stress and disease. Eds. Asard, H., Berczi, A., Caubergs, R. Kluwer, Berlin. pp. 247-265 (1998).

134 González-Reyes, J.A. and Navas, P.: “Involvement of plasma membrane redox systems in growth control of animal and plant cells”. En: Plasma membrane redox systems and their role in biological stress and disease. Eds. Asard, H., Berczi, A., Caubergs, R. Kluwer, Berlin. pp. 193-213 (1998).

135 Navarro, F., Navas, P., Burgess, J.R., Bello, R.I., Cabo, R. de, and Villalba, J.M. : “Vitamin E and selenium deficiency induces the expression of plasma membrane antioxidants”. FASEB J. 12, 1665-1673 (1998)

136 Santos-Ocaña, C., Villalba, J.M., Córdoba, F., Padilla, S., Crane, F.L., Clarke, C.F. and Navas, P.: “Genetic evidence for coenzyme Q requirement in plasma membrane electron transport”. J. Bioenerg. Biomembr. 30, 465-475 (1998)

137 Córdoba-Pedregosa, M.C., González-Reyes, J.A., Serrano, A., Villalba, J.M., Navas, P. and Córdoba, F.: "Plasmalemma-associated malate dehydrogenase activity in onion root cells". Protoplasma 205, 29-36 (1998).

138 Arroyo, A., Navarro, F., Navas, P. and Villalba, J.M.: "Ubiquinol regeneration by plasma membrane ubiquinone reductase". Protoplasma 205, 107-113. (1998).

139 Macho, A., Calzado, M.A., Gómez-Diaz, C., Gajate, C., Mollinedo, F., Navas, P. and Muñoz, E.: “Selective induction  of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium”. Cell Death Diff. 6, 155-165 (1999)

140 López-Lluch, G., Barroso, M.P., Martín, S., Fernández-Aandala, D.M., Gómez-Díaz, C., Villalba, J.M. and Navas, P.: "Role of plasma membrane coenzyme Q on the regulation of apoptosis". BioFactors 9, 171-177 (1999)

141 Navarro, F., Arroyo, A., Martín, S.F., Bello, R.I., Cabo, R. De, Burgess, J.R., Navas, P. and Villalba, J.M.:"Protective role of ubiquinone against oxidative stress caused by vitamin E and selenium deficiency". BioFactors 9, 163-170 (1999).

142 Siendones, E., González-Reyes, J.A., Santos-Ocaña, C., Navas, P. and Córdoba, F.: Biosynthesis of ascorbic acid in kidney bean. L-Galactono-?-lactone dehydrogenase is an intrinsic protein located at the mitochondrial inner membrane”. Plant Physiol. 120, 907-912 (1999).

143 Rodríguez-Aguilera, J.C., López-Lluch, G., Santos-Ocaña, C., Villalba, J.M., Gómez-Díaz, C. and Navas, P.: “Plasma membrane redox system protect cells against oxidative stress”. Redox Report 5, 2-4 (2000).

144 Villalba, J.M., López-Lluch, G., Santos-Ocaña, C., Rodríguez-Aguilera, J.C., and Navas, P.: “Extramitochondrial functions of coenzyme Q”. En: Coenzyme Q: Molecular Mechanisms in Health and Disease. V.E. Kagan and P.J. Quinn Eds. Pp. 83-98. CRC Press, Boca Ratón (2000).

145 Villalba, J.M. and Navas, P. “Plasma membrane redox system in the control of stress-induced apoptosis”. Antiox. Redox Signal. 2, 213-230 (2000).

146 Arroyo, A., Kagan, V.E., Tyurin, V.A., Burgess, J.R., Cabo, R, de, Navas, P. and Villalba, J.M.: “NADH and NADPH-dependent reduction of coenzyme Q at the plasma membrane”. Antiox. Redox Signal. 2, 251-262 (2000).

147 Fernández-Ayala, D.J.M., Martín, S.F., Barroso, M.P., Gómez-Díaz, C., Villalba, J.M., Rodríguez-Aguilera, J.C., López-Lluch, G., and Navas, P.:”Coenzyme Q protects cells against serum withdrawal-induced apoptosis by inhibition of ceramide release and caspase-3 activation”. Antiox. Redox Signal. 2, 263-275 (2000).

148 Arroyo, A., Navarro, F., Gómez-Díaz, C., Crane, F.L., Alcaín, F.J., Navas, P., and Villalba, J.M.: “Interactions between ascorbyl free radical and coenzyme Q at the plasma membrane”. J. Bioenerg. Biomembr. 30, 465-475 (2000).

149 Gómez-Díaz, C., Barroso, M.P. and Navas, P.: “Plasma membrane CoQ and growth control”. Protoplasma 214, 19-23 (2000).
150 Villalba J.M., Arroyo A., Navarro F., Rodríguez-Aguilera, J.C. and Navas, P. (2001) Insights in cellular protection against oxidative stress: The necessity for extramitochondrial coenzyme Q. In Mitochondrial Ubiquinone (Coenzyme Q10): Biochemical, Functional, Medical, and Therapeutic Aspects in Human Health and Diseases. Vol 2. M. Ebadi, J. Marwah, J. and R.K. Chopra, eds. (Prominent Press, Scottsdale, AZ) pp. 89-120.

151 López-Lluch, G., Blazquez, M-V., Pérez-Vicente, R., Macho, A., Burón, M.I. Alcaín, F.J. Muñoz, E. and Navas, P.: “Cellular redox state and AP-1 are involved in ascorbate effect on calcitriol-induced differentiation”. Protoplasma 217, 129-136 (2001).

152 Martín, S.F., Navarro, F., Forthoffer, N., Navas, P. and Villalba, J.M.:”Neutral Magnesium-dependent sphingomyelinase from liver plasma membrane: Purificación and inhibition by ubiquinol”. J. Bioenerg. Biomembr. 33, 143-153 (2001).

153 Navas, P., Fernández-Ayala. D.M., Martín, S.F., López-Lluch, G., de Cabo, R., Rodríguez-Aguilera, J.C. and Villalba, J.M.: "Biochemical Mechanisms of Plasma Membrane Coenzyme Q-dependent Cell Survival”. Free Rad. Res. 36, 369-374 (2002).

154 Santos Ocaña, C., Do, T.Q., Padilla, S., Navas, P. and Clarke, C.F.: “Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants”. J. Biol. Chem. 277, 10973-10981 (2002).

155. Forthoffer, N., Gómez-Díaz, C., Bello, R.I., Burón, M.I., Martín, S.F., Rodríguez-Aguilera, J.C., Navas, P. and Villalba, J.M.: "A novel plasma membrane quinone reductase and NAD(P)H:quinone oxidoreductase 1 are upregulated by serum withdrawal in human promyelocytic HL-60 cells". J. Bioenerg. Biomembr. 34, 209-219 (2002).

156. Martín, S.F., Gómez-Díaz, C., Navas, P. and Villalba, J.M.: "Ubiquinol inhibition of neutral sphingomyelinase in liver plasma membrane: specific inhibition of the Mg2+-dependent enzyme and role of isoprenoid chain". Bioichem. Biophys. Res. Commun. 297, 581-586 (2002).

157. Martín, S.F., Gómez-Díaz, C., Bello, R.I., Navas, P. and Villalba, J.M.: "Inhibition of Mg2+-dependent sphingomyelinase by ubiquinol-mediated plasma membrane electrón transport”. Protoplasma 221, 109-116 (2003).

158. Gómez-Díaz, C., Burón, M.I., Alcaín, F.J., González-Ojeda, R., González-Reyes, J.A., Bello, R.I., Herman, M.D., Navas, P. and Villalba, J.M.:” Effect of dietary coenzyme Q and fatty acids on the antioxidant status of rat tisúes”. Protoplasma 221, 11-17 (2003).

159. Asencio, C., Rodríguez-Aguilera, J.C., Ruiz-Ferrer, M., Vela, J. and Navas, P.:”Silencing of ubiquinone genes extends life span in Caenorhabditis elegans”. FASEB J. 17, 1135-1137 (10.1096/fj.02-1022fje) (2003).

160. Bello, R.I., Alcaín, F.J., Gómez-Díaz, C., López-Lluch, G., Navas, P. and Villalba, J.M. “Hydrogen peroxide and cell density-regulated expresión of cytochrome b5 reductase in HeLa cells”. J. Bioenerg. Biomembr. 35, 169-179 (2003).

161. Sánchez-Alcázar, J.A., Schneider, E., Hernández, I., Siles-Rivas, E., De la Torre, P., Borstein, B., Brea, G., Arenas, J., Garesse, R., Solís-Herruza, J.A., Knox, A. and Navas, P.: "Reactive oxigen species mediate the down-regulation of ATPase subunit a by Tumor Necrosis Factor-? in L929 cells". Biochem. J. 370, 609-619 (2003).

162. Navas, P. and Villalba, J. M.:” Regulation of ceramide signaling by plasma membrane Coenzyme Q reductases”. Meth. Enzymol. 378, 200-206 (2003)

163. Arroyo, A., Rodríguez-Aguilera, J.C., Santos Ocaña, C., Villalba, J. M. and Navas, P.: “Stabilization of extracellular ascorbate mediated by coenzyme Q transmembrane electrón transport”. Meth. Enzymol. 378, 207-217 (2003)
164. Bello, R.I., Gómez-Díaz, C., Navas, P. and Villalba, J.M. “NAD(P)H:quinone oxidoreductase 1 expression, hydrogen peroxide levels and growth phase in HeLa cells”. Meth. Enzymol. 382, 234-243 (2003).

165. Sánchez-Alcázar, J.A., Bradbury, D.A., Brea, G., Navas, P. and Knox, A.:”Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression”. Apoptosis 8, 639-647 (2003).

166 Rodríguez-Aguilera, J.C., Asencio, C., Ruiz-Ferrer, M., Vela, J. and Navas, P.:” Caenorhabditis elegans ubiquinone biosynthesis genes”. Biofactors 18, 237-244 (2003).

167. Gómez-Díaz, C., Bello, R.I., López-Lluch, G., Forthoffer, N., Navas, P.  and Villalba, J.M. “Antioxidant response induced by serum withdrawal protects HL-60 cells against inhibition of NAD(P)H:quinone oxidoreductase 1”. Biofactors 18, 219-228 (2003).

168. Bello, R.I., Gómez-Díaz, Navas, P. and Villalba, J.M. NAD(P)H:quinone oxidoreductase 1 expression, hydrogen peroxide levels and growth phase in HeLa cells Meth. Enzymol.  382, 234    243 (2004).

169. Navas, P. and Villalba, J.M. Regulación of ceramide signaling by plasma membrane Coenzyme Q reductases. Meth. Enzymol.  378, 200- 206 (2004).

170. Arroyo, A., Rodríguez-Aguilera, J.C., Santos Ocaña, C., Villalba, J. M. and Navas, P. Stabilization of extracellular ascorbate mediated by coenzyme Q transmembrane electrón transport. Meth. Enzymol. 378, 207-217 (2004)

171. Cabo, R. de, Cabello, R., Rios, M., López-Lluch, G., Ingram, DK., Lane, MA. and Navas, P. The plasma membrane antioxidant system of liver is increased in aging rats by calorie restriction. Exp. Gerontol. 39, 297- 304 (2004).

172. Padilla, S., Jonassen, T., Jimenez-Hidalgo, M., Moreno, D.J., Lopez-Lluch, G., Navas, P., Clarke, C.F. and Santos-Ocaña, C. Demethoxy-Q, an Intermediate of Coenzyme Q Biosynthesis, Fails to Support Respiration in Saccharomyces cerevisiae and Lacks Antioxidant Activity. J. Biol. Chem. 279, 25995 – 26004 (2004)

173. Fernandez-Ayala, D.J.M., López-Lluch, G.,  García-Valdés, M., Arroyo, A. and Navas, P. Specificity of coenzyme Q10 for a balanced function of respiratory chaín and endogenous ubiquinone biosíntesis in human cells. Biochim. Biophys. Acta.-Bioenergetics 1706, 174 – 183 (2005)

174. Rodríguez-Aguilera, J.C., Gavilán, A., Asencio, C. and Navas, P. The role of ubiquinone in Caenorhabditis elegans longevity. Aging Res. Rev. 4, 41- 53 (2005)

175. López-Lluch, G., Fernandez-Ayala, D.J.M., Alcaín, F.J., Burón, M.I., Quesada, J.M. and Navas, P. Inhibition of COX activity by NSAIDs or ascorbate increases cAMP levels and enhances differentiation in 1a,25-dihydroxyvitamin D3-induced HL-60 cells. Arch. Biochem. Biophys. 436, 32 – 39 (2005)

176. Bello, R.I., Gómez-Díaz, C., López-Lluch, G., Forthoffer, N., Córdoba-Pedregosa, M.C., Navas, P. and Villalba, J.M. Dicoumarol relieves serum withdrawal-induced G0/1 blockade in HL-60 cells through a superoxide-dependent mechanism. Biochem. Pharmacol. 69, 1613 – 1625 (2005)

177. Fernandez-Ayala, D.J.M., Brea-Calvo, G., López-Lluch, G., and Navas, P. Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system. Biochim. Biophys. Acta.-Biomembranes 1713, 129 - 137 (2005)

178. Artuch, R., Pineda, M., Vilaseca, M.A., Sánchez-Alcázar, J.A. and Navas, P. Coenzyme Q10 deficiency and mitochondrial encephalomyopathies: clinical, biochemical and molecular diagnsis. Ubiquinone-10 supplementation. New Frontiers in Mitochondrial Biogenesis and Disease, pp. 93-110 (2005) (Ed. F. Villarroya)

179. Salviati, L; Sacconi, S; Murer, L; Zacchello, G; Franceschini; L; Laverda, A.M.; Basso, G.; Quinzii; C; Angelini, C.; Hirano, M.; Naini, A. B.; Navas, P.; DiMauro, S.  and Montini, G. Infantile Encephalomyopathy and Nephropathy with CoQ10 deficiency: a CoQ10-responsive Condition. Neurology 65, 606 - 608 (2005)

180. Navas, P., Villalba, J.M.  and Lenaz, G. Coenzyme Q-dependent functions of plasma membrane in aging process. AGE 27, 139 – 146 (2005)

181. López-Lluch, G., Rios, G., Lane, M.A., Navas, P., and de Cabo, R. Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction. AGE 27, 153 – 160 (2005)

182. Rodríguez-Hernández, A., Brea-Calvo, G.,  Fernández-Ayala, D.J.M., Cordero, M., Navas, P. and Sánchez-Alcázar, J.A. Nuclear caspase-3 and caspase-7 activation, and Poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis. Apoptosis 11, 131-139 (2005)

183. Bello, R.I., Gómez-Díaz, C., Burón, M.I., Alcaín, F.J., Navas, P. and Villalba, J.M. Enhanced antioxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp. Gerontol. 40, 694 – 704 (2005)

184. González-Aragón, D., Burón, M. I, López-Lluch, G. Hermán, M. D., Gómez-Díaz, C., Navas, P. and Villalba, J. M. Coenzyme Q and the regulation of intracellular steady state levels of superoxide in HL-60 cells. Biofactors 25, 31 – 41 (2005)

185. Gavilán, A., Asencio, C., Cabello, J., Rodríguez-Aguilera, J. C., Schnabel, R., Navas, P. C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development. Biofactors 25, 21 – 29 (2005)

186. Brea-Calvo, G.; Rodriguez-Hernandez, A.; Fernandez-Ayala, D.J.M.; Navas, P. and  Sanchez Alcazar, J.A. Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines. Free Rad. Biol. Med. 40, 1293 – 1302 (2006)

187. Asencio, C. Rodríguez-Aguilera, J.C., Vázquez, R., Baylis, H., Cabello, J., Schnabel, R., Gavilán, A., and Navas, P. Differential expression pattern of COQ8 gene during development in Caenorhabditis elegans. Gene Exp Patt (Mech Dev). 6, 433 – 439 (2006)

188. Quinzii, C;  Naini, A. ; Salviati, L. ; Trevisson, E. ; Navas, P. ; DiMauro, S. and Hirano, M. A mutation in 4-para-hydroxybenzoate:polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. Am J Human Genetics 78, 345 – 349 (2006)

189. Naini, A. ; Salviati, L. ; Trevisson, E. ; Navas, P. ; DiMauro, S., Hirano, M. and Quinzii, C. Genetics of primary coenzyme Q10 deficiency. Current Genomics 7, 345 – 349 (2006)

190. Miranda-Vizuete A, Gonzalez JC, Gahmon G, Burghoorn J, Navas P, and Swoboda P. Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons. FEBS Lett  580, 484 – 490 (2006)

191. López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S.,Cascajo, M.V., Allard, J., Ingram, D.K., Navas, P. and De Cabo, R. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. USA     103, 1768 – 1773 (2006)

192. Arroyo, A., Santos-Ocaña, C., Ruiz-Ferrer, M., Padilla, S., Gavilán, A., Rodríguez-Aguilera, J. C., Navas, P. Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans. FEBS Lett 580, 1740 – 1746 (2006)

193. Artuch, R., Brea-Calvo, G., Briones, P., Aracil, A., Galván, M., Espinós, C., Corral, J., Volponi, V., Ribes, A., Andreu, A.L:, Palau, F., Sánchez-Alcázar, J.A., Navas, P.  and Pineda, M. Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation. J. Neurol. Sci. 246, 153 – 158 (2006)

194. Montero R, Artuch R, Briones P, Nascimento A, Garcia-Cazorla A, Vilaseca MA, S Nchez-Alc Zar JA, Navas P, Montoya J, Pineda M. Muscle coenzyme Q10 concentrations in patients with probable and definite diagnosis of respiratory chain disorders. Biofactors 25, 109 – 115 (2005)

195. DE Cabo, R., Burgess, J.R., and Navas, P. Adaptations to oxidative stress induced by vitamin E deficiency in rat liver. J. Bioenerg. Biomembr. 38, 309 – 317 (2006)

196. Bello, R.I., Gómez-Díaz, C., Burón, M.I., Alcaín, F.J., Navas, P. and Villalba, J.M. Differential regulation of hepatic apoptotic pathways by dietary olive and sunflower oils in the aging rat. Exp. Gerontol. 41, 1174 – 1184 (2006)

197.  Baur, J.A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., Pistell, P., Poosala, S., Becker, K. G., Boss, O., Gwinn, D., Le Couteur, D., Shaw, R. J., Navas, P., Puigserver, P., Ingram, D. K., de Cabo, R. and Sinclair, D. A. Resveratrol mimics a low calorie diet and extends lifespan in mice. Nature 444, 337- 342 (2006)

198. Navas, P., Villalba, JM., and de Cabo, R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 7S, 34–40 (2007)

199. Sanchez Alcazar, J.A., Rodriguez-Hernandez, A.; Cordero, M.; Fernandez-Ayala, D.J.M.; Brea-Calvo, G.; García, K.; and Navas, P. Apoptotic Microtubule Network preserves plasma membrane permeability in the execution phase of apoptosis. Apoptosis 12, 1195–1208 (2007)

200. López-Martín, J.M., Salviati, L., DiMauro, S., Hirano, M., Rodriguez-Hernandez, A.; Cordero, M.; Sanchez Alcazar, J.A., Santos-Ocaña; C. and Navas, P. Loss of function of COQ2 gene product promotes pathogenicity in infantile encephalomyopathy with nephropathy. Human Mol. Genetics 6, 109 –1097 (2007)

201. Montero R, Pineda M, Vilaseca MA, Briones P, Sánchez-Alcázar JA, Navas P, Artuch R. Clinical, biochemical and molecular aspects of cerebellar ataxia and coenzyme Q10 deficiency. Cerebellum 6, 118-122 (2007)

202. Santos-Gozález, M., Gómez-Díaz, C., Navas, P. and Villalba, J.M. Modifications of plasma proteome in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp. Gerontol. 42, 798-806 (2007)

203. Siendones E, Brea-Calvo G, Cascajo-Almenara MV, López-Lluch G, Sánchez-Alcázar JA, Navas P. The two faces of a same function: pro- and antiapoptotic role of ubiquinone. Frontiers in cell apoptosis research. Scott R. Erlich (editor). ISBN 10: 1-60021-450-9, pp. 1 – 36 (2007) Nova Science Publishers, Inc. New York

204. Moreno-Fernández AM, Cordero MD, de Miguel M, Delgado-Rufino MD, Sánchez-Alcázar JA, Navas P. Cytotoxic effects of amitriptyline in human fibroblasts. Toxicology 243, 51-58 (2008)

205. Pearson, KJ., Lewis, KN, Price, NL, Chang, JW, Perez, E, Cascajo,MV, Tamashiro, KL, Poosala2, S., Bell, J.B., Kensler, TW, Yamamoto, M., Egan, JM., Longo, DL., Ingram, D.K., Navas, P., and de Cabo, R. Nrf2 Mediates Cancer Protection but not Prolongevity induced by Caloric Restriction. Proc. Natl. Acad. Sci. USA. 105, 2325–2330 (2008)

206. A Casarin, J C Jimenez-Ortega, E Trevisson, V Pertegato, M Doimo, M L Ferrero-Gomez, S Abbadi, R Artuch, C Quinzii, M Hirano, G Basso, C Santos Ocaña, P Navas, and L Salviati. Functional characterization of human COQ4, a gene required for Coenzyme Q10 biosynthesis. Biochem Biophys Res Commun 372, 35–39 (2008)

207. Quinzii, C., López, L. C.; Von-Moltke, J.; Naini, A.; Krishna, S.; Schuelke, M.; Salviati, L.; Navas, P.; DiMauro, S. and Hirano, M. Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency. FASEB J
22, 1874 -1885    (2008)

208. Hernandez, A.; López-Lluch, G.; Bernal, J. A.; Navas, P. and Pintor-Toro, J. A. Dicoumarol downregulates human PTTG1/Securin mRNA expression through inhibition of Hsp90. Mol Cancer Therapeutics 7, 474 – 482 (2008)

209. Montero R, Sáchez-Alcázar JA, Briones P, Rodríguez-Hernández, MA, Cordero, MD, Trevisson, E, Salviati, L, Pineda M, Garcia-Cazorla A, Navas P, and Artuch R. Analysis of Coenzyme Q10 in muscle and fibroblasts for the diagnosis of CoQ10 deficiency syndromes. Clin Biochem 41, 697 - 700 (2008)

210. Pearson, K.J. *, Baur, J.A., Lewis, K.N., Price, N.L., Minor, R., Perez, E., Kamara, D., Jamieson, H.A., Zhang, Y., Peshkin, L., Dunn S., Sharma, K., Pleshko, N., Woollett, L., Labinskyy, N., Csiszar, A., Ikeno, Y., Le Couteur, D., Becker, K.G., Navas, P., Ingram, D.K., Wolf, N., Ungvari, Z., Sinclair, D.A., and de Cabo, R. Resveratrol mimics aspects of dietary restriction and delays diseases of aging in mice. Cell Metabolism. 8, 157 - 168 (2008)

211. Fontán-Lozano, A., López-Lluch, G., Delgado-García, JM., Navas, P., and Carrión, AM. Molecular bases of caloric restriction regulation of neuronal synaptic plasticity. Molecular Neurology 38, 167 – 177 (2008)

212. López-Lluch G, Irusta, P.M., Navas, P. and de Cabo, R. Mitochondrial biogenesis and healthy aging. Exp Gerontol 43, 813 – 819 (2008)

213. Ortiz T, Burguillos MA, López-Lluch G, Navas P, Herrador M, González I, Piñero J. Enhanced induction of apoptosis in a radio-resistant bladder tumor cell line by combined treatments with X-rays and wortmannin. Radiat Environ Biophys. 47, 445 - 452 (2008)

214. Padilla, S., Santos-Ocaña, J. C., Jiménez-Hidalgo, M., López-Martín, J.M., Martín-Montalvo, A. and Navas, P. Demethoxy-Q6 functions as a control molecule for coenzyme Q6 biosynthesis in Saccharomyces cerevisiae and defines a biosynthesis complex independent on Coq7 protein. Cell Mol Life Sci 66, 173 – 186 (2009)

215. Asencio, C. Rodríguez-Aguilera, Johnson, T.E., J.C., Cabello, J., Schnabel, R., and Navas, P. COQ8 gene function is essential for fertility and lifespan establishment in Caenorhabditis elegans. Mech Aging Dev. 130, 145 -153 (2009)

216. Jiménez-Hidalgo, M.; Santos-Ocaña, C., Padilla, S., Villalba, JM, López-Lluch, G., Martín-Montalvo, A., Sinclair, DA., de Cabo, R., and Navas, P. NQR1 controls lifespan regulating the promotion of respiratory metabolism in yeast. Aging Cell 8, 140 -151 (2009)

217. Hernandez, A.; López-Lluch, J. A.; Navas, P.; and Pintor-Toro, J. A. HDAC and Hsp90 downregulate PTTG1/Securin but do not induce aneuploidy. Genes, Chromosome and Cancer 48, 194 - 201 (2009)

218. Montero R, Sáchez-Alcázar JA, Briones P,, Garesse, R.,Ruiz-Pesini, E., Montoya, J., Martí, M. R.,  Pineda M, Garcia-Cazorla A, Navas P, and Artuch R. Coenzyme Q10 deficiency associated with a mitochondrial DNA depletion syndrome. Clin Biochem 42, 742 – 745 (2009)

219. Padilla, S., Jiménez-Hidalgo, M., Martín-Montalvo, A., Santos-Ocaña, C. Navas, P. Genetic evidence for the requirement of the endocytic pathway in the Coenzyme Q6 intake in Saccharomyces cerevisiae. Biochim Biophys Acta 1788, 1238 – 1248 (2009)

220. Rodriguez-Hernandez, MA.; Cordero, MD.; Salviati, L.; Artuch, R.; Gómez-Izquierdo, L.; Cotán, D.; Navas, P. and Sanchez Alcazar, J.A. Coenzyme Q deficiency triggers selective degradation of mitochondria by mitophagy. Autophagy 5, 19 – 32 (2009)

221. Cordero MD, Moreno-Fernández AM, de Miguel M, Bonal, P., Campa, F., Jiménez-Jiménez, LM., Ruiz-Losada, A., Sánchez-Domínguez, B., Sánchez-Alcázar JA,  Salviati, L., and Navas P. Coenzyme Q distribution in blood is altered in patients with Fibromyalgia. Clin Biochem 42, 732 – 735 (2009)

222. de Cabo, R. and Navas, P. “AcCoA”lade for energy and life span. Cell Metabolism. 9, 305 - 306 (2009)

223. Brea-Calvo, G., Siendones, E., Sánchez-Alcázar, JA, de Cabo, R, and Navas, P. Cell survival from chemotherapy depends on NF-kB transcriptional up-regulation of coenzyme Q biosynthesis. PLoS ONE 4, e5301 (2009)

224. Trevisson E, Burlina A, Doimo M, Pertegato V, Casarin A, Cesaro L, Navas P, Basso G, Sartori G, and Salviati L. Functional complementation in yeast allows molecular characterization of missense argininosuccinate lyase mutations. J Biol Chem 284, 28926 – 28934 (2009)

225. González R, Ferrín G, Hidalgo AB, Ranchal I, López-Cillero P, Santos-Gónzalez M, López-Lluch G, Briceño J, Gómez MA, Poyato A, Villalba JM, Navas P, de la Mata M, and Muntané J. N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chem Biol Interact. 181, 95 – 106 (2009)

226. Artuch, R., Salviati, L., Jackson, S., Hirano, M., and Navas, P. Inherited Neuromuscular Diseases. C. Espinós et al. (eds.) Advances in Experimental Medicine and Biology 652. Springer DOI 10.1007/978-90-481-2813-6_8 (2009)

227. Cordero MD, Moreno-Fernández AM, Gomez-Skarmeta, JL, de Miguel M, Garrido-Maraver, J, Oropesa-Avila M, Rodriguez-Hernandez A, Navas P, and Sánchez-Alcázar J. A. Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity. Toxicol Appl Pharmacol. 235, 329 – 337 (2009)

228. P. Navas, I. Sun, F. L Crane, D. M. Morré and D. J. Morre. Monoascorbate free radical-dependent oxidation-reduction reactions of liver Golgi apparatus membranes. J Bioenerg Biomembr 42,  181–187 (2010)

229. López-Lluch, G., Rodríguez-Aguilera, JC., Santos-Ocaña, C., and Navas, P. Is Coenzyme Q a key factor in aging?. Mech Aging Dev. 131, 225–235 (2010)

230. Pineda M, Montero R, Aracil A, O'Callaghan MM, Mas A, Espinos C, Martinez-Rubio D, Palau F, Navas P, Briones P, and Artuch R. Coenzyme Q10-responsive ataxia: 2-year-treatment follow-up. Mov Disord. 25, 1262 - 1268 (2010)

231. Cordero MD, Moreno AM, Carmona MI, Sánchez-Alcázar JA, Rodríguez AF, Navas P, and de Miguel M. Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients. Clin Biochem. 43, 1174–1176 (2010)

232. Cordero MD, Miguel, M de., Moreno-Fernández AM, Carmona, IM,, Garrido-Maraver, J, Cotan, D., Gómez, L., Bonal, P, Campa, F, Bullón, P, Navas P, and Sánchez-Alcázar JA. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Arthritis Res Ther. 12, R17 (2010)

233. K. Hagopian, K.L. Weber, D. T. Hwee, A.L. Van Eenennaam, G. López-Lluch, J. M. Villalba, I. Burón, P. Navas, J. B. German, S. M. Watkins, Y. Chen, A. Wei, R. B. McDonald, and J. J. Ramsey. Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. Plos One  5, e12696 (2010)

234. S. Santa-Cruz Calvo, P. Navas, G. López-Lluch. Epigenetics in aging and age-related diseases. Approaches to aging control 14, 68 – 74 (2010)

235. Rodríguez-Bies, E., S. Santa Cruz-Calvo, A. Fontán-Lozano, J. Peña-Amaro, F.J. Berral de la Rosa, A.M. Carrión, P. Navas, G. And López-Lluch. Muscle physiology changes induced by every other day feeding and endurance exercise in mice: Effects on physical performance. Plos One 5, e13900 (2010)

236. Cordero, M.D., E. Alcocer-Gómez, FJ Cano-García, M De Miguel, AM Carrion, P Navas, JA Sánchez-Alcázar. Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma. PLoS ONE  6, e26915 (2011)

237. De Cabo, R., Siendones, E., Minor, R, Navas, P. CyB5R3: a key player in aerobic metabolism in aging? Aging (Albany, NY) 2:63-68 (2010)

238. Trevisson, E, S DiMauro, P Navas, and L Salviati. Coenzyme Q deficiency in muscle. Curr. Opin. Neurol 24, 449 – 456 (2011)

239. Martín-Montalvo, A , I González-Mariscal, S Padilla, M Ballesteros, DL Brautigan, P Navas, and C Santos-Ocaña. Respiratory-induced cooenzyma Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem. J 440, 107 – 114 (2011)

240. Cotán, D., MD Cordero, J Garrido-Maraver, M Oropesa-Ávila, A Rodríguez-Hernández, L Gómez-Izquierdo, M  De La Mata, M De Miguel, JB Lorite, ER Infante, S Jackson, P Navas, and JA Sánchez-Alcázar. Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts. FASEB J. 25, 2669 -2687 (2011)

241. Oropesa, M., de la Mata, M., Garrido-Maraver, J., Cordero, M.D.,Cotán, D., Rodríguez -Hernández, Á., Domínguez-Moñino, I., de Miguel, M., Navas, P., Sánchez-Alcázar. J. A. Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria. Apoptosis 16, 404 - 424 (2011)

242. Heeringa SF, Chernin G, Chaki M, Zhou W, Sloan AJ, Ji Z, Xie LX, Salviati L, Hurd TW, Vega-Warner V, Killen PD, Raphael Y, Ashraf S, Ovunc B, Schoeb DS, McLaughlin HM, Airik R, Vlangos CN, Gbadegesin R, Hinkes B, Saisawat P, Trevisson E, Doimo M, Casarin A, Pertegato V, Giorgi G, Prokisch H, Rötig A, Nürnberg G, Becker C, Wang S, Ozaltin F, Topaloglu R, Bakkaloglu A, Bakkaloglu SA, Müller D, Beissert A, Mir S, Berdeli A, Varpizen S, Zenker M, Matejas V, Santos-Ocaña C, Navas P, Kusakabe T, Kispert A, Akman S, Soliman NA, Krick S, Mundel P, Reiser J, Nürnberg P, Clarke CF, Wiggins RC, Faul C, and Hildebrandt F. COQ6 mutations in human patients produce nephritic syndrome with sensorineural deafness. J. Clin. Invest. 121, 2013 – 2024 (2011)

243. Bautista-Ferrufino MR, Cordero MD, Sánchez-Alcázar JA, Illanes M, Fernández-Rodríguez A, Navas P, and de Miguel M. Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver. Toxicol Lett 4, 32 – 37 (2011)

244. Santos-González M, López-Miranda J, Pérez-Jiménez F, Navas P, and Villalba JM. Dietary oil modifies the plasma proteome during aging in the rat. Age (Dordr.) 15, 1728 - 1736 (2011)

245. Lara Padilla, E., R. Campos-Rodríguez, A., Miliar, H. Reyna Garfias, V. Ribera Aguilar, R.A. Jarillo-Luna, F.J. Berral de la Rosa, P. Navas and G. López-Lluch. Caloric restriction reduces the levels of IgA and modified the expression of cytokines in the small intestine of mice. J. Nutr. Biochem 22, 560 – 566 (2011)

246. Parrado, C., G. López-Lluch, E. Rodríguez-Bies, S. Santa-Cruz, P. Navas, J.J. Ramsey, and J.M. Villalba. Calorie restriction modifies ubiquinone and COQ transcripts levels in mouse tissues. Free Rad. Biol. Med. 50, 1728 - 1736 (2011)

247. G. López-Lluch, and P. Navas. Pleitropic effects of physical exercise on healthy aging. Rev Andal Med Deporte 4, 77 - 83 (2011)

248. Martín-Montalvo, A., Villalba, J.M., Navas, P., and de Cabo, R. NRF2, cancer and calorie restriction. Oncogene 30, 505 - 520     (2011)

249. De Beas-Jiménez, J., G. López-Lluch, I. Sánchez-Martínez, A. Muro-Jiménez, E. Rodriguez-Bies, and P. Navas. Sarcopenia: implications of physical exercise in its pathophysiology, prevention and treatment. Rev Andal Med Deporte 4, 158 -166  (2011)

250. Cacho-Valadez, B., F. Muñoz-Lobato, J.R. Pedrajas, J.Cabello, JC Hierro-González, P. Navas, P. Swoboda, CD Link, and A. Miranda-Vizuete. The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers and unexpected protective role of TRXR-2 in ?-amyloid peptide toxicity. Antioxid Redox Signal. 16, 1384-400 (2012)

251. López-Lluch, G., S. Santa-Cruz Calvo, and P. Navas. Resveratrol in cancer: cellular and mitochondrial consequences of proton transport inhibition. Curr. Pharm. Des. 18,1338-1344 (2012)

252. Santa-Cruz Calvo, S., P. Navas, and G. López Lluch. Sirtuin-dependent metabolic control and its role in the aging process. Bioenergetics (Kevin B. Clark, ed, ISBN: 9*79-953-307-383-4) (2012)

253. Salviati, L., E. Trevisson, M.A. Rodríguez-Hernández, A. Casarin, V. Pertegato, M. Doimo, M. Cassina, C. Agosto, M.A. Desbats, G. Sartori, S. Sacconi, L. Memo, O. Zuffardi, R. Artuch, C. Quinzii, S. DiMauro, M. Hirano, C. Santos-Ocaña, and P. Navas. Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency, J. Med. Genet 49, 187-191 (2012)

254. Chen, Y., K. Hagopian, R.B., McDonald, D. Bibus, G. López-Lluch, J. M. Villalba, P. Navas, J.J. Ramsey. The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction. J. Gerontol-Biol Sci Med Sci 67, 1121-1131 (2012)

255. Garrido-Maraver J, Cordero MD, Moñino ID, Pereira-Arenas S, Lechuga-Vieco AV, Cotán D, De la Mata M, Oropesa-Ávila M, De Miguel M, Bautista Lorite J, Rivas Infante E, Alvarez-Dolado M, Navas P, Jackson S, Francisci S, Sánchez-Alcázar JA. Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease. Br J Pharmacol. 167:1311-1328 (2012)

256. Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K,McDonald RB, Ramsey JJ. The Influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction. Biosci Rep. 33:83-95 (2012)

257. Crane FL, Navas P, Low H, Sun IL, de Cabo R. Sirtuin Activation: A Role for Plasma Membrane in the Cell Growth Puzzle. J Gerontol A Biol Sci Med Sci. 68: 368-370 (2013)

258. López-Domínguez JA, Khraiwesh H, González-Reyes JA, López-Lluch G, Navas P, Ramsey JJ, de Cabo R, Burón MI, Villalba JM. Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice. Age (Dordr). 35:2027-2044 (2013)

259. Khraiwesh H, López-Domínguez JA, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, Villalba JM, González-Reyes JA. Alterations of Ultrastructural and Fission/Fusion Markers in Hepatocyte Mitochondria From Mice Following Calorie Restriction With Different Dietary Fats. J Gerontol A Biol Sci Med Sci. 68:1023-1034 (2013)

260. Serrano-Bueno G, Hernandez A, Lopez-Lluch G, Perez-Castineira JR, Navas P, Serrano A. Inorganic pyrophosphatase defects lead to cell cycle arrest and autophagic cell death through NAD+-depletion in fermenting yeast. J Biol Chem. 288:13082-13092 (2013)

261. Fernández-Ayala, D J M, IGuerra I, Jiménez-Gancedo S, Cascajo MV, Gavilán A, DiMauro S, Hirano M, Briones P, Artuch R, De Cabo R, Salviati L, Navas P. Survival transcriptome in the coenzyme Q10 deficiency syndrome is acquired by epigenetic modifications: a modelling study for human coenzyme Q10 deficiencies. BMJ Open 3:e002524, doi:10.1136/bmjopen-2012-002524 (2013)

262. Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo A, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA. Assembly of respiratory supercomplexes determines electron flux in the mitochondrial electron transport chain. Science 40:1567-1570 (2013)

263. Montero R, Grazina M, López-Gallardo E, Montoya J, Briones P, Navarro-Sastre A, Land JM, Hargreaves IP, Artuch R; O’Callaghan MM, Jou, C, Jimenez C, Buján N, Pineda M, García-Cazorla A, Nascimento A, Perez-Dueñas B, Ruiz-Pesini E, Fratter C, Salviati L, Simöes M, Mendes C, JoäoSantos M, Diogo L, Garcia P, Navas P. Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes. Mitochondrion 13:337-341 (2013).

264. Martín-Montalvo A, González-Mariscal I, Pomares T, Padilla S, Ballesteros M, Vazquez-Fonseca L, Gandolfo P, Brautigan DL, Navas P, Santos-Ocaña C. Ptc7 induces coenzyme Q biosynthesis by activating Coq7p dephosphorylation in yeast. J Biol Chem 288:28126-137 (2013).

265. Jiménez-Gómez Y, Mattison JA, Pearson KJ, Martin- Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R. Resveratrol improves adipose insulin sensitivity and inflammation in Rhesus monkeys on a high-fat, high-sugar diet. Cell Metab 18:533-545 (2013).

266. Tung BT, Rodríguez-Bies E, Ballesteros-Simarro M, Motilva V, Navas P,
López-Lluch G. Modulation of Endogenous Antioxidant Activity by Resveratrol and
Exercise in Mouse Liver Is Age Dependent. J Gerontol A Biol Sci Med Sci. 69:398-409 (2014)

267. Buján N, Arias A, Montero R, García-Villoria J, Lissens W, Seneca S, Espinós C, Navas P, De Meirleir L, Artuch R, Briones P, Ribes A. Characterization of CoQ(10) biosynthesis in fibroblasts of patients with primary and secondary CoQ(10) deficiency. J Inherit Metab Dis. 37:53-62 (2014)

268. Del Pozo-Cruz J, Rodríguez-Bies E, Navas-Enamorado I, Del Pozo-Cruz B, Navas P, López-Lluch G. Relationship between functional capacity and body mass index with plasma coenzyme Q10 and oxidative damage in community-dwelling elderly-people. Exp Gerontol. 52:46-54 (2014)

269. Doimo M, Trevisson E, Airik R, Bergdoll M, Santos-Ocaña C, Hildebrandt F, Navas P, Pierrel F, Salviati L. Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Biochim Biophys Acta. 1842:1-6 (2014)

270. Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K, Ramsey JJ. The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction. Physiol Res. 63:57-71 (2014)

271. Del Pozo-Cruz J, Rodríguez-Bies E, Ballesteros-Simarro M, Navas-Enamorado I, Tung BT, Navas P, López-Lluch G. Physical activity affects plasma coenzyme Q10 levels differently in young and old humans. Biogerontology 15:199-211 (2014)

272. Siendones E, Martín-Montalvo A, Santa-Cruz S, Cascajo MV, Ariza J, López-Lluch G, Villalba JM, Acquaviva-Bourdain C, Roze E, de Cabo R, Navas P. Membrane-bound CYB5R3 is the common effector of nutritional and oxidative stresses response through FOXO3a and Nrf2. Antioxid Redox Signal 21:1708-1725 (2014)

273. Rodríguez-Bies E, Navas P, López-Lluch G. Age-Dependent Effect of Every-Other-Day Feeding and Aerobic Exercise in Ubiquinone Levels and Related Antioxidant Activities in Mice Muscle. J Gerontol A Biol Sci Med Sci. (2014)  PubMed PMID: 24496576

274. López-Domínguez JA, Khraiwesh H, González-Reyes JA, López-Lluch G, Navas P, Ramsey JJ, de Cabo R, Burón MI, Villalba JM. Dietary Fat and Aging Modulate Apoptotic Signaling in Liver of Calorie-Restricted Mice. J Gerontol A Biol Sci Med Sci. (2014) PubMed PMID: 24691092

275. Khraiwesh H, López-Domínguez JA, Del Río LF, Gutierrez-Casado E, López-Lluch G, Navas P, de Cabo R, Ramsey JJ, Burón MI, Villalba JM, González-Reyes JA. Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats. Exp Gerontol. 56:77-88 (2014).

276. Nguyen TP, Casarin A, Desbats MA, Doimo M, Trevisson E, Santos-Ocaña C, Navas P, Clarke CF, Salviati L. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. Biochim Biophys Acta. 1841:1628-1638 (2014).

277 Crane FL, Löw H, Sun I, Navas P, Gvozdjáková A. Plasma membrane coenzyme Q: evidence for a role in autism. Biologics 8:199-205 (2014).

278 Fernández-Ayala DJ, Jiménez-Gancedo S, Guerra I, Navas P. Invertebrate models for coenzyme Q10 deficiency. Mol Syndromol. 5:170-179 (2014).


Funding

Ultraestructura y citoquímica de la osmorregulación de la epidermis de los anfibios
CAICYT (1983-1986) Funding: 8.103.690 pesetas.
Entidades participantes: Universidad de Córdoba
PI: P Navas

Biología del crecimiento en animales y plantas superiores
DGICYT. PB86-0666-C02-02. (1987-1989) 6.600.000 pesetas
PI: P Navas

Desarrollo de un nuevo cultivo rico en proteinas
CICYT nº AGR89-0552 (1990-1992) 22.475.000 pesetas
PI: A Martín-Muñoz

Análisis experimental del crecimiento celular en plantas y animales superiores
DGICYT nº PB89-0337-C02-01 (1990-1992) 6.600.000 pesetas
PI: P Navas

Factors regulating growth and differentiation of plant cells
Bridge Programme: Regeneration. CEE (1991-1993) 23.000.000 pesetas
PI: Jean Guern

Caracterización del sistema redox de la membrana plasmática de la célula eucariótica
DGICYT: PB92-0714 (1993-1995) 13.000.000 pesetas
PI: P Navas

La cadena redox de la membrana plasmática y su relación con el crecimiento
DGICYT HA93-064 (1994) 1.600.000 pesetas
PI: P Navas, M Böttger

Sistema redox de la membrana plasmática de células eucarióticas: Reconstitución, función antioxidante y regulación.
DGICYT: PB95-0560 (1996-1999) 24.000.000 pesetas
PI: P Navas

CoQ analogs in the control of cancer cells
Institute for Biomedical Research. The University of Texas at Austin (1997) 250.000 $
PI: P Navas

Desarrollo de productos lácteos con grasa monoinsaturada y suplementada con el antioxidante coenzima Q10’ con la finalidad de mejorar el proceso de envejecimiento celular participación de las membranas extramitocondrial.
Plan Nacional de I+D. 1FD97-0457-C02-02 (1999-2001) 26.500.000 pesetas
PI: P Navas

Cambios inducidos por el estrés oxidativo en la síntesis y distribución de Coenzima Q en levadura.
DGICYT. Fulbright 99014 (1999-2001) 3.200.000 pesetas
PI: P Navas

Protección por el CoQ frente al estrés oxidativo: su síntesis, distribución y regulación en células eucariotas.
DGICYT: PB98-0329 (1999-2002) 32.000.000 pesetas
PI. P Navas

Fisiología y bioquímica del crecimiento celular
Plan Andaluz de Investigación (J.A.) CVI 0177 (permanent funding program since 1989)
PI: P Navas

Regulación de la biosíntesis del coenzima Q en eucariontes
BMC2002-01602 (2003-2005) 168.000 €
PI: P Navas

Desarrollo de herramientas moleculares para el diagnóstico de enfermedades mitocondriales
Plan Nacional de I+D+I (PETRI) (2003-2004) 55,985 €
PI: P Navas

Genetics of coenzyme Q deficiency in humans (UBIGENES)
EU 6FP contract 005151 (LSHB-CT-2004) (2005-2007) 1.600.000 €
PI: P Navas

Genética y fisiopatología de la deficiencia de CoQ en humanos
FIS (PI041617) (2005-2007) 111.550 €
PI: J.A. Sánchez

Influencia de una alimentación mediterránea suplementada en coenzima Q sobre el estrés oxidativo y la disfunción endotelial del envejecimiento
SAS AGL2004-07907/ALI (2005-2007) 100.000 €
PI: J.L: Miranda
Regulación transcripcional y post-traduccional de la biosíntesis del coenzima Q en organismos eucarióticos.
BFU2005-03017 (2006-2008) 190.400 €
PI: P Navas

Restricción calórica y rendimiento deportivo
DEP2005-00238-C04-04 (2006-2008) 37.723 €
PI: G López-Lluch

Envejecimiento saludable: mecanismos loleculares de regulación de la homeostasis redox en la restricción calórica
JA CVI 648 (2006-2008) 110.080 €
PI: P Navas

Alterations in membrane composition and function with caloric restriction
National Institute of Health (NIH) (1 R01 AG028125-01) (2007-2012) 250.000 $ (CABD)
PI: JJJ Ramsey, P Navas

Nuclear genes mutations in human primary coenzyme Q deficiency
National Institute of Health (NIH) (1R01HD057543-01) (2008-2013) 200.000 $ (CABD)
PI: M Hirano, P Navas

Genes nucleares en la deficiencia de coenzima Q humana
Plan Andaluz de I+D+I PI08-CTS-3988 (2009-2013) 288.000 €
PI: P Navas

Causas moleculares del sindrome de la deficiencia de Coenzima Q
ISCIII-FIS: PI080500 (2009-2011) 475.000 €
PI: P Navas

Investigación y desarrollo de nuevas posibilidades de aplicaciones terapéuticas en el aceite de oliva.
Ministerio de Ciencia e Innovación: IPT-060000-2010-028 (2010-2013) 682.890 €
Subcontract CABD 198.890 €
Coordinated by M Martín
PI: P Navas (CABD)

Caracterización fenotípica y molecular del síndrome de la deficiencia de coenzima Q
ISCIII-FIS: PI11/00078 (2012-2014) 276.320 €
PI: P Navas

Coenzyme Q10 deficiency syndrome: understanding the genotype-phenotype association and metabolic dysfunction through generation of induced pluripotent stem cells (ipscs) from patient-specific uncorrected and genetically-corrected cells.
ERANET-RARE  2012 (2013-2015) 150.000 €
PI: P Menéndez

Utilización de células madre pluripotentes inducidas (iPS) para el estudio y tratamiento de enfermedades mitocondriales
CIBERER ACCI 2012 (2013) 65.000 €
PI: R Garesse

Terapia del síndrome de deficiencia de CoQ10 
Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía.
(CTS943) (2014-2018) 221.000 €
PI: Plácido Navas